The Middle East and North Africa (MENA), also referred to as West Asia and North Africa (WANA) or South West Asia and North Africa (SWANA), is a geographic region which comprises the Middle East (also called West Asia) and North Africa together. It exists as an alternative to the concept of the Greater Middle East, which comprises the bulk of the Muslim world. The region has no standardized definition and groupings may vary, but the term typically includes countries like Algeria, Bahrain, Egypt, Iraq, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, Palestine, Qatar, Saudi Arabia, Syria, Tunisia, the United Arab Emirates, and Yemen.

As a regional identifier, the term "MENA" is often used in academia, military planning, disaster relief, media planning (as a broadcast region), and business writing. Moreover, it shares a number of cultural, economic, and environmental similarities across the countries that it spans; for example, some of the most extreme impacts of climate change will be felt in MENA.

Some related terms have a wider definition than MENA, such as MENASA (lit. 'Middle East and North Africa and South Asia') or MENAP (lit. 'Middle East and North Africa and Afghanistan and Pakistan'). The term MENAT explicitly includes Turkey, which is usually excluded from some MENA definitions, even though Turkey is almost always considered part of the Middle East proper. Ultimately, MENA can be considered as a grouping scheme that brings together most of the Arab League and variously includes their neighbors, like Iran, Turkey, Israel, Cyprus, the Caucasian countries, Afghanistan, Pakistan, Malta, and a few others.

The Middle East and North Africa has no standardized definition; different organizations define the region as consisting of different territories, or do not define it as a region at all.

There is no MENA region amongst the United Nations Regional Groups, nor in the United Nations geoscheme used by the UNSD (though the latter does feature two subregions called 'Western Asia' and 'Northern Africa', see WANA). Some agencies and programmes of the United Nations do define the MENA region, but their definitions may contradict each other, and sometimes only apply to specific studies or reports.

Historians Michael Dumper and Bruce Stanley stated in 2007: 'For the purposes of this volume, the editors have generally chosen to define the MENA region as stretching from Morocco to Iran and from Turkey to the Horn of Africa. This definition thus includes the twenty-two countries of the Arab League (including the Palestinian Authority enclaves in the West Bank and Gaza Strip), Turkey, Israel, Iran, and Cyprus.' They stressed, however, how controversial and problematic this definition is, and that other choices could also have been made according to various criteria.

For its December 2012 global religion survey, the Pew Research Center grouped 20 countries and territories as 'the Middle East and North Africa', namely: 'Algeria, Bahrain, Egypt, Iraq, Israel, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, the Palestinian territories, Qatar, Saudi Arabia, Sudan, Syria, Tunisia, United Arab Emirates, Western Sahara and Yemen.'

For the Global Peace Index 2020, the Institute for Economics & Peace defined the MENA region as containing 20 countries: Algeria, Bahrain, Egypt, Iraq, Iran, Israel, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, Palestine, Qatar, Saudi Arabia, Sudan, Syria, Tunisia, United Arab Emirates, and Yemen.