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MADNESS
MADNESS
MADNESS
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MADNESS
Original authorsGeorge Fann, Robert J. Harrison
DevelopersOak Ridge National Laboratory, Stony Brook University, Virginia Tech, Argonne National Laboratory
Initial releaseForthcoming
Stable release
0.10[1] / 6 July 2015; 10 years ago (6 July 2015)
Repository
TypeScientific simulation software
LicenseGNU GPL v2
Websitegithub.com/m-a-d-n-e-s-s/madness

MADNESS (Multiresolution Adaptive Numerical Environment for Scientific Simulation) is a high-level software environment for the solution of integral and differential equations in many dimensions using adaptive and fast harmonic analysis methods with guaranteed precision based on multiresolution analysis[2][3] and separated representations.[4]

There are three main components to MADNESS. At the lowest level is a petascale parallel programming environment[5] that aims to increases programmer productivity and code performance/scalability while maintaining backward compatibility with current programming tools such as the message-passing interface and Global Arrays. The numerical capabilities built upon the parallel tools provide a high-level environment for composing and solving numerical problems in many (1-6+) dimensions. Finally, built upon the numerical tools are new applications with initial focus upon chemistry,[6][7] atomic and molecular physics,[8] material science, and nuclear structure. It is open-source, has an object-oriented design, and is designed to be a parallel processing program for computers with up to millions of cores running already on the Cray XT5 at Oak Ridge National Laboratory and the IBM Blue Gene at Argonne National Laboratory. The small matrix multiplication (relative to large, BLAS-optimized matrices) is the primary computational kernel in MADNESS; thus, an efficient implement on modern CPUs is an ongoing research effort.[9][10] Adapting the irregular computation in MADNESS to heterogeneous platforms is nontrivial due to the size of the kernel, which is too small to be offloaded via compiler directives (e.g. OpenACC), but has been demonstrated for CPU–GPU systems.[11] Intel has publicly stated that MADNESS is one of the codes running on the Intel MIC architecture[12][13] but no performance data has been published yet.

MADNESS' chemistry capability includes Hartree–Fock and density functional theory in chemistry[14][15] (including analytic derivatives,[16] response properties[17] and time-dependent density functional theory with asymptotically corrected potentials[18]) as well as nuclear density functional theory[19] and Hartree–Fock–Bogoliubov theory.[20][21] MADNESS and BigDFT are the two most widely known codes that perform DFT and TDDFT using wavelets.[22] Many-body wavefunctions requiring six-dimensional spatial representations are also implemented (e.g. MP2[23]). The parallel runtime inside of MADNESS has been used to implement a wide variety of features, including graph optimization.[24] From a mathematical perspective, MADNESS emphasizes rigorous numerical precision without loss of computational performance.[25] This is useful not only in quantum chemistry and nuclear physics, but also the modeling of partial differential equations.[26]

MADNESS was recognized by the R&D 100 Awards in 2011.[27][28] It is an important code to Department of Energy supercomputing sites and is being used by both the leadership computing facilities at Argonne National Laboratory[29] and Oak Ridge National Laboratory[30] to evaluate the stability and performance of their latest supercomputers. It has users around the world, including the United States and Japan.[31] MADNESS has been a workhorse code for computational chemistry in the DOE INCITE program[32] at the Oak Ridge Leadership Computing Facility[33] and is noted as one of the important codes to run on the Cray Cascade architecture.[34]

