A vascular bypass is a surgical procedure performed to redirect blood flow from one area to another by reconnecting blood vessels. Often, this is done to bypass around a diseased artery, from an area of normal blood flow to another relatively normal area. It is commonly performed due to inadequate blood flow (ischemia) caused by atherosclerosis, as a part of organ transplantation, or for vascular access in hemodialysis. In general, someone's own vein (autograft) is the preferred graft material (or conduit) for a vascular bypass, but other types of grafts such as polytetrafluoroethylene (Teflon), polyethylene terephthalate (Dacron), or a different person's vein (allograft) are also commonly used. Arteries can also serve as vascular grafts. A surgeon sews the graft to the source and target vessels by hand using surgical suture, creating a surgical anastomosis.

Common bypass sites include the heart (coronary artery bypass surgery) to treat coronary artery disease, and the legs, where lower extremity bypass surgery is used to treat peripheral vascular disease.

Cardiac bypass is performed when the arteries that bring blood to the heart muscle (coronary arteries) become clogged by plaque. Such a condition may cause chest pain from angina pectoris or a heart attack. Dimensional aspects, material selection, and manufacturing methods influence mechanistic behaviours of artificial grafts and chosen to receive artery-like behaviour

In the legs, bypass grafting is used to treat peripheral vascular disease, acute limb ischemia, aneurysms and trauma. While there are many anatomical arrangements for vascular bypass grafts in the lower extremities depending on the location of the disease, the principle is the same: to restore blood flow to an area without normal flow.

For example, a femoral-popliteal bypass ("fem-pop") might be used if the femoral artery is occluded. A fem-pop bypass may refer to the above- or below-knee popliteal artery. Other anatomic descriptions of lower extremity bypasses include:

A vascular bypass is often created to serve as an access point to the circulatory system for hemodialysis. Such a bypass is referred to as an arteriovenous fistula if it directly connects a vein to an artery without using synthetic material.

In the skull, when blood flow is blocked or a damaged cerebral artery prevents adequate blood flow to the brain, a cerebral artery bypass may be performed to improve or restore flow to an oxygen-deprived (ischemic) area of the brain.

There are two main types of cerebral artery bypass: direct and indirect. Direct revascularization is also known as EC-IC bypass because it involves directly connecting an extracranial artery outside the brain to an intracranial artery inside the brain. This is also sometimes called STA-MCA bypass because the superficial temporal artery and the middle cerebral artery are the most commonly used arteries for the surgery. STA-MCA bypass surgery has been shown to be ineffective in reducing the risk of ischemic stroke in an international, randomized clinical trial. Indirect revascularization involves placing part of an artery, in the case of EDAS (encephaloduroarteriosynangiosis), or part of a muscle, in the case of EMS (encephalomyosynangiosis), on the surface of the brain and allowing it to revascularize the brain through new vessel growth. Both types of indirect revascularization typically take 3-6 months to see effects.