The Santa Ana winds, occasionally referred to as the devil winds, are strong, extremely dry katabatic winds that originate inland and affect coastal Southern California and northern Baja California. They originate from cool, dry high-pressure air masses in the Great Basin.

Santa Ana winds are known for the hot, dry weather that they bring in autumn (often the hottest of the year), but they can also arise at other times of the year. They often bring the lowest relative humidities of the year to coastal Southern California, and "beautifully clear skies". These low humidities, combined with the warm, compressionally-heated air mass and high wind speeds, create critical fire weather conditions that fan destructive wildfires.

Typically, about 10 to 25 Santa Ana wind events occur annually. A Santa Ana wind can blow from one to seven days, with an average wind event lasting three days. The longest recorded Santa Ana event was a 14-day wind in November 1957. Damage from high winds is most common along the Santa Ana River basin in Orange County, the Santa Clara River basin in Ventura and Los Angeles County, through Newhall Pass into the San Fernando Valley of Los Angeles County, and through the Cajon Pass into San Bernardino County near San Bernardino, Fontana, and Chino.

The Santa Ana Winds drive most wildfires in Southern California. Most recently, the winds are known as the force behind the January 2025 Southern California wildfires, having gone on and off for 24 days, starting on January 6th, 2025 and ending on January 31st.

The Santa Anas are katabatic winds (Greek for "flowing downhill") arising in higher altitudes and blowing down towards sea level. The National Weather Service defines Santa Ana winds as "a weather condition [in southern California] in which strong, hot, dust-bearing winds descend to the Pacific Coast around Los Angeles from inland desert regions".

Santa Ana winds originate from high-pressure airmasses over the Great Basin and upper Mojave Desert. Any low-pressure area over the Pacific Ocean, off the coast of California, can change the stability of the Great Basin High, causing a pressure gradient that turns the synoptic scale winds southward down the eastern side of the Sierra Nevada and into the Southern California region. According to one meteorology journal, "a popular rule of thumb used by forecasters is to measure the difference in pressure between the Los Angeles International Airport and Las Vegas; a difference of 9 millibars (0.27 inches of mercury) is enough to support a Santa Ana event." Dry air flows outward in a clockwise spiral from the high pressure center. This dry airmass sweeps across the deserts of eastern California toward the coast, and encounters the towering Transverse Ranges, which separate coastal Southern California from the deserts. The airmass, flowing from high pressure in the Great Basin to a low pressure center off the coast, takes the path of least resistance by channeling through the mountain passes to the lower coastal elevations, as the low pressure area off the coast pulls the airmass offshore.

Mountain passes which channel these winds include the Soledad Pass, the Cajon Pass, and the San Gorgonio Pass, all well known for increasing Santa Anas as they are funneled through. This increase in speed, often to near-gale force or above is due to the Venturi effect of the passes. At the same time, as the air descends from higher elevation to lower, the temperature and barometric pressure increase adiabatically, warming about 5 °F for each 1,000 feet it descends (1 °C for each 100 m). Relative humidity decreases with the increasing temperature. The air has already been dried by orographic lift before reaching the Great Basin, as well as by subsidence from the upper atmosphere, so this additional warming often causes relative humidity to fall below 10 percent.

The end result is a strong, warm, and very dry wind blowing out of the bottom of mountain passes into the valleys and coastal plain. These warm, dry winds, which can easily exceed 40 miles per hour (64 km/h), can severely exacerbate brush or forest fires, especially under drought conditions.