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Para-Iodoamphetamine
para-Iodoamphetamine (PIA), also known as 4-iodoamphetamine (4-IA), is a monoamine releasing agent (MRA) and serotonergic neurotoxin of the amphetamine family related to para-chloroamphetamine (PCA).
PIA acts as a serotonin releasing agent (SRA). In animal drug discrimination tests, PIA fully substitutes for MDMA and (+)-MBDB.
It also has very low affinity for certain serotonin receptors, including the serotonin 5-HT1 receptor (Ki = 7,660 nM) and the serotonin 5-HT2 receptor (Ki = 43,000 nM).
PIA has been described as having either similar serotonergic neurotoxicity as PCA or as having much weaker serotonergic neurotoxicity than PCA.
PIA, also known as 4-iodoamphetamine, is a phenethylamine and amphetamine derivative and a para-halogenated amphetamine.
PIA is closely related to other para-halogenated amphetamines such as PCA, para-bromoamphetamine (PBA), and para-fluoroamphetamine (PFA).
Iofetamine, also known as N-isopropyl-(123I)-para-iodoamphetamine, is a derivative of PIA used as a radiopharmaceutical and diagnostic agent.
5-Iodo-2-aminoindane (5-IAI), the 2-aminoindane analogue of PIA, was an attempt to make a non-neurotoxic analogue of PIA that proved to be less neurotoxic.
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Para-Iodoamphetamine
para-Iodoamphetamine (PIA), also known as 4-iodoamphetamine (4-IA), is a monoamine releasing agent (MRA) and serotonergic neurotoxin of the amphetamine family related to para-chloroamphetamine (PCA).
PIA acts as a serotonin releasing agent (SRA). In animal drug discrimination tests, PIA fully substitutes for MDMA and (+)-MBDB.
It also has very low affinity for certain serotonin receptors, including the serotonin 5-HT1 receptor (Ki = 7,660 nM) and the serotonin 5-HT2 receptor (Ki = 43,000 nM).
PIA has been described as having either similar serotonergic neurotoxicity as PCA or as having much weaker serotonergic neurotoxicity than PCA.
PIA, also known as 4-iodoamphetamine, is a phenethylamine and amphetamine derivative and a para-halogenated amphetamine.
PIA is closely related to other para-halogenated amphetamines such as PCA, para-bromoamphetamine (PBA), and para-fluoroamphetamine (PFA).
Iofetamine, also known as N-isopropyl-(123I)-para-iodoamphetamine, is a derivative of PIA used as a radiopharmaceutical and diagnostic agent.
5-Iodo-2-aminoindane (5-IAI), the 2-aminoindane analogue of PIA, was an attempt to make a non-neurotoxic analogue of PIA that proved to be less neurotoxic.