This paper showcased the importance of the microenvironment on cancer cell behavior. This paper described the effects of culturing cells in varying dextran concentration and discovered changes in the tumourigenicity of cells in different environments.

This review article summarized the current knowledge of the role of ECM in mammary gland development and cancer. Bissell's work elucidated the reciprocal relationship between ECM, gene expression, and cell behavior.

This paper demonstrated the differences between 2D and 3D cell cultures, providing key insights into cell behavior in the context of their environment. It made the case that 3D cultures better mimicked the "in vivo" environment.

This paper was written in response to a paper from Hanahan and Weinberg, who had first defined the hallmarks of cancer. Bissell and co-authors add context and location as important variables in defining cancer hallmarks.

This comprehensive review chronicled important discoveries that have shaped our understanding of breast cancer. This paper looked at the importance of cell context in mammary development and cancer.