Bissell's research demonstrated that the malignant phenotype is not always irreversible, challenging the dogma that cancer cells are irreversibly committed to their cancerous state. Her work with breast cancer cells showed that by altering the ECM or introducing specific signals, it was possible to revert cancerous cells back to a more normal phenotype. This groundbreaking discovery laid the foundation for future research into targeted therapies.

She discovered that the ECM plays a critical role in regulating gene expression, impacting cell differentiation and behavior. This established the concept of 'dynamic reciprocity,' where cells and their microenvironment constantly interact to influence each other's behavior.

Her pioneering work with 3D cell culture models provided a more realistic representation of the tumor microenvironment, leading to improved and more clinically relevant cancer research. The 3D culture models demonstrated how the ECM, signaling molecules, and cell-cell interactions can influence cancer progression.

Bissell's research elucidated the role of myoepithelial cells in maintaining mammary gland structure and preventing cancer development. Myoepithelial cells were shown to act as tumor suppressors, influencing the behavior of epithelial cells and preventing them from becoming cancerous.

Continues to investigate the interplay between genetics, epigenetics, and the microenvironment in cancer development and progression. Her current work continues to shape understanding of cancer biology and identify new therapeutic targets. Her focus is on understanding how the ECM and microenvironment can alter gene expression and potentially reverse cancerous phenotypes.