The Danny Thomas Show (titled Make Room for Daddy for its first three seasons) is an American sitcom that ran from 1953 to 1957 on ABC and from 1957 to 1964 on CBS. Starring Danny Thomas as a successful night club entertainer, the show focused on his relationship with his family, yet went through a number of significant changes in cast and characters during the course of its run. Episodes regularly featured music by Thomas, guest stars and occasionally other cast members as part of the plot.

In March 1953, Thomas first signed the contract for the show with ABC and chose Desilu Studios to film it using its three-camera method. Two proposed titles during pre-production were The Children's Hour and Here Comes Daddy.

Thomas played the role of Danny Williams, a successful comedian and nightclub entertainer at the Copa Club, based on the iconic New York City nightclub the Copacabana. In the show's first iteration as Make Room for Daddy, Jean Hagen played Thomas' serious and loving wife Margaret. Their daughter Terry was played by Sherry Jackson and their son Rusty by Rusty Hamer. The show's premise involved Danny rarely having time to spend with his family and Margaret having to deal with the children virtually on her own. She often felt neglected by Danny, and on several occasions felt like leaving him. Margaret was a society woman and strict with the children, but loved her family.

Louise Beavers made several appearances during this era as the Williams' maid, Louise Evans, and often was at odds with Danny and sided with Margaret in most of the couple's arguments. Nana Bryant often appeared as Margaret's kind mother Julia, of whom Danny and the children were fond, but Margaret, who had been raised by her aunt and uncle because of her mother often being away on stage tours, was not as warm to her mother. (Bryant died in late 1955, and rather than the character being recast, she simply disappeared. When Louise Beavers became ill in 1955, Amanda Randolph assumed the role of Louise.)

The supporting cast included:

Hans Conried had nineteen guest appearances as Danny's eccentric Lebanese "Uncle Tonoose". Other frequent guests included Bill Dana as José Jiménez, Annette Funicello as an Italian exchange student named Gina Manelli, and Thomas' protégée Italian teenaged singer Piccola Pupa. Other notable guest stars included band leader and musician Harry James, who appeared in the episode "The Trumpet Player", child pianist Ginny Tiu playing Li Chow in "The Chinese Doll" and Jimmy Durante, who appeared as himself in the episode "Danny and Durante". Lucille Ball and Desi Arnaz appeared in one episode together as their characters from I Love Lucy, and appearing as themselves in various episodes were Bob Hope, Jack Benny, Milton Berle, Max Baer, Sammy Davis Jr., Dinah Shore, and Dean Martin. Tony Bennett made his television acting debut in 1959 as Danny's singing cousin Stephen from Toledo, and Paul Anka played a young up-and-coming singer, as did Bobby Rydell. Zsa Zsa Gabor played a nightclub performer. Tennessee Ernie Ford portrayed a singer named Kentucky Cal. Brenda Lee plays Danny's maid, whom he hires as a singer. Danny Thomas's real-life daughter Marlo Thomas guest starred in the episode "Everything Happens to Me".

For its first three years the show was titled Make Room for Daddy (retitled The Danny Thomas Show starting with season four) and garnered decent ratings, but failed to make the list of the top 30 programs. Shortly after the third season finished filming, Jean Hagen left the show over dissatisfaction with her role and frequent clashes with Danny Thomas. Thomas was upset with her for leaving, and felt the show would not last without her. However, he decided to push on. At the start of the fourth season, both Thomas and producer Sheldon Leonard were faced with a serious dilemma—how to explain Hagen's absence. To have "Danny" and "Margaret" divorce in that era would have been unacceptable to television audiences, so it was explained that Margaret had died suddenly off-screen. It was a risky move because until this time, no character on a TV situation comedy had died.

Danny was now a widower juggling a performing career while raising two children on his own. With the absence of Jean Hagen, character actress-comedienne Mary Wickes (who had worked with Thomas and singer-actress Doris Day in the 1952 Warner Bros. musical film I'll See You in My Dreams) was cast in the recurring role of Liz O'Neill, Danny Williams's no-nonsense press agent. Wickes remained with the show until 1958. During the show's fourth season, it was Liz, along with Louise and Danny's friends, who often looked after the children while he was touring. He decided to move them to a boarding school, but later relented and the family moved into a new apartment. Also in that year, Danny dated a few other women and nearly got engaged to a widowed singer until he found out she did not like children. By season's end, the ratings had suffered and it was decided that a wife and mother was needed to complete the family unit.