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Olpasiran (development code AMG 890, formerly ARO-LPA[1]) is an investigational small interfering RNA (siRNA) therapy developed by Arrowhead Pharmaceuticals and licensed worldwide by Amgen. As of October 2025, it is in phase 3 trials to evaluate whether it reduces cardiovascular risk by lowering lipoprotein(a) (Lp(a)).[2] Olpasiran is under investigation to reduce major adverse cardiovascular events in patients with established atherosclerotic cardiovascular disease (ASCVD) and elevated Lp(a) concentrations, as well as for individuals at high-risk for a first cardiovascular event and elevated Lp(a) concentrations.[3]

Adverse effects

[edit]

In clinical trials, olpasiran was generally well tolerated. The most frequent adverse events were injection-site reactions,[4] which were usually mild.[5] No major safety signals emerged.[6]

Mechanism of action

[edit]

Olpasiran is a N-acetylgalactosamine (GalNAc)–conjugated siRNA.[5] After uptake by hepatocytes through the asialoglycoprotein receptor,[7] the antisense strand is incorporated into the RNA-induced silencing complex (RISC),[5] which inhibits expression of the LPA gene. This reduces apolipoprotein(a) production and lowers circulating Lp(a).[4]

Olpasiran is a double-stranded siRNA[7] chemically modified for stability and conjugated with GalNAc[2] to enable hepatocyte targeting.[7]

History

[edit]

Olpasiran was originally developed by Arrowhead Pharmaceuticals (as ARO-LPA) and licensed to Amgen in 2016.[8] In 2022, Arrowhead sold a portion of its royalty rights to Royalty Pharma.[9]

Research

[edit]

In a phase 1 trial, one dose of olpasiran led to lower Lp(a) levels sustained for up to 6 months.[4] The phase 2 OCEAN(a)-DOSE trial demonstrated dose-dependent, sustained Lp(a) lowering[2] with acceptable tolerability. In OCEAN(a)-DOSE, olpasiran reduced Lp(a) levels by more than 95% at some doses as compared to placebo,[4] with durable suppression persisting for up to 48 weeks after treatment discontinuation.[10] A large phase 3 cardiovascular outcomes trial began in 2022[11] to determine whether Lp(a) reduction with olpasiran decreases events in patients with established ASCVD and a history of cardiovascular events.[2][12]

References

[edit]
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Olpasiran

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Olpasiran is an investigational therapeutic developed by that targets elevated lipoprotein(a) [Lp(a)] levels in patients with established atherosclerotic cardiovascular disease, aiming to reduce the risk of . First entering around 2020, olpasiran has demonstrated significant Lp(a) reductions in , such as the OCEAN(a)-DOSE trial, where doses administered every 12 weeks achieved up to 95% lowering of Lp(a) concentrations with an acceptable safety profile. As of 2023, it is under evaluation in the ongoing OCEAN(a) Outcomes Trial (NCT05581303), a , , study assessing its impact on the of death, nonfatal myocardial infarction, or . Olpasiran works by targeting liver cells to inhibit the production of apolipoprotein(a), a key component of Lp(a), which is a genetically determined risk factor for cardiovascular disease independent of other lipid levels. In the Phase 2 OCEAN(a)-DOSE study involving 281 participants with elevated Lp(a) and cardiovascular disease, olpasiran not only reduced Lp(a) but also lowered oxidized phospholipids, though it did not significantly impact inflammatory markers. Early data suggest prolonged effects post-treatment, with sustained Lp(a) reductions of 40% to 50% observed for up to 60 weeks after the last dose in higher-dose cohorts. continues to advance olpasiran as a potential for Lp(a)-mediated cardiovascular risk, with no approved treatments currently available for this target.

