Bissell's work has reshaped our understanding of cancer as a disease influenced by both genetic and environmental factors. Her discoveries have emphasized the dynamic interplay between cells and their microenvironment in promoting or suppressing cancer development.

Her research has provided a foundation for the development of novel cancer therapies targeting the tumor microenvironment. This includes approaches to modulate the ECM, signaling molecules, and cell-cell interactions within the tumor.

Bissell's research has contributed to the concept of personalized medicine, emphasizing the importance of considering individual differences in the tumor microenvironment when designing treatment strategies. Her work has highlighted the need to target unique characteristics of each tumor and its environment.