Philosophy of mind is a branch of philosophy that deals with the nature of the mind and its relation to the body and the external world.

The mind–body problem is a paradigmatic issue in philosophy of mind, although a number of other issues are addressed, such as the hard problem of consciousness and the nature of particular mental states. Aspects of the mind that are studied include mental events, mental functions, mental properties, consciousness and its neural correlates, the ontology of the mind, the nature of cognition and of thought, and the relationship of the mind to the body.

Dualism and monism are the two central schools of thought on the mind–body problem, although nuanced views have arisen that do not fit one or the other category neatly.

Most modern philosophers of mind adopt either a reductive physicalist or non-reductive physicalist position, maintaining in their different ways that the mind is not something separate from the body. These approaches have been particularly influential in the sciences, especially in the fields of sociobiology, computer science (specifically, artificial intelligence), evolutionary psychology and the various neurosciences. Reductive physicalists assert that all mental states and properties will eventually be explained by scientific accounts of physiological processes and states. Non-reductive physicalists argue that although the mind is not a separate substance, mental properties supervene on physical properties, or that the predicates and vocabulary used in mental descriptions and explanations are indispensable, and cannot be reduced to the language and lower-level explanations of physical science. Continued neuroscientific progress has helped to clarify some of these issues; however, they are far from being resolved. Modern philosophers of mind continue to ask how the subjective qualities and the intentionality of mental states and properties can be explained in naturalistic terms.

The problems of physicalist theories of the mind have led some contemporary philosophers to assert that the traditional view of substance dualism should be defended. From this perspective, this theory is coherent, and problems such as "the interaction of mind and body" can be rationally resolved.

The mind–body problem concerns the explanation of the relationship that exists between minds, or mental processes, and bodily states or processes. The main aim of philosophers working in this area is to determine the nature of the mind and mental states/processes, and how—or even if—minds are affected by and can affect the body.

Perceptual experiences depend on stimuli that arrive at our various sensory organs from the external world, and these stimuli cause changes in our mental states, ultimately causing us to feel a sensation, which may be pleasant or unpleasant. For example, someone's desire for a slice of pizza will tend to cause that person to move his or her body in a specific manner and direction to obtain what he or she wants. The question, then, is how it can be possible for conscious experiences to arise out of a lump of gray matter endowed with nothing but electrochemical properties.

A related problem is how someone's propositional attitudes (e.g. beliefs and desires) cause that individual's neurons to fire and muscles to contract. These comprise some of the puzzles that have confronted epistemologists and philosophers of mind from the time of René Descartes.