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MADNESS

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Madness is a historical and cultural concept denoting severe disturbances in thought, emotion, and behavior that deviate markedly from societal norms of rationality and reality, often encompassing conditions now classified as mental illnesses such as schizophrenia or bipolar disorder. Throughout history, madness has been interpreted through diverse lenses, from ancient associations with divine punishment, mystical revelation, or demonic possession in biblical and pre-modern societies, to Enlightenment-era views that confined the "mad" in asylums as a means of social control. In the 19th century, it became medicalized, with psychiatrists like those authoring A Manual of Psychological Medicine (1858) classifying insanity into distinct types based on observable symptoms, marking the rise of professional "mad-doctors." The early 20th century shifted toward psychoanalysis, influenced by Sigmund Freud, which framed madness as rooted in unconscious conflicts and repressed traumas, a perspective dominant in North America until the 1970s. Post-1970s, contemporary psychiatry predominantly views madness as a brain disease stemming from genetic, neurochemical, or environmental factors, emphasizing pharmacological treatments over psychological exploration. This evolution reflects broader tensions between biological reductionism and sociocultural understandings, with madness portrayed as both a profoundly isolating affliction for individuals and a socially constructed phenomenon shaped by cultural contexts worldwide, including non-Western traditions in Islamic, Chinese, and Indian societies. Influential critiques, such as Michel Foucault's Madness and Civilization (1961), have highlighted how societal exclusion of the mad reinforces norms of reason, sparking anti-psychiatry movements.

Etymology and Conceptual Foundations

Origins of the Term

The term "madness" entered English in the late 14th century, denoting "insanity, lunacy, dementia; rash or irrational conduct, headstrong passion, extreme folly," derived by adding the suffix -ness to the adjective mad. The root mad traces to late 13th-century English usage meaning "disordered in intellect, demented, crazy, insane," stemming from Old English gemædde "out of one's mind," often implying violent excitement or foolishness. This Old English form is the past participle of a lost verb gemædan "to make insane," from Proto-Germanic gamaidjan, combining an intensive prefix ga- with maidaz "changed (for the worse), abnormal," ultimately from Proto-Indo-European moito-, past participle of mei-(1) "to change, go, move." While the English term evolved primarily through Germanic roots, it shares conceptual parallels with ancient Mediterranean languages. In Greek, manía referred to "madness, frenzy; enthusiasm, inspired frenzy; mad passion, fury," derived from mainesthai "to rage, go mad," entering Late Latin as mania "insanity, madness." No direct Latin antecedent like madius exists for the English mad, though Latin insania (from in- "not" + sanus "sane") captured similar ideas of mental unsoundness, influenced indirectly via shared Indo-European origins with concepts of change or aberration. These linguistic ties highlight early associations of madness with altered states, whether frenzied or irrational. Early textual examples in 14th-century English literature, such as Geoffrey Chaucer's The Canterbury Tales, depict madness as folly or divine retribution. In tales like "The Knight's Tale," characters exhibit mad passion driven by uncontrollable emotion, portraying it as a form of extreme foolishness or punishment for moral failings, reflecting medieval views of mental disorder as tied to sin or imbalance. Such usages underscore the term's shift from violent derangement to broader connotations of irrationality by the early 15th century. Cross-culturally, parallels appear in ancient Indian Sanskrit texts, where unmatta or unmāda described deranged or insane states, often linked to imbalance in bodily humors or divine influence. In medical compendia like the Charaka Samhita (circa 300 BCE–200 CE), unmāda denoted madness as a pathological frenzy, akin to Western frenzy concepts, with causes including possession or excess, illustrating universal early recognitions of mental aberration across traditions.

