The Mali Empire (Manding: Mandé or Manden Duguba; Arabic: مالي, romanized: Mālī) was an empire in West Africa from c. 1226 to 1610. The empire was founded by Sundiata Keita (c. 1214 – c. 1255) and became renowned for the wealth of its rulers, especially Mansa Musa (Musa Keita). At its peak, Mali was the largest empire in West Africa, widely influencing the culture of the region through the spread of its language, laws, and customs.

The empire began as a small Mandinka kingdom at the upper reaches of the Niger River, centered around the Manding region. It began to develop during the 11th and 12th centuries as the Ghana Empire, or Wagadu, declined and trade epicentres shifted southward. The history of the Mali Empire before the 13th century is unclear, as there are conflicting and imprecise accounts by both Arab chroniclers and oral traditionalists. The first ruler for which there is accurate written information is Sundiata Keita, a warrior-prince of the Keita dynasty who was called upon to free the local people from the rule of the king of the Sosso Empire, Soumaoro Kanté. The conquest of Sosso in c. 1235 marked the emergence of Mali as a major power, with the Kouroukan Fouga as its constitution.

Following the death of Sundiata Keita, in c. 1255, the kings of Mali were referred to by the title mansa. In 1285 Sakura, a former slave of the imperial family who had risen to the rank of general, carried out a military coup. After his death, the lineage of the Keita dynasty was restored with the accession of Mansa Gao (c. 1300–1305). Mansa Musa took the throne in c. 1312. He made a famous pilgrimage to Mecca from 1324 to 1326, where his generous gifts and his expenditure of gold caused significant inflation in Egypt. Maghan I succeeded him as mansa c. 1337, but was deposed by his uncle Suleyman in 1341. It was during Suleyman's 19-year reign that Ibn Battuta visited Mali. Suleyman's death marked the end of Mali's Golden Age and the beginning of a slow decline.

The Tarikh al-Sudan records that Mali was still a sizeable state in the 15th century. At that time, the Venetian explorer Alvise Cadamosto and Portuguese traders confirmed that the peoples who settled within Gambia River were still subject to the mansa of Mali. Upon Leo Africanus's visit at the beginning of the 16th century, his descriptions of the territorial domains of Mali showed that it was still a kingdom of considerable size. However, from 1507 onwards neighboring states such as Diarra, Great Fulo, Yatenga, and the Songhai Empire chipped away at Mali's borders. In 1542, the Songhai invaded the capital but were unsuccessful in conquering the empire. Mali made a brief comeback in the late 16th century and was poised to take advantage of Songhai's collapse after the 1593 Moroccan invasion, but a disastrous defeat outside Djenne in 1599 ended those hopes. After that, the empire rapidly disintegrated, being replaced by independent chiefdoms. The Keitas retreated to the town of Kangaba, where they became provincial chiefs.

Much of the recorded information about the Mali Empire comes from 14th century Tunisian historian Ibn Khaldun, 14th century Moroccan traveller Ibn Battuta and 16th century Andalusian traveller Leo Africanus. The other major source of information comes from Mandinka oral tradition, as recorded by storytellers known as griots. Imperial Mali is also known through the account of Shihab al-'Umari, written in about 1340 by a geographer-administrator in Mamluk Egypt. His information about the empire came from visiting Malians taking the hajj, or pilgrim's voyage to Mecca. He had first-hand information from several sources, and from a second-hand source he learned of the visit of Mansa Musa. The traveller Ibn Battuta, who visited Mali in 1352 left the first account of a West African kingdom made directly by an eyewitness; the others are usually second-hand. The third great account is that of Ibn Khaldun, who wrote in the early 15th century. While the accounts are of limited length, they provide a fairly good picture of the empire at its height.

After Ibn Khaldun's death in 1406, there are no further Arab primary sources except for Leo Africanus, who wrote more than a century later. Arab interest in the Mali Empire declined after the Songhai conquered the northern regions of the empire which formed the primary contact between Mali and the Arab world. For the later period of the Mali Empire, the major written primary sources are Portuguese accounts of the coastal provinces of Mali and neighboring societies.

Mali, Mandé, Manden,Mande-Bissa and Manding are all various pronunciations of the same word across different languages and dialects. The version recorded by medieval Arab geographers is Mali (Arabic: مالي, romanized: Mālī). Mali is the Fula form of the word. In the Manding languages, the modern descendants of the language spoken at the core of the Mali Empire, Manden or Manding is the name of the region corresponding to the heartland of the Mali Empire.

Medieval sources are divided over whether Mali is the name of a town or a region. Ibn Battuta who visited the capital city from 1352 to 1353, called it Mali. The 1375 Catalan Atlas portrayed a "city of Melly" (Catalan: ciutat de Melly) in West Africa. Leo Africanus said that the capital city was called Melli. However, Ibn Fadlallah al-Umari gives Mali as the name of the capital province and Ibn Khaldun refers to Mali as a people, with each giving different names for the capital city itself. Whether Mali originated as the name of a town or region, the name was subsequently applied to the entire empire ruled from Mali.