Newport is a city in and the county seat of Cocke County, Tennessee, United States. As of the 2020 census, Newport had a population of 6,868. Newport is located along the Pigeon River.

The Great Indian Warpath passed through what is now Newport en route to the ancient Cherokee hunting grounds of northeastern Tennessee. The Warpath crossed the Pigeon River at a point approximately 0.2 miles (0.3 km) east of the McSween Memorial Bridge (US-321), in an area where the river is normally low enough to walk across. The first European traders to the area, arriving in the mid-18th century, called this point along the Pigeon River the "War Ford".

During the American Revolution, the Cherokee aligned themselves with the British, and launched sporadic attacks against early Euro-American settlers in the Holston valley. In the waning months of the conflict in 1782, a detachment led by Gen. Charles McDowell of North Carolina crossed the mountains into what is now Tennessee to join up with Col. John Sevier's local forces and initiate an aggressive campaign against the hostile Cherokee. In August of that year, Sevier crossed the Pigeon at War Ford, attacking and killing several Cherokee camped along the river's banks. This assault was one of the final engagements of the Revolution.

At the close of the Revolution, the first Euro-American settlers arrived in the Newport area, ensconcing themselves in the vicinity of the strategic river fords. Peter Fine established a ferry on the north bank of the French Broad in the early 1780s, and in 1783 John Gilliland settled opposite Fine's Ferry in what is now Oldtown. Shortly thereafter, Emanuel Sandusky, a Polish immigrant, established a farm on the land where the Cocke County Memorial Building now stands, and Samuel O'Dell settled at the junction of the Pigeon River and Cosby Creek. Sometime in the 1790s, the Gilliland family donated 50 acres (200,000 m²) of land for a town square and courthouse to be situated opposite Fine's Ferry on the banks of the French Broad, and the town of New Port was born.

For nearly a quarter-century, the residents of the Newport area lived under constant threat of attack from Cherokee crossing the mountains from North Carolina. Shortly after the arrival of the first Euro-American settlers, Peter Fine sought to quell this threat by leading a punitive expedition against the Cherokee town of Cowee in North Carolina, which Fine captured and burned. The Cherokee responded by stealing Fine's livestock and attempting to herd them back to North Carolina. Fine gave chase and managed to retrieve the livestock, but on the return march he was ambushed and his brother, Vinet, was killed. The Cherokee were in pursuit, and Vinet's body was hidden in a hole in a frozen creek for later retrieval. The creek melted and the body was lost. The creek was named Fines Creek. Shortly thereafter, two O'Dells were killed, one of Sandusky's daughters was kidnapped, and several others settlers were killed or scalped.

To provide defense against these sporadic attacks, the early settlers erected a series of forts in the area. Wood's Fort guarded the Forks-of-the-River just downstream from Newport, and McCoy's Fort and Whitson's Fort defended the area to the south. Other installations included Huff's Fort at what is now Del Rio. With Sevier's victory at the Battle of Boyds Creek and the ensuing Treaty of Dumplin in 1785, Cherokee influence in the area began to wane. In the 1790s, the Cherokee signed a series of treaties which essentially ceded most of the land on the Tennessee side of the Great Smokies to the U.S. government. By 1800, Cherokee attacks in the Newport area had been drastically reduced.

The French Broad River passes 1 mile (1.6 km) north of the current city limits. As the French Broad empties into the Tennessee River, towns along its banks are connected via waterway to New Orleans and the Gulf of Mexico. In the early 19th century, William Faubion, who lived just northeast of New Port, managed to reach New Orleans with a flatboat shipment and return safely. In early 19th-century East Tennessee, which was riddled with poor roads and hilly terrain, river travel was a relatively convenient mode of transportation. "New Port", situated on the French Broad near Forks-of-the-River, quickly developed into a flatboat trading hub.

William Garrett (1774–1853) arrived in New Port in the late 1790s and built a plantation, known as Beechwood Hall, just south of Fine's Ferry. Many early travelers, including several circuit riders and religious leaders, were entertained at Garrett's mansion. During the War of 1812, Garrett shipped eight large flatboats stocked with food and whiskey to the U.S. Navy in New Orleans.