Medical Uses

Indications

Olpasiran is an primarily indicated for the reduction of elevated lipoprotein(a) [Lp(a)] levels in adults with established atherosclerotic cardiovascular disease (ASCVD). This targeted approach aims to lower the risk of , including coronary heart disease death, myocardial infarction, and , in patients with persistently high Lp(a) despite standard . The investigational use is supported by the established association between genetically determined elevated Lp(a) levels and an increased risk of atherosclerotic cardiovascular events, such as and peripheral artery disease. Clinical development of olpasiran focuses exclusively on in individuals with documented ASCVD and Lp(a) concentrations ≥ 200 nmol/L, reflecting its role in addressing residual cardiovascular risk driven by Lp(a). There are no or approved indications for in individuals without established ASCVD, nor for other lipid disorders such as elevated remnant cholesterol. This specificity underscores olpasiran's development as a for Lp(a)-mediated cardiovascular risk rather than broad lipid management.

Dosage and Administration

Olpasiran is administered via , typically self-administered by patients or performed by a healthcare provider in a clinical setting. In , such as the OCEAN(a)-DOSE study, dosing regimens ranged from 10 mg to 225 mg, administered either quarterly or every 12 weeks, with the 75 mg dose every 12 weeks demonstrating the most robust lipoprotein(a) reduction of over 95%. Lower dose of 10 mg was explored in a quarterly schedule (every 12 weeks) to assess . For patients with elevated lipoprotein(a) levels and atherosclerotic cardiovascular disease, treatment is initiated with the first according to the dosing schedule, followed by maintenance injections, with schedules tailored based on to optimize and . The investigational regimen from emphasizes quarterly or bi-annual administration to maintain sustained reductions in lipoprotein(a) levels, avoiding more frequent dosing to minimize injection burden. Monitoring of lipoprotein(a) levels is essential post-initiation, with assessments recommended at baseline, after the first dose, and periodically thereafter to evaluate therapeutic response and guide any adjustments in dosing frequency. These approaches are derived from ongoing Phase 3 evaluations like the PreEvent trial, which continue to refine administration protocols for broader clinical application.

Pharmacology

Mechanism of Action

Olpasiran is a () designed to target and silence the expression of apolipoprotein(a) [apo(a)] in . As an siRNA therapeutic, olpasiran incorporates chemical modifications for enhanced stability and incorporates a ligand that facilitates uptake by liver cells via the , enabling it to bind specifically to the LPA gene transcript and trigger its degradation through the (). This process inhibits the hepatic synthesis of apo(a), a that assembles with low-density lipoprotein (LDL) to form lipoprotein(a) [Lp(a)], thereby reducing circulating Lp(a) levels. Elevated Lp(a) levels are largely genetically determined, with variations in the LPA gene contributing to a causal role in atherosclerotic cardiovascular disease (ASCVD) by promoting atherosclerosis through oxidized phospholipid accumulation and enhancing thrombosis via kringle domains that mimic plasminogen. Olpasiran's mechanism specifically addresses this genetic predisposition by primarily lowering Lp(a), with modest reductions observed in other lipid parameters such as LDL cholesterol (approximately 22-25% placebo-adjusted reduction in Phase 2 trials) and apolipoprotein B, but without significant impact on remnant cholesterol, distinguishing it from broader lipid-lowering therapies like statins. In clinical studies, this targeted reduction has demonstrated dose-dependent decreases in Lp(a) of up to 97% at higher doses.

Pharmacokinetics

Olpasiran, a -conjugated , is administered via and demonstrates rapid absorption, with maximum observed plasma concentrations (Cmax) typically achieved within 3 to 8 hours post-dose. This quick absorption profile is consistent across dose levels evaluated in early clinical studies. Following absorption, olpasiran is primarily distributed to the due to its conjugation with , which facilitates targeted uptake by via the . Once in the liver, the drug exhibits prolonged residence, with estimates in humans ranging from approximately 27 to 42 days based on kinetic-pharmacodynamic modeling. Olpasiran is slowly degraded by within hepatocytes, contributing to its metabolic stability and extended duration of action. The is shorter, ranging from 3 to 8 hours, with the majority of the drug cleared from within 2 to 3 days. A dedicated study has evaluated the of olpasiran in participants with varying degrees of to assess potential impacts on . No significant have been observed with , allowing for concurrent use in where a substantial proportion of participants were on stable statin therapy. This lack of interaction supports olpasiran's compatibility with standard . The overall , characterized by rapid but sustained hepatic effects, enables infrequent dosing intervals of up to 3 to 6 months while maintaining therapeutic lipoprotein(a) reduction.

