Melitopol is a city and municipality in Zaporizhzhia Oblast, southeastern Ukraine. It is situated on the Molochna River, which flows through the eastern edge of the city into the Molochnyi Lyman estuary. Melitopol is the second-largest city in the oblast after Zaporizhzhia and serves as the administrative centre of Melitopol Raion. As of January 2022, Melitopol's population was estimated to be 148,851.

Melitopol has been under Russian control since March 2022. On 30 September 2022, the city was formally annexed by the Russian Federation; however, it remains internationally recognized as sovereign territory of Ukraine.

The city is located at the crossing of two major European highways: E58 Vienna – Uzhhorod – Kyiv – Rostov-on-Don and E105 Kirkenes – St. Petersburg – Moscow – Kyiv – Yalta. An electrified railway line of international importance goes through Melitopol. The city was once known as "the gateway to the Crimea"; prior to the 2014 Russian annexation of Crimea 80% of passenger trains heading to the peninsula passed through it and during the summer, road traffic reached 45,000 vehicles per day.

Both Ukrainian and Russian names are based on the Greek name Μελιτόπολις, lit. 'honey city'.

The city was called Kyz-Yar (Crimean Tatar: Qız Yar; Ukrainian: Киз-Яр), and Novooleksandrivka (Ukrainian: Новоолександрівка) before 1815 and 1842 respectively. It was renamed to the current name after on. In addition, the traditional Ukrainian names Melitopil (Мелітопіль) and Melytopil (Мелитопіль) were also used but no longer after the Ukrainian language was oppressed by the Soviet authorities.

In July 1769, Russian military commanders built a redoubt there, and Zaporizhia Cossacks carried out their duty service there. On 2 February 1784, Catherine II issued the decree to create the Taurida Oblast on the lands that had been won. The deputy of Novorossiya Grigory Potemkin signed the relation to establish a town that very year – and Cossacks' families and those of retired soldiers of Suvorov settled on the right bank of the Molochna River. Among others, Germans were encouraged to settle in the new province, and some villages in this area were for many years German-speaking, such as Heidelberg (now Pryshyb) some 50 km (31 mi) to the north of Melitopol.

In 1816, the settlement got the name sloboda of Novoalexandrovka. Its population was increasing due to the importation of peasants from the northern provinces of Ukraine and Russia. On 7 January 1842, the sloboda was recognized as a town and received the new name of Melitopol after a port city of Melita (from Greek Μέλι (meli) – "honey") which had been situated on the mouth of the Molochna River. At the end of the 19th century, the "Honey-city" had been developed as a trade center – there were some banks, credit organizations and wholesale stores. The largest enterprises in the city at the time were the iron foundry and the Brothers Klassen's machinery construction factory (1886), the railroad depot and the workshops.

Further development of the city was closely connected with trade, iron and engineering industries, and railway service in the Crimean direction. In the early twentieth century there were fifteen thousand people living in Melitopol. 30 factories and 350 shops operated in the city at that time. In the second half of the twentieth century there was a strong economic growth of the city: new factories, plants, and housing estates were constructed. Sixteen Melitopol business enterprises received All-Soviet Union significance status. Industrial products were exported to more than 50 countries.