Panthera Corporation, or Panthera, is a charitable organization devoted to preserving wild cats and their ecosystems around the globe. Founded in 2006, Panthera is devoted to the conservation of the world's 40 species of wild cats and the vast ecosystems they inhabit. Their team of biologists, data scientists, law enforcement experts and wild cat advocates studies and protects the seven species of big cats: cheetahs, jaguars, leopards, lions, pumas, snow leopards and tigers. Panthera also creates targeted conservation strategies for the world's most threatened and overlooked small cats, such as fishing cats, ocelots and Andean cats. The organization has offices in New York City and Europe, as well as offices in Mesoamerica, South America, Africa and Asia.

Panthera works in partnership with local and international NGOs, scientific institutions, corporate partner and government agencies to develop and implement range-wide species conservation strategies. It has funded the Wildlife Conservation Research Unit at Oxford University, with a diploma program in international wildlife practice. The organization also awards a number of grants to support promising field conservationists. These grant programs include the Kaplan Graduate Awards, the Research and Conservation Grants, the Small Cat Action Fund, the Sabin Snow Leopard Grant Program and the Winston Cobb Memorial Fellowships.

Panthera was co-founded in 2006 by American scientist Alan Rabinowitz and American entrepreneur Thomas S. Kaplan.

Kaplan served as Chairman of Panthera's Board of Trustees, succeeded in 2021 by Jonathan Ayers. Kaplan currently is Chairman of The Global Alliance for Wild Cats. Rabinowitz was the first President and CEO from 2001 until 2017 when he was succeeded by French scientist Fred Launay. Dr. Rabinowitz helped establish the world's first jaguar preserve in 1986, in Belize, and was the main driving force behind the Jaguar Corridor that connects jaguar populations across its range, from Mexico to Argentina.

In 2014 Kaplan and his wife Daphne Recanati Kaplan pledged $20 million over 10 years to fund the organization. The couple were joined by H.H. Sheikh Mohamed bin Zayed Al Nahyan, Jho Low and Hemendra Kothari each who each pledged the same amount to support the organization.

John Goodrich leads Panthera's Tiger Program and serves as Chief Scientist. Kim Young-Overton serves as Director of Panthera's Cheetah Program, and Gareth Mann is Director of Panthera's Leopard Program. Additionally, Byron Weckworth is the Director of the Snow Leopard Program, Wai-Ming Wong is Director of the Small Cats Program and Mark Elbroch is the Director of the Puma Program. Howard Quigley joined the organization in 2009 and is currently the Director of its Jaguar Program.

In South America, Mesoamerica and Mexico, Panthera is developing a transnational corridor to help protect the jaguar. Jaguar survival and health depends on a network of corridors that span the continent, while past efforts focused on developing distinct sanctuaries. It is the jaguar's ability to travel long distances that prevents inbreeding and consequent extinction.

In August 2010, in Belize, Panthera worked with the government to create the Labouring Creek Jaguar Corridor Wildlife Sanctuary, with more than 7,000 acres (28 km²) of land. The project is part of the Panthera Jaguar Corridor Initiative. In Costa Rica, it is researching the routes that jaguars travel, and encouraging politicians and developers to respect those routes. They are also sponsoring community outreach programs to alleviate "jaguar conflict issues". In Mesoamerica and North America, Panthera also works in Mexico, Guatemala, Honduras and Nicaragua, in addition to its ongoing work in Belize and Costa Rica.