Pimethixene

Pimethixene

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral, nasal
ATC code	R06AX23 (WHO)
Identifiers
IUPAC name 1-Methyl-4-(9H-thioxanthen-9-ylidene)piperidine
CAS Number	314-03-4 N
PubChem CID	4822
ChemSpider	4656 Y
UNII	T46J20J26F
KEGG	D07406 Y
ChEMBL	ChEMBL152408 Y
CompTox Dashboard (EPA)	DTXSID0048476
ECHA InfoCard	100.005.675
Chemical and physical data
Formula	C19H19NS
Molar mass	293.43 g·mol−1
3D model (JSmol)	Interactive image
SMILES S2c1ccccc1/C(c3c2cccc3)=C4/CCN(C)CC4
InChI InChI=1S/C19H19NS/c1-20-12-10-14(11-13-20)19-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)19/h2-9H,10-13H2,1H3 Y Key:NZLVRVYNQYGMAB-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Pimethixene is an antihistamine and anticholinergic of the thioxanthene chemical class originally developed to treat hyperactivity,^[1] anxiety, sleep disorders, and allergy. It is also used for anesthesia and as a bronchodilator (to dilate the bronchi and bronchioles for more airflow).

In combination with pholcodine, it was sold in France by Laboratoires Salvoxyl in the 1970s as the antitussive Salvodex.^[2] Pimethixene alone is still available in Brazil under the trade name Muricalm.

In addition to its other activities, it is a highly potent but non-selective serotonin 5-HT_2B receptor antagonist.^[3] The selective serotonin 5-HT_2B receptor antagonist BF-1 was derived from pimethixene.^[3]

1. ^ Chefneux A (July 1978). "[New treatment of hyperkinesis in the child: pimethixene]". Revue Médicale de Liège. 33 (14): 500–3. PMID 674966.
2. ^ Bailly, Christian (8 December 2020). "Salvodex® (9-(1-methyl, 4-piperylidenyl)thiaxanthene and pholcodine), from Laboratoires Salvoxyl (Orléans), 1971". Oncowitan. Retrieved 4 January 2022.
3. ^ ^{a b} Schmitz B, Ullmer C, Segelcke D, Gwarek M, Zhu XR, Lübbert H (March 2015). "BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs". Eur J Pharmacol. 751: 73–80. doi:10.1016/j.ejphar.2015.01.043. PMID 25666387.

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