Clinical Development

Preclinical Studies

of olpasiran, a targeting the LPA gene, began with to evaluate its mechanism and potential safety profile. In , olpasiran demonstrated potent inhibition of LPA mRNA translation, which is essential for reducing apolipoprotein(a) synthesis without affecting off-target . Exploratory using and serum further confirmed no activation of , , or , indicating low risk at therapeutic concentrations. These findings established the via as a key feature for efficacy and safety. Animal studies progressed to and to assess and dose-response effects. In expressing human LPA, a single of 1 mg/kg olpasiran resulted in greater than 80% reduction in serum Lp(a) levels, sustained for up to 36 days. Similarly, in , doses ranging from 2 to 10 mg/kg achieved Lp(a) reductions exceeding 80%, with effects lasting 5-8 weeks post-administration, and up to 90% or more in without impacts on other lipid parameters like LDL-C or . These models confirmed olpasiran's specificity for Lp(a) lowering, supporting its advancement to . Toxicology evaluations in Sprague Dawley rats and revealed no significant adverse effects at therapeutic doses. In repeated-dose studies up to 150 mg/kg monthly for 6-9 months, olpasiran was well tolerated at the highest dose tested, with only minimal, reversible changes such as transient elevations in (e.g., ) and mild hepatocellular vacuolation observed, deemed non-adverse and consistent with effects rather than . No evidence of or off-target toxicity on other organs was noted, with all olpasiran-related alterations fully reversing post-treatment except for minor platform-specific findings. These results provided a strong safety foundation for .

Phase 2 Trials

The clinical development of olpasiran focused on evaluating its efficacy, safety, and tolerability in reducing lipoprotein(a) [Lp(a)] levels among patients with established atherosclerotic cardiovascular disease (ASCVD). The primary trial in this stage was the OCEAN(a)-DOSE study, a that enrolled 281 adults with ASCVD and elevated Lp(a) levels (≥150 nmol/L or ≥60 mg/dL). Participants were randomized to receive olpasiran at one of the following doses: 10 mg every 12 weeks, 75 mg every 12 weeks, 225 mg every 12 weeks, or 225 mg every 24 weeks, or matching for 48 weeks, with the being the placebo-adjusted percentage change in Lp(a) concentration from baseline to week 36. Olpasiran demonstrated a reduction in Lp(a) levels, with higher doses achieving profound and sustained lowering. For instance, the 75 mg every 12 weeks dose resulted in a 97.4% placebo-adjusted mean reduction in Lp(a) from baseline at week 36, the 225 mg every 12 weeks dose in 101.1%, and the 225 mg every 24 weeks dose in 100.5%. The was evident across the tested regimens, with olpasiran doses ranging from 10 mg to 225 mg showing proportional Lp(a) reductions, and no observed at the highest doses evaluated. Notably, the effects persisted after treatment discontinuation, with participants on doses ≥75 mg every 12 weeks maintaining approximately 40% to 50% Lp(a) reduction during the off-treatment follow-up period. Safety data from the OCEAN(a)-DOSE trial indicated that olpasiran was generally well-tolerated, with primarily consisting of mild injection-site reactions. No serious adverse events were attributed to Lp(a) lowering, and the overall incidence of treatment-emergent adverse events was similar between olpasiran and groups, supporting the drug's favorable short-term safety profile in this population. These findings from the provided for olpasiran's Lp(a)-lowering potential and informed dosing strategies for subsequent evaluation.

