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The company's major products are Prolia and XGEVA (Denosumab) for treatment of osteoporosis and bone diseases ($6.7 billion in total 2024 revenues), Enbrel (Etanercept) for treatment of autoimmune diseases ($3.3 billion in 2024 revenues), Repatha (evolocumab) for treatment of hyperlipidemia ($2.3 billion in 2024 revenues), Otezla (apremilast) for treatment of psoriasis and psoriatic arthritis ($2.1 billion in 2024 revenues), Tepezza (teprotumumab) to treat Graves' ophthalmopathy ($1.8 billion in 2024 revenues), Evenity (romosozumab) to treat osteoporosis ($1.5 billion in 2024 revenues), Kyprolis (carfilzomib) to treat cancer ($1.5 billion in 2024 revenues), Nplate (romiplostim) to regulate platelet production ($1.4 billion in 2024 revenues), and Aranesp (darbepoetin alfa) to stimulate erythropoiesis ($1.3 billion in 2024 revenues).[1]
Amgen has 17 clinical programs underway in Phase III, eight in Phase II, and 19 in Phase I. Its pipeline includes MariTide, an anti-obesity medication administered once per month by injection.[2]
AMGen corporate logo, 1983Argentine president Mauricio Macri meets with heads of Amgen, in 2018.
In April 1980, Amgen was founded in Thousand Oaks as Applied Molecular Genetics.[5] Amgen was backed by a small group of venture capitalists, and its early focus was on recombinant DNA technology and recombinant human insulin.[6]
In June 1984, Amgen and Kirin formed a joint venture giving Kirin the rights to Epogen in Japan.[14][15] A year later, Amgen researcher Larry Souza and his team cloned granulocyte colony-stimulating factor (G-CSF), leading to the development of Neupogen (filgrastim).[13][16][17]
In October 1988, Gordon Binder was named CEO, succeeding George Rathmann.[18] The following year, in 1989, Amgen received approval for the first recombinant human erythropoetin product, Epogen (epoetin alfa).[19]
In February 1991, Amgen received FDA approval for Neupogen for the prevention of infections in patients whose immune systems are suppressed due to cancer chemotherapy.[20]
Amgen opened a new manufacturing facility in Puerto Rico, in March 1993, which later became the company's flagship manufacturing site.[21]
In 1994, Amgen became the fifth company to receive the National Medal of Technology and Innovation from the United States Department of Commerce, in recognition of its work developing medicines to improve quality of life for kidney and cancer patients.[22] Also around this time, Amgen researcher Steve Elliott and his team added more sugar molecules to erythropoietin, causing it to remain in the body longer. This led to the development of Aranesp (darbepoetin alfa).[23]
Binder was succeeded as CEO by Kevin W. Sharer in 2000.[24] Robert A. Bradway became Amgen's president and chief executive officer in May 2012, following Sharer's retirement.[25]
In June 2010, Amgen received approval by the Food and Drug Administration for Prolia, a protein drug for the treatment of post-menopausal osteoporosis.[26] In clinical trials, Prolia reduced the rate of vertebral fractures by 61% and the risk of hip fractures by 40%.[27] In November 2010, the FDA approved Xgeva for the prevention of complications of bone metastases in patients with solid tumors.[28] The clinical trials primarily enrolled patients with breast or prostate cancer.
In March 2011, Amgen acquired a manufacturing facility near Dublin, Ireland.[29]
Amgen opened an affiliate in China in 2013.[30][31]
In November 2014, the company halted all trials of rilotumumab in advanced gastric cancer patients after one of the trials found more deaths in those who took the compound with chemotherapy, than those without.[32] Also in November 2014, the company, in conjunction with AstraZeneca, reported positive results for brodalumab in a Phase III trial comparing the compound with ustekinumab and a placebo in treating psoriasis.[33] In the same month, construction was completed on Amgen's next-generation biomanufacturing facility in Singapore.[34] Blincyto (blinatumomab) was approved by the FDA in December of that year.[35][36]
In March 2015, the company announced that it would license its Phase II candidate drug AMG 714 to Celimmune, which will develop the anti-IL-15 monoclonal antibody for treatment against diet nonresponsive celiac disease and refractory celiac disease.[37] In August 2015, Repatha (evolocumab) was approved by the FDA.[38]
In September 2016, the company announced it would purchase the rights to Boehringer Ingelheims Phase I bispecific T-cell engager compound (BI 836909, now AMG 420) for use in the treatment of multiple myeloma.[39] Also in September, the FDA approved Amjevita (adalimumab-atto).[40] The FDA approved Parsabiv in February 2017[41] and Mvasi (bevacizumab-awwb) in September.[42]
In January 2019, Evenity (romosozumab) received approval in Japan,[45][46] followed by FDA approval in April.[47] In June, Kanjinti (trastuzumab-anns) was approved by the FDA.[48]
In December 2019, the FDA approved Avsola (infliximab-axxq).[49]
In August 2020, Amgen, Takeda Pharmaceutical Company, and AbbVie, as part of a COVID-19 research and development (R&D) alliance, announced the first patients enrolled in the I-SPY COVID clinical trial. The trial evaluated the efficacy of Otezla and two other medicines in severely ill, hospitalized COVID-19 patients who required high-flow oxygen.[54]
In September 2020, Amgen and Eli Lilly and Company announced a global manufacturing collaboration for COVID-19 antibody therapies.[55]
In October 2020, Amgen announced positive topline Phase 2 results from the CodeBreaK 100 clinical study, evaluating sotorasib in 126 patients with KRAS G12C-mutant advanced NSCLC who had failed three or fewer prior lines of anti-cancer therapies (including immunotherapy and/or chemotherapy).[56] Amgen, the Global Coalition for Adaptive Research, and Eisai Co., Ltd. also announced enrollment of the first patient in a study testing multiple interventions for the treatment of patients hospitalized with COVID-19.[57]
