The Late Cretaceous (100.5–66 Ma) is the more recent of two epochs into which the Cretaceous Period is divided in the geologic time scale. Rock strata from this epoch form the Upper Cretaceous Series. The Cretaceous is named after creta, the Latin word for the white limestone known as chalk. The chalk of northern France and the white cliffs of south-eastern England date from the Cretaceous Period.

During the Late Cretaceous, the climate was warmer than present, although throughout the period a cooling trend is evident. The tropics became restricted to equatorial regions and northern latitudes experienced markedly more seasonal climatic conditions.

Due to plate tectonics, the Americas were gradually moving westward, causing the Atlantic Ocean to expand. The Western Interior Seaway divided North America into eastern and western halves; Appalachia and Laramidia. India maintained a northward course towards Asia. In the Southern Hemisphere, Australia and Antarctica seem to have remained connected and began to drift away from Africa and South America. Europe was an island chain. Populating some of these islands were endemic dwarf dinosaur species.

In the Late Cretaceous, the hadrosaurs, ankylosaurs, and ceratopsians experienced success in Asiamerica (Western North America and eastern Asia). Tyrannosaurs dominated the large predator niche in North America. They were also present in Asia, although were usually smaller and more primitive than the North American varieties. Pachycephalosaurs were also present in both North America and Asia. Dromaeosaurids shared the same geographical distribution, and are well documented in both Mongolia and Western North America. Additionally therizinosaurs (known previously as segnosaurs) appear to have been in North America and Asia. Gondwana held a very different dinosaurian fauna, with most predators being abelisaurids and carcharodontosaurids; and titanosaurs being among the dominant herbivores. Spinosaurids were also present during this time.

Birds became increasingly common, diversifying in a variety of enantiornithe and ornithurine forms. Early Neornithes such as Vegavis co-existed with forms as bizarre as Yungavolucris and Avisaurus. Though mostly small, marine Hesperornithes became relatively large and flightless, adapted to life in the open sea.

Though primarily represented by azhdarchids, other forms like pteranodontids, tapejarids (Caiuajara and Bakonydraco), nyctosaurids and uncertain forms (Piksi, Navajodactylus) are also present. Historically, it has been assumed that pterosaurs were in decline due to competition with birds, but it appears that neither group overlapped significantly ecologically, nor is it particularly evident that a true systematic decline was ever in place, especially with the discovery of smaller pterosaur species.

Several old mammal groups began to disappear, with the last eutriconodonts occurring in the Campanian of North America. In the northern hemisphere, cimolodont, multituberculates, metatherians and eutherians were the dominant mammals, with the former two groups being the most common mammals in North America. In the southern hemisphere there was instead a more complex fauna of dryolestoids, gondwanatheres and other multituberculates and basal eutherians; monotremes were presumably present, as was the last of the haramiyidans, Avashishta.

Mammals, though generally small, ranged into a variety of ecological niches, from carnivores (Deltatheroida), to mollusc-eater (Stagodontidae), to herbivores (multituberculates, Schowalteria, Zhelestidae and Mesungulatidae) to highly atypical cursorial forms (Zalambdalestidae, Brandoniidae).^{[citation needed]}