Phase 3 Trials

Olpasiran is currently being evaluated in two : the OCEAN(a)-Outcomes Trial (NCT05581303) and the OCEAN(a)-PreEvent Trial (NCT07136012). The OCEAN(a)-Outcomes Trial is a , , , multicenter study designed to assess its impact on in patients with elevated lipoprotein(a) [Lp(a)] levels and established atherosclerotic cardiovascular disease (ASCVD). The trial involves of olpasiran every 12 weeks, with dosing informed by results showing effective Lp(a) reduction at similar intervals. The OCEAN(a)-Outcomes study enrolled 7,297 participants with high-risk ASCVD, specifically those with a history of myocardial infarction or plus at least one additional risk factor. Inclusion criteria require an Lp(a) level of ≥200 nmol/L during screening, targeting individuals aged 18 to 85 years at elevated risk for . The trial began on December 14, 2022, and is expected to complete in December 2026. The is the time to the first occurrence of coronary heart disease death, myocardial infarction, or , evaluated over approximately 4 years to determine if olpasiran reduces these compared to . As an event-driven trial, it aims to provide confirmatory evidence of olpasiran's efficacy in preventing in this population. The OCEAN(a)-PreEvent Trial (NCT07136012) is a , , , multicenter study assessing olpasiran's use to prevent first in participants with elevated Lp(a) but without established ASCVD. It plans to enroll approximately 11,000 participants aged 40 to 80 years with Lp(a) ≥150 nmol/L and additional cardiovascular risk factors. The trial began on August 22, 2025, with primary completion estimated for October 2031, and is currently recruiting as of January 2026. The primary endpoint is the time to the first occurrence of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or due to .

Safety and Side Effects

Adverse Reactions

In , the most common associated with olpasiran were injection-site reactions, including erythema and pain, occurring in approximately 19-24% of patients receiving higher doses (≥75 mg), compared to 11% in the group; these were generally mild, transient, and resolved within 48 hours without intervention. These reactions were more frequent at higher doses and led to discontinuation in a small number of cases (about 1-2%), often in patients with preexisting . Serious adverse events were rare and occurred at similar rates between olpasiran and groups, with no evidence of increased risk for bleeding or despite substantial Lp(a) lowering; for instance, or were reported in only 2% of olpasiran-treated patients versus 0% in placebo, and thrombocytopenia was infrequent (0-2% across groups). , primarily mild local cutaneous events, were observed in 6% of olpasiran patients compared to 2% in placebo, with no systemic or severe cases reported. Long-term monitoring in the OCEAN(a)-DOSE trial extension revealed no clinically significant effects on , as were infrequent (≤3%) and comparable to , with no elevations exceeding three times the . Overall, the safety profile was consistent across trial contexts, with rates similar to placebo (81-88%).

Contraindications and Precautions

As an , olpasiran has not yet received , and its and precautions are primarily informed by and safety considerations from ongoing . include known to olpasiran, therapeutics, or any of its components, as have been observed more frequently with olpasiran than placebo in . Pregnancy is also contraindicated due to the unknown effects on , with requiring to use during treatment and for at least 90 days after the last dose, and mandating reporting of any pregnancy exposures. Precautions are advised for patients with , as individuals with an below have been excluded from key trials. Caution is also recommended in patients with , where trial exclusions for aspartate aminotransferase or levels exceeding three times the , total over twice the upper limit of normal, or any history of highlight the need to monitor for potential off-target effects on . Additionally, precautions should be taken in those with a history of or , as such conditions have led to exclusions in cardiovascular outcome trials to mitigate bleeding risks in this patient population. Regarding , no significant interactions have been identified in to date, though caution is warranted when co-administering olpasiran with or commonly used in patients with atherosclerotic cardiovascular disease, given the exclusion of participants with and the need for careful monitoring in this context.

