Supersymmetry is a theoretical framework in physics that suggests the existence of a symmetry between particles with integer spin (bosons) and particles with half-integer spin (fermions). It proposes that for every known particle, there exists a partner particle with different spin properties. There have been multiple experiments on supersymmetry that have failed to provide evidence that it exists in nature. If evidence is found, supersymmetry could help explain certain phenomena, such as the nature of dark matter and the hierarchy problem in particle physics.

A supersymmetric theory is a theory in which the equations for force and the equations for matter are identical. In theoretical and mathematical physics, any theory with this property has the principle of supersymmetry (SUSY). Dozens of supersymmetric theories exist. In theory, supersymmetry is a type of spacetime symmetry between two basic classes of particles: bosons, which have an integer-valued spin and follow Bose–Einstein statistics, and fermions, which have a half-integer-valued spin and follow Fermi–Dirac statistics. The names of bosonic partners of fermions are prefixed with s-, because they are scalar particles. For example, if the electron existed in a supersymmetric theory, then there would be a particle called a selectron (superpartner electron), a bosonic partner of the electron.

In supersymmetry, each particle from the class of fermions would have an associated particle in the class of bosons, and vice versa, known as a superpartner. The spin of a particle's superpartner is different by a half-integer. In the simplest supersymmetry theories, with perfectly "unbroken" supersymmetry, each pair of superpartners would share the same mass and internal quantum numbers besides spin. More complex supersymmetry theories have a spontaneously broken symmetry, allowing superpartners to differ in mass.

Supersymmetry has various applications to different areas of physics, such as quantum mechanics, statistical mechanics, quantum field theory, condensed matter physics, nuclear physics, optics, stochastic dynamics, astrophysics, quantum gravity, and cosmology. Supersymmetry has also been applied to high-energy physics, where a supersymmetric extension of the Standard Model is a possible candidate for physics beyond the Standard Model. However, no supersymmetric extensions of the Standard Model have been experimentally verified, and some physicists are saying the theory is dead.

A supersymmetry relating mesons and baryons was first proposed, in the context of hadronic physics, by Hironari Miyazawa in 1966. This supersymmetry did not involve spacetime, that is, it concerned internal symmetry, and was broken badly. Miyazawa's work was largely ignored at the time.

J. L. Gervais and B. Sakita (in 1971), Yu. A. Golfand and E. P. Likhtman (also in 1971), and D. V. Volkov and V. P. Akulov (1972), independently rediscovered supersymmetry in the context of quantum field theory, a radically new type of symmetry of spacetime and fundamental fields, which establishes a relationship between elementary particles of different quantum nature, bosons and fermions, and unifies spacetime and internal symmetries of microscopic phenomena. Supersymmetry with a consistent Lie-algebraic graded structure on which the Gervais−Sakita rediscovery was based directly first arose in 1971 in the context of an early version of string theory by Pierre Ramond, John H. Schwarz and André Neveu.

In 1974, Julius Wess and Bruno Zumino identified the characteristic renormalization features of four-dimensional supersymmetric field theories, which identified them as remarkable QFTs, and they and Abdus Salam and their fellow researchers introduced early particle physics applications. The mathematical structure of supersymmetry (graded Lie superalgebras) has subsequently been applied successfully to other topics of physics, ranging from nuclear physics, critical phenomena, quantum mechanics to statistical physics, and supersymmetry remains a vital part of many proposed theories in many branches of physics.

In particle physics, the first realistic supersymmetric version of the Standard Model was proposed in 1977 by Pierre Fayet and is known as the Minimal Supersymmetric Standard Model or MSSM for short. It was proposed to solve, amongst other things, the hierarchy problem.