The House of Ypsilantis or Ypsilanti (Greek: Υψηλάντης; Romanian: Ipsilanti) was a Greek Phanariote family which grew into prominence and power in Constantinople during the last centuries of Ottoman Empire and gave several short-reign hospodars to the Danubian Principalities.

First mentioned in 1064, the family was originally from the village of İpsil (modern Arpaözü in the Çaykara district) in the Pontus region in the Black Sea, from which their surname is derived. They became prominent during the Empire of Trebizond. In 1655, Antiochus Ypsilantis left Trabzon and settled in Constantinople. Since the end of the Ottoman Empire, members of the Ypsilanti family can be found all over the world.