Bissell joined LBNL, embarking on a career that would span decades and revolutionize our understanding of cancer biology. This marked the beginning of her impactful contributions to the field.

She challenged the prevailing view of cancer as solely a genetic disease and demonstrated the critical role of the microenvironment, specifically the extracellular matrix (ECM), in regulating cell behavior and differentiation. Her work established the ECM as a key player in normal tissue function and cancer development.

Bissell pioneered the use of 3D cell culture models to better mimic the tumor microenvironment, leading to more relevant and insightful research findings. Her work with 3D cultures changed the landscape of cancer research allowing researchers to study cell behaviour in environments that mimicked those of the body more closely.

Bissell held the position of Director of the Cell & Molecular Biology Division at LBNL, showcasing her leadership and expertise in shaping the direction of research within the laboratory. Her time as director helped to establish new research areas within LBNL and ensure that it remained at the forefront of cancer research.

She served as Director of the Life Sciences Division. As a director Bissell played a key role in defining LBNL's research strategy and ensured that it focused on the most impactful areas of cancer research.

Continues her research as a Distinguished Scientist at LBNL, actively involved in research and mentorship, solidifying her enduring legacy in the scientific community.