In November 2020, Amgen, Takeda, and UCB, as part of the COVID R&D alliance, announced the first patient enrolled in another trial evaluating Otezla and two other drugs as treatments for COVID-19.[58] Amgen also announced that it would terminate its collaboration with Cytokinetics and transition the development and commercialization rights for omecamtiv mecarbil and AMG 594.[59] Amgen and AstraZeneca announced positive topline results from a Phase 3 trial in which the investigational medicine tezepelumab demonstrated a statistically significant reduction in exacerbations in patients with severe asthma.[60]
In December 2020, the FDA granted breakthrough therapy designation to sotorasib for advanced or metastatic non-small cell lung cancer patients with KRAS G12C mutation.[61] Also in December 2020, the FDA approved Riabni (rituximab-arrx), a biosimilar to Rituxan.[62][63]
In April 2021, the company acquired Five Prime Therapeutics and its lead candidate, bemarituzumab, for $1.9 billion.[64][65][66][67]
In the March 2021, Amgen acquired Rodeo Therapeutics for $720 million.[68][69]
In May 2021, sotorasib received accelerated approval from FDA for treatment of adult patients with NSCLC whose tumors have a KRAS G12C mutation and who have received at least one prior systemic therapy; this was the first approved targeted therapy for tumors with any KRAS mutation.[70] Similar approvals for sotorasib in NSCLC followed in January 2022 in Europe[71] and Japan.[72] The FDA approved Amgen's Lumakras in May for treatment of patients with KRAS-G12C-mutated non-small cell lung cancer.[73]
In June 2021, Amgen and Kyowa Kirin announced joint plans to develop and commercialize a treatment for atopic dermatitis.[74] In October, Amgen and Neumora Therapeutics announced a research and development collaboration focused on novel precision therapies for certain brain diseases.[75][76] Amgen began construction on a new biomanufacturing plant in New Albany, Ohio, in November.[77] In December, the FDA approved Amgen and AstraZeneca's Tezspire (tezepelumab) for severe asthma.[78] The FDA also approved Amgen's Otezla for adults with plaque psoriasis of any severity level.[79]
Amgen announced a research collaboration in January 2022 with Generate Biomedicines across multiple modalities and several therapeutic areas for up to $1.9 billion.[80][81] The company also launched a multi-target collaboration with Arrakis Therapeutics to identify novel targeted RNA degrader therapeutics.[82][83] The next month, Amgen entered a multi-year collaboration with Plexium to discover novel targeted protein degradation therapies.[84][85] Also in February, Amgen issued its first green bond to fund various environmentally friendly initiatives across the company.[86][87] The company broke ground on a new manufacturing facility in Holly Springs, North Carolina, in March.[88][89]
In September 2022, data from a late-stage study showed the company's cancer pill Lumakras (sotorasib) beating out chemotherapy. This was the first approved drug in the set of treatments that target KRAS, among the most common generic mutations found in cancers. The drug was approved in 2021 with a list price of $17,900 per month.[90]
In October 2022, the company acquired ChemoCentryx, the maker of Tavneos—a drug treatment for rare diseases called anti-neutrophil cytoplasmic autoantibody-associated vasculitis, for $3.7 billion in an all-cash deal.[91][92][93]
In October 2023, Amgen acquired Horizon Therapeutics, specializing in drugs for rare diseases, for $27.8 billion.[94][95]
Also in March 2025, Amgen announced the start of two late-stage trials for MariTide, an anti-obesity medication candidate.[98][99] In June 2025, the company noted that it had to reduce the dosage of the drug to avoid side effects such as vomiting.[100] However, patients that continued to take the drug lost approximately 20% of their body weight.[101]
In April 2025, the company announced a $900 million expansion of its facility in New Albany, Ohio.[102]
In October 2017, the Amgen Foundation pledged $3 million to Khan Academy to support the development of free online biology lessons.[115][116] In July 2020, Amgen granted an additional $3 million Khan Academy to support educational equity and science learning.[117][118]
In January 2020, the Amgen Foundation and Harvard University debuted LabXchange, a free online science education platform.[119][120] Amgen and the Amgen Foundation announced a commitment of up to $12.5 million to support COVID-19 relief efforts in March.[121]
In November 2021, Amgen awarded a $2 million grant to the CDC Foundation to launch the latter's EmPOWERED Health Program, promoting patient engagement in decision making for cancer treatments.[122]
The company spends approximately $10 million per year on lobbying in the United States. Political contributions have mostly been to individuals and organizations associated with the Democratic Party.[123]
Imlygic (talimogene laherparepvec) for local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in melanoma recurrent after initial surgery (FDA approved October 2015)[127]
Xgeva (denosumab) for the prevention of skeletal-related events (pathological fracture, radiation to bone, spinal cord compression or surgery to bone in adults with bone metastases from solid tumors)
In December 2012, Amgen plead guilty and agreed to pay $150 million in criminal penalty and $612 million to resolve 11 related whistleblower complaint related to improper marketing of anemia drug Aranesp. According to the United States Department of Justice, Amgen sold the drug for off-label uses at dosages that the FDA had rejected or never approved.[138][139]
In May 2025, a jury ruled that Amgen owes Regeneron $406 million for engaging in anticompetitive practices to increase sales of its cholesterol-reduction drug Repatha at the expense of Regeneron's Praluent.[140]
