South Carolina State University (SCSU or SC State) is a public, historically black, land-grant university in Orangeburg, South Carolina. It is the only public, historically black land-grant research university in South Carolina, is a member of the Thurgood Marshall College Fund, and is accredited by the Southern Association of Colleges and Schools (SACS).

The university's beginnings were as the South Carolina Agricultural and Mechanical Institute in 1872 in compliance with the 1862 Land Grant Act within the institution of Claflin College—now known as Claflin University.

In 1896 the South Carolina General Assembly passed an act of separation and established a separate institution – the Colored Normal Industrial Agricultural and Mechanical College of South Carolina, its official name until 1954.

Academic programs received more attention as the student population increased, but other programs, such as the university's high school, were forced to close due to the Great Depression. The New Deal Programs were used to create, among other things, Wilkinson Hall, the university's first separate library building (now home to Admissions and Financial Aid).

The college's campus grew, as it purchased over 150 acres (61 ha) for agricultural learning. After World War II, many students flocked to the college, creating a classroom shortage problem for the school. In 1947, the United States Army created an ROTC detachment, in which all male students were required to enroll until mandatory enrollment ended in 1969.

The school's name changed, as well, as the South Carolina General Assembly renamed the school South Carolina State College in 1954. Because of the "separate but equal" laws in the state, the legislature gave the college large sums of money to build new academic facilities and dormitories, some of which still stand on the campus today, including the Student Union (1954), and Turner Hall (1956). This was done in order to give black students an environment of "equal" education. Also, the legislature created a law program for the college, mainly to prevent black students from attending the law school at the then-segregated University of South Carolina. The law program folded in 1966 after the University of South Carolina integrated.

During the height of the Civil Rights Movement, many students participated in marches and rallies aimed at ending segregation. The struggle came to a climax on the night on February 8, 1968, when three students were killed and 27 others were wounded by state policemen at the height of a protest that opposed the segregation of a nearby bowling alley. The tragedy, known as the Orangeburg massacre, is commemorated by a memorial plaza near the front of the campus.

From the late-1960s to the mid-1980s, under the leadership of M. Maceo Nance, the campus experienced unprecedented growth in the form of new academic buildings, such as Nance Hall (1974) and Belcher Hall (1986), new residence halls, such as Sojourner Truth Hall