Traditional medicine (also known as indigenous medicine or folk medicine) refers to the knowledge, skills, and practices rooted in the cultural beliefs of various societies, especially Indigenous groups, used with the intent of treating illness and maintaining health.

In some Asian and African countries, up to 80% of people rely on traditional medicine for primary health care. Traditional medicine includes systems like Ayurveda, traditional Chinese medicine, and Unani. The World Health Organization supports their integration, but warns of potential risks and calls for more research on their safety and effectiveness.

The use of medicinal herbs spans over 5,000 years, beginning with ancient civilizations like the Sumerians, Egyptians, Indians, and Chinese, evolving through Greek, Roman, Islamic, and medieval European traditions, and continuing into colonial America, with beliefs passed down, translated, and expanded across cultures and centuries. Indigenous folk medicine is traditionally passed down orally within communities, often through designated healers like shamans or midwives, and remains practiced based on personal belief, community trust, and perceived effectiveness—even as broader cultural acceptance wanes.

Traditional medicine faces criticism due to absence of scientific evidence and safety concerns from unregulated natural remedies and the use of endangered animals, like slow lorises, sharks, elephants, and pangolins, which contributes to biodiversity loss and illegal wildlife trade.

In the written record, the study of herbs dates back 5,000 years to the ancient Sumerians, who described various medicinal uses for plants. In Ancient Egyptian medicine, the Ebers papyrus from c. 1552 BC records a list of folk remedies and magical medical practices.

Many herbs and minerals used in Ayurveda were described by ancient Indian herbalists such as Charaka and Sushruta during the 1st millennium BC. The first Chinese herbal book was the Shennong Bencaojing, compiled during the Han dynasty but dating back to a much earlier date, which was later augmented as the Yaoxing Lun (Treatise on the Nature of Medicinal Herbs) during the Tang dynasty. Early recognised Greek compilers of existing and current herbal knowledge include Pythagoras and his followers, Hippocrates, Aristotle, Theophrastus, Dioscorides and Galen.

Roman sources included Pliny the Elder's Natural History and Celsus's De Medicina. Pedanius Dioscorides drew on and corrected earlier authors for his De Materia Medica, adding much new material; the work was translated into several languages, and Turkish, Arabic and Hebrew names were added to it over the centuries. Latin manuscripts of De Materia Medica were combined with a Latin herbal by Apuleius Platonicus (Herbarium Apuleii Platonici) and were incorporated into the Anglo-Saxon codex Cotton Vitellius C.III. These early Greek and Roman compilations became the backbone of European medical theory and were translated by the Persian Avicenna (Ibn Sīnā, 980–1037), the Persian Rhazes (Rāzi, 865–925) and the Jewish Maimonides.

Some fossils have been used in traditional medicine since antiquity.