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Plasmepsin II
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| Plasmepsin II | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifiers | |||||||||
| EC no. | 3.4.23.39 | ||||||||
| CAS no. | 159447-18-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Plasmepsin II (EC 3.4.23.39, aspartic hemoglobinase II, PFAPD) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe-Phe(NO2)-Ser-Phe-Pro-Thr
This enzyme is present in malaria organism, Plasmodium.
References
[edit]- ^ Dame JB, Reddy GR, Yowell CA, Dunn BM, Kay J, Berry C (April 1994). "Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum". Molecular and Biochemical Parasitology. 64 (2): 177–90. doi:10.1016/0166-6851(94)90024-8. PMID 7935597.
- ^ Gluzman IY, Francis SE, Oksman A, Smith CE, Duffin KL, Goldberg DE (April 1994). "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". The Journal of Clinical Investigation. 93 (4): 1602–8. doi:10.1172/JCI117140. PMC 294190. PMID 8163662.
- ^ Hill J, Tyas L, Phylip LH, Kay J, Dunn BM, Berry C (September 1994). "High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum". FEBS Letters. 352 (2): 155–8. Bibcode:1994FEBSL.352..155H. doi:10.1016/0014-5793(94)00940-6. PMID 7925966.
External links
[edit]- Plasmepsin+II at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