Development History

Discovery and Early Research

Olpasiran, also known as AMG 890 or ARO-LPA, was developed by in collaboration with Arrowhead Pharmaceuticals Inc. as a synthetic, double-stranded conjugated with to enable targeted delivery to in the . This platform leverages to inhibit the translation of from the LPA gene, which encodes apolipoprotein(a), a key component of lipoprotein(a) [Lp(a)]. The development was initiated through a worldwide exclusive license granted by Arrowhead to Amgen in September 2016 for the ARO-LPA program, building on Arrowhead's earlier research efforts. The scientific rationale for olpasiran stemmed from the unmet clinical need to address elevated Lp(a) levels, which are largely genetically determined and unresponsive to conventional therapies like statins. Genetic studies have established Lp(a) as a causal risk factor for atherosclerotic cardiovascular disease, with elevated levels associated with a log-linear increase in coronary artery disease risk starting at concentrations of 20-30 mg/dL and contributing significantly to myocardial infarction events in certain populations. This genetic basis, highlighted in large-scale Mendelian randomization analyses, underscored the potential for siRNA-based interventions to reduce Lp(a) production directly in the liver, where it is synthesized. Key early milestones included the filing of a foundational patent application by for LPA-targeted RNAi constructs (WO2017059223A2) on September 30, 2016, which laid the groundwork for olpasiran's molecular design. Development progressed to the first administration of olpasiran in a in July 2018, marking the transition from to human evaluation. Preclinical data, demonstrating dose-dependent reductions in Lp(a) levels of over 80% in and cynomolgus monkeys, were first detailed in a 2022 publication, with effects lasting 5-8 weeks after a single dose. These findings validated the 's liver-targeting efficacy and supported further advancement.

Regulatory Milestones

Olpasiran entered following the filing of an application with the around 2020, enabling the initiation of its (NCT04270760) in July 2020. In October 2020, the FDA granted to olpasiran for the treatment of elevated lipoprotein(a) in patients with atherosclerotic cardiovascular disease (ASCVD) to reduce the risk of . In , olpasiran received a positive opinion granting a waiver from a Paediatric Investigation Plan (PIP) from the in March 2021, supporting its development pathway. As of 2023, the drug's Phase 2 trial (EudraCT 2019-003688-23) was completed under EMA oversight, with ongoing evaluation. Olpasiran is not approved for use in any jurisdiction as of 2026 and remains . data from the ongoing OCEAN(a)-Outcomes trial (NCT05581303), expected in 2026, are anticipated to support a submission to the by 2026-2027.

Society and Culture

Commercial Aspects

Olpasiran is being developed by , a biotechnology company focused on innovative therapeutics for cardiovascular diseases, as part of its pipeline to address unmet needs in . Amgen holds global rights to the drug, with no major partnerships announced for its to date, allowing the company to retain full control over development and . The projected market for therapies targeting elevated lipoprotein(a) [Lp(a)] levels is forecasted to reach approximately $8-9 billion by 2033, driven by the high prevalence of elevated Lp(a) in approximately 20% of high-risk populations with atherosclerotic cardiovascular disease (ASCVD). This market potential underscores Amgen's strategic investment in olpasiran, positioning it as a key asset in the growing sector of RNA-based lipid-lowering agents. As an investigational , olpasiran is likely to carry a high cost upon potential approval, similar to other , with pricing strategies influenced by its and the value it provides in reducing cardiovascular risk. Coverage under programs like Medicare for patients with established ASCVD could facilitate broader access, though final pricing and reimbursement details remain pending regulatory outcomes.

Research Implications

Olpasiran represents a paradigm shift in the management of elevated lipoprotein(a) [Lp(a)] levels, as it is the first investigational small interfering RNA (siRNA) therapy specifically designed to target and substantially reduce Lp(a), a genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD). By achieving reductions of over 90% in Lp(a) concentrations in Phase 2 studies, olpasiran provides direct evidence that Lp(a) is a modifiable risk factor, supporting causal associations established through Mendelian randomization studies and potentially influencing future clinical guidelines for genetic hyperlipidemias. This targeted approach could redefine treatment strategies for patients with elevated Lp(a), particularly those with familial hypercholesterolemia or other inherited dyslipidemias, by addressing a long-unmet need in lipid-lowering therapies. Looking ahead, olpasiran's development highlights promising future directions, including potential with , which have been shown to independently reduce Lp(a) levels by approximately 15-30%. Such combinations may yield additive effects on Lp(a) lowering, as evidenced by studies where PCSK9 inhibition further decreased Lp(a) when added to other lipid-modifying agents, potentially enhancing overall cardiovascular risk reduction without overlapping mechanisms. Although research on interactions with remnant cholesterol remains limited, olpasiran's specificity for Lp(a) suggests minimal interference, paving the way for integrated multimodal approaches in high-risk populations. Despite these advances, significant gaps in knowledge persist, particularly regarding the therapy's efficacy and safety across diverse populations, where ethnic variability in Lp(a) levels and ASCVD risk may influence outcomes. Ongoing Phase 3 trials, such as the PreEvent study, aim to address these by evaluating major adverse cardiovascular event reduction in Lp(a)-elevated subgroups, with modeling suggesting potential ASCVD event reductions of up to 25% in such patients, though confirmatory data from varied demographics are essential. These trials will be crucial for filling evidence gaps and informing equitable application of Lp(a)-targeted therapies globally.

