Sanjay Gupta (born October 23, 1969) is an American neurosurgeon, medical reporter, and writer. He serves as an associate chief of the neurosurgery service at Grady Memorial Hospital in Atlanta, Georgia, an associate professor of neurosurgery at the Emory University School of Medicine, a member of the National Academy of Medicine, a member of the American Academy of Arts and Sciences, and the chief medical correspondent for CNN.

Gupta is known for his many television appearances on health-related issues. During the COVID-19 pandemic, he has been a frequent contributor to numerous CNN shows covering the crisis, as well as hosting a weekly town hall with Anderson Cooper. Gupta was the host of the CNN show Sanjay Gupta MD for which he has won multiple Emmy Awards. Gupta also hosted the 6-part miniseries Chasing Life. He is a frequent contributor to other CNN programs such as American Morning, Larry King Live, CNN Tonight, and Anderson Cooper 360°. His reports from Charity Hospital, New Orleans, Louisiana, in the wake of Hurricane Katrina led to his winning a 2006 Emmy Award for Outstanding Feature Story in a Regularly Scheduled Newscast. He is also a special correspondent for CBS News.

Sanjay Gupta also co-hosts the health conference Life Itself, along with Marc Hodosh (co-creator of TEDMED). Gupta published a column in Time magazine and has written four books: Chasing Life, Cheating Death, Monday Mornings: A Novel, and Keep Sharp (January 2021).

Gupta was born in Novi, Michigan, a suburb of Detroit. In the 1960s, Gupta's parents, Subhash and Damyanti Gupta (née Hingorani), both moved from India prior to their marriage and met in Livonia, Michigan, where they worked as engineers for Ford Motor Company. His mother was born in the village of Tharushah in Sindh (now Pakistan), but at age 5 fled to Baroda, India, as a Hindu refugee during the Partition of India. Gupta and his younger brother Suneel graduated from Novi High School; Gupta went on to receive his Bachelor of Science degree in biomedical sciences at the University of Michigan in Ann Arbor, and his M.D. degree from the University of Michigan Medical School in 1993. He was part of Inteflex, a since-discontinued accelerated medical education program that accepted medical students directly from high school.

As an undergraduate, Gupta worked as an orientation leader for the first-year orientation program and was a member of the Men's Glee Club. He also served as president of the Indian American Students Association (IASA), one of the university's larger student organization. Gupta completed his residency in neurological surgery within the University of Michigan Health System in 2000, followed by a fellowship at the Semmes Murphy Clinic, in Memphis, Tennessee. Gupta plays the accordion, having taken ten years of lessons, as he noted in an interview with David Hochman for Playboy.

Gupta was a White House Fellow in 1997–1998.

Gupta is an Emory Healthcare general neurosurgeon at Grady Memorial Hospital and has worked on spine, trauma, and 3‑D‑image-guided operations. He has published medical journal articles on percutaneous pedicle screw placement, brain tumors, and spinal cord abnormalities. He is licensed to practice medicine in Georgia. From 1997 to 1998, he served as one of fifteen White House Fellows, primarily as an advisor to Hillary Clinton. In January 2009, it was reported that Gupta was offered the position of Surgeon General of the United States in the Obama Administration, but he withdrew his name from consideration.

During his reporting in Haiti following the January 2010 earthquake, Gupta received a call from the aircraft carrier USS Carl Vinson that an earthquake victim, a 12-year-old girl, was aboard and needed a neurosurgeon. Gupta, a pediatric surgeon, Henri Ford, and two U.S. Navy doctors removed a piece of concrete from the girl's skull in an operation performed aboard the Vinson. Ford later wrote that Gupta "proved to be a competent neurosurgeon".