Valle del Cauca, or Cauca Valley (Spanish pronunciation: [ˈbaʎe ðel ˈkawka]), is a department in western Colombia abutting the Pacific Ocean. Its capital is Santiago de Cali. Other cities such as Buenaventura, Buga, Cartago, Palmira and Tuluá have great economical, political, social and cultural influence on the department's life. Valle del Cauca has the largest number of independent (i.e., nonmetropolitan) towns with over 100,000 inhabitants in the country, counting six within its borders. Buenaventura has the largest and busiest seaport in Colombia, moving about 8,500,000 tons of merchandise annually.

The department of Valle del Cauca is located in the western part of the country, between 3° 5′ N and 5° 1′ N latitude and 75° 42′ W and 77° 33′ W longitude. It borders the departments of Risaralda and Quindío to the north, Cauca to the south, Tolima to the east, and Chocó and the Pacific Ocean to the west. The valley is geographically bounded by the Cordillera Central and Occidental and is watered by numerous rivers that empty into the Cauca River. The department is divided into four zones: the Pacific Fringe, which is humid and mostly jungle; the western mountain range, also humid and full of jungle, heavily deforested because of the paper industry; the Andean valley of the Cauca River, whose surrounding lands are the most fertile in the country; and the western ridge of the Cordillera Central. Valle del Cauca also administers Malpelo Island in the Pacific.

Palynological analyses performed by experts have determined that during the Superior Pleistocene some 40,000–10,500 years ago, the valleys of El Dorado and Alto Calima had Andean forests and sub-Andean vegetation. The discovery of projectiles indicated that there were communities of hunter-gatherers at the end of the Pleistocene and the beginning of the Holocene. The extinction of the Pleistocenic megafauna in the beginning of the Holocene forced humans to adapt to their new environment, becoming hunter-gatherers. In the lower basin of the Calima River (Sauzalito River, El Recreo River, and El Pital River), archaeologists found the oldest traces of hunter-gatherers who inhabited the Valley of the Cauca River. According to these, in 5000 BC these societies already had some level of primitive agriculture and cultivated maize. There is little information about the years between 3000 and 1500 BC.

In 1500 BC the first agricultural–pottery society, the Ilama culture, appeared, extending along the Calima River (in what is now the towns of Restrepo and Darién). Its society had a social structure of cacicazgos ("chiefdoms") that prevailed until the arrival of the Spaniards. The Ilama economy was based on migratory agriculture using maize, yuca, and beans; hunting; fishing; textile manufacturing; and metallurgy. The chief or cacique was the head of the settlement and had chamanes ("spiritual leaders"), warriors, farmers, hunters, pottery men, and goldsmiths. By 100 AD, the Ilama had developed into the Yotoco, whom expanded the region of the Ilama further, down the Cauca River to the Pacific Ocean, and southward to the present-day region of Santiago de Cali (Cali).

The Yotoco were a highly stratified society, headed by caciques, who managed several settlements. They existed in the region until around 1200 AD. A rising population forced them to develop effective agricultural systems to meet food demand, which improved pottery and metalworking techniques. Yotoco agriculture — based on maize, yuca, beans, arracacha, and achiote, among other foods - was more diverse than that of the Ilama. The Yotoco experienced a decline beginning in the 6th century AD.

This archeological period is called the Late Period and is divided into Late Period I (6th to 13th centuries) and Late Period II (14th to 16th centuries). In Late Period I the Valle del Cauca region was inhabited by the early Sonso culture, Bolo, Sachamate, and La Llanada. During Late Period II the region was inhabited by the late Sonso culture, Pichinde, Buga, and Quebrada Seca. Their development is attributed to population growth. Almost all the settlers in the area became subject to the rule of one main cacique.

The first 67 Spanish explorers arrived in the area after founding the village of Popayán, in an expedition from Quito headed by Sebastián de Belalcázar. In the Valle del Cauca the explorers founded the village of Villa de Ampudia, named after one of them, Juan de Ampudia. By orders of Belalcázar the village was then moved to the Riviera of the Cauca River, within the Gorrones indigenous people's territory. In 1536, a Captain Muñoz ordered the city to be moved to the Valley, where the Village of Cali was founded on 25 July of that same year. Another Spanish explorer, Juan de Vadillo [es], coming from the village of Cartagena de Indias, entered Cali on 23 December 1538 with a second group of explorers, but he returned to Cartagena, leaving many of his men behind including Pedro Cieza de León. A third group of explorers, led by Admiral Jorge Robledo under orders of Lorenzo de Aldana [es], advanced to the North of the Valle del Cauca and founded the villages of Anserma (now part of Caldas Department; 15 August 1539), Cartago (9 August 1540), and Antioquia (25 November 1541), and under command of Pascual de Andagoya who came from Panama to Cali with a fourth group of explorers.

The Department of Valle del Cauca was created by decree number 340 on April 16, 1910, which created 12 other departments in Colombia. The Valle del Cauca Department was a result of the union of four former departments: Cartago, Buga, and Cali.