References

  1. https://www.amgen.com/newsroom/press-releases/2023/08/amgen-presents-late-breaking-phase-2-olpasiran-data-at-esc-2023
  2. https://www.nejm.org/doi/full/10.1056/NEJMoa2211023
  3. https://clinicaltrials.gov/study/NCT05581303
  4. https://clinicaltrials.gov/study/NCT04270760
  5. https://www.amgentrials.com/study/?id=20180109
  6. https://pubmed.ncbi.nlm.nih.gov/40846536/
  7. https://www.tctmd.com/news/olpasiran-cuts-lpa-not-inflammatory-markers-oceana-dose
  8. https://www.sciencedirect.com/science/article/pii/S073510972407671X
  9. https://www.insideprecisionmedicine.com/topics/precision-medicine/rna-inhibitor-olpasiran-dramatically-lowers-high-risk-cholesterol-in-cardiovascular-disease-patients/
  10. https://pmc.ncbi.nlm.nih.gov/articles/PMC12115060/
  11. https://www.acc.org/Latest-in-Cardiology/Articles/2022/11/01/22/00/sun-7pm-oceana-dose-aha-2022
  12. https://pmc.ncbi.nlm.nih.gov/articles/PMC11607505/
  13. https://cdn.clinicaltrials.gov/large-docs/20/NCT04987320/Prot_000.pdf
  14. https://www.sciencedirect.com/science/article/pii/S0149291822002399
  15. https://pmc.ncbi.nlm.nih.gov/articles/PMC9784597/
  16. https://cdn.clinicaltrials.gov/large-docs/60/NCT04270760/Prot_000.pdf
  17. https://clinicaltrials.gov/study/NCT05489614
  18. https://pubmed.ncbi.nlm.nih.gov/35027752/
  19. https://europepmc.org/article/med/35027752
  20. https://www.jacc.org/doi/10.1016/j.jacc.2024.05.058
  21. https://www.amgentrials.com/study/?id=20180244
  22. https://consultqd.clevelandclinic.org/lipoproteina-progress-on-one-of-the-last-untreatable-frontiers-of-cardiovascular-risk
  23. https://clinicaltrials.gov/study/NCT07136012
  24. https://www.sciencedirect.com/science/article/pii/S0002870322000862
  25. https://ir.arrowheadpharma.com/node/16876/html
  26. https://pmc.ncbi.nlm.nih.gov/articles/PMC6620428/
  27. https://jamanetwork.com/journals/jama/fullarticle/184063
  28. https://patents.google.com/patent/WO2017059223A2/en
  29. https://www.amgentrials.com/study/?id=20170544
  30. https://www.amgen.com/newsroom/press-releases/2020/10/amgen-reports-third-quarter-2020-financial-results
  31. https://www.ema.europa.eu/en/medicines/human/paediatric-investigation-plans/emea-002910-pip01-20
  32. https://www.clinicaltrialsregister.eu/ctr-search/trial/2019-003688-23/results
  33. https://blueripple.com/lpa/lpa-emerging-therapies/
  34. https://dataintelo.com/report/lipoproteina-lowering-therapies-market
  35. https://pmc.ncbi.nlm.nih.gov/articles/PMC12282488/
  36. https://www.annualreviews.org/content/journals/10.1146/annurev-pharmtox-031023-100609
  37. https://onlinelibrary.wiley.com/doi/10.1111/eci.70079
  38. https://pmc.ncbi.nlm.nih.gov/articles/PMC12314393/
  39. https://www.jacc.org/doi/10.1016/j.jacc.2023.02.033
  40. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.124.069210
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