SLC27A3

SLC27A3
Identifiers
Aliases	SLC27A3, ACSVL3, FATP3, VLCS-3, solute carrier family 27 member 3
External IDs	OMIM: 604193; MGI: 1347358; HomoloGene: 11529; GeneCards: SLC27A3; OMA:SLC27A3 - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,780,157 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,297,245 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; Descending thoracic aorta; ; ascending aorta; ; right lung; ; gastric mucosa; ; right coronary artery; ; subcutaneous adipose tissue; ; upper lobe of left lung; ; left coronary artery; ; monocyte;
	Top expressed in
	yolk sac; ; adrenal gland; ; lip; ; renal corpuscle; ; otic vesicle; ; embryo; ; urethra; ; tail of embryo; ; embryo; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	long-chain fatty acid-CoA ligase activity; nucleotide binding; ligase activity; catalytic activity; very long-chain fatty acid-CoA ligase activity; long-chain fatty acid transporter activity; ATP binding;
Cellular component	integral component of membrane; membrane; mitochondrial membranes; mitochondrion; endoplasmic reticulum;
Biological process	metabolism; long-chain fatty acid metabolic process; fatty acid metabolic process; lipid metabolism; long-chain fatty acid transport;
	Sources:Amigo / QuickGO
Orthologs
	11000
	26568
	ENSG00000263163; ENSG00000143554
	ENSMUSG00000027932
	Q5K4L6
	O88561
	NM_024330; NM_001317929
	NM_011988; NM_001316688
	NP_001304858; NP_077306
	NP_001303617; NP_036118
	Wikidata
View/Edit Human	View/Edit Mouse

Long-chain fatty acid transport protein 3 is a protein that in humans is encoded by the SLC27A3 gene.^[5]^[6]

In melanocytic cells SLC27A3 gene expression may be regulated by MITF.^[7]

References

^ ^a ^b ^c ENSG00000143554 GRCh38: Ensembl release 89: ENSG00000263163, ENSG00000143554 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027932 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hirsch D, Stahl A, Lodish HF (Aug 1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proc Natl Acad Sci U S A. 95 (15): 8625–9. Bibcode:1998PNAS...95.8625H. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728.
^ "Entrez Gene: SLC27A3 solute carrier family 27 (fatty acid transporter), member 3".
^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Pei Z, Fraisl P, Berger J, et al. (2005). "Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells". J. Biol. Chem. 279 (52): 54454–62. doi:10.1074/jbc.M410091200. PMID 15469937.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] ENSG00000143554 GRCh38: Ensembl release 89: ENSG00000263163, ENSG00000143554 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027932 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9671728-5] Hirsch D, Stahl A, Lodish HF (Aug 1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proc Natl Acad Sci U S A. 95 (15): 8625–9. Bibcode:1998PNAS...95.8625H. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728.

[entrez-6] "Entrez Gene: SLC27A3 solute carrier family 27 (fatty acid transporter), member 3".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

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