Philosophical Definitions

In ancient Greek philosophy, madness (mania) was conceptualized not merely as a pathological state but as a complex phenomenon involving disruptions to reason, potentially divine or detrimental. Plato, in his dialogue Phaedrus, distinguishes between harmful delusions arising from human disease or poor habits and beneficial forms of divine madness, which he portrays as a god-inspired enthusiasm (enthousiasmos) that elevates the soul. Socrates argues that this divine madness, far from being blameworthy, brings the greatest goods to humanity, countering earlier speeches that equated love-induced frenzy with loss of self-control (Plato, Phaedrus 244a–245c; Shelton 2024). He enumerates four types: prophetic madness from Apollo, enabling inspired oracles; ritualistic madness from Dionysus, purifying the soul of guilt; poetic madness from the Muses, displacing rational agency to allow creative inspiration; and the highest, erotic madness from Eros, which spurs philosophical recollection of eternal Forms, fostering the soul's godlike ascent (Plato, Phaedrus 265a–266b; Shelton 2024). This positive madness involves divine inhabitation without total irrationality, particularly in philosophy, where it aligns reason with transcendent truths, though it appears eccentric to the uninitiated multitude (Plato, Phaedrus 249c–e; Shelton 2024). Aristotle, building on Platonic ideas, addresses madness in the context of ethical psychology, emphasizing rational control (logos) over passions as central to human flourishing. In Nicomachean Ethics Book VII, he differentiates temporary folly or incontinence (akrasia)—where one knows the good but succumbs momentarily to overwhelming desires, akin to being "asleep, mad, or drunk"—from chronic insanity, which represents a profound, pathological loss of rational governance, placing it beyond ordinary vice on a continuum of soul disunity (Aristotle, Nicomachean Ethics 1147a10–23; Ahonen 2019). Aristotle views such extreme madness as arising when non-rational elements like disease or brutish impulses dominate, leading to actions "not naturally pleasant" that become so through morbid states, such as cannibalistic horrors, which exceed moral responsibility and invite treatment rather than blame (Aristotle, Nicomachean Ethics 1148b15–29; Frede 2013). This distinction underscores madness as a failure of the soul's unity, where reason fails to calibrate emotions and appetites appropriately, contrasting with virtuous equilibrium (Aristotle, Nicomachean Ethics 1106b; Frede 2013). In modern philosophy, Michel Foucault reframes madness as a historical and social construct, particularly in the Enlightenment era, where it served to exclude the "unreasonable" from the domain of rational discourse. In History of Madness (1961), Foucault argues that the Classical Age's confinement of the mad—initially as moral spectacles or wanderers—evolved into medicalized isolation, not as humanitarian progress but as a mechanism to enforce bourgeois rationality and silence deviations from normative reason (Foucault 2006). Madness thus becomes the constitutive "other" to Enlightenment thought, pathologized to preserve social order and knowledge production, transforming pre-modern views of cosmic tragedy into a binary of reason versus unreason that justified institutional control (Foucault 2006; Gutting 2023). This interpretation highlights madness not as an inherent disorder but as a discursive exclusion, critiquing psychiatry's claims to objectivity as veiled power dynamics (Foucault 2006; Gutting 2023).

Historical Perspectives on Madness

Ancient and Medieval Interpretations

In ancient Greece, madness was primarily understood through the lens of humoral theory, which posited that imbalances in the body's four humors—blood, phlegm, yellow bile, and black bile—caused physical and mental disorders. Hippocrates and his followers attributed melancholy, a form of madness characterized by despondency, suspicion, and withdrawal, to an excess of black bile (melaina kholē), described as a cold, dark fluid that disrupted mental equilibrium. This naturalistic explanation shifted focus from supernatural causes to physiological ones, viewing madness as a treatable illness rather than divine punishment, though black bile was also linked to more severe states like violent rage in non-Hippocratic texts. Biblical traditions in the New Testament often framed madness as demonic possession, where unclean spirits invaded the body, causing erratic behavior, self-harm, and supernatural outbursts, as exemplified in the Gerasene demoniac story where a man possessed by "Legion" lived among tombs and shattered chains (Mark 5:1-20). These accounts reflected popular folk beliefs attributing mental affliction to spiritual invasion, contrasting with emerging medical views and serving to stigmatize deviance as moral or supernatural failure. In Roman Stoicism, Seneca echoed this by portraying madness as the result of unchecked passions (pathē), such as anger (ira), which overpowered reason and induced instability akin to insanity (insania). For Stoics, all emotions were irrational disturbances of the soul, incompatible with wisdom, and thus a form of mental disease that sages avoided through disciplined self-control. During the medieval period in Europe, madness was increasingly interpreted as a moral or supernatural affliction tied to sin, demonic influence, or witchcraft, leading to custodial rather than curative approaches. The Priory of St. Mary of Bethlem, founded in 1247 outside London's walls as a religious hostel, evolved by the early 15th century into England's first dedicated asylum for the insane, providing basic shelter and spiritual guidance while employing restraints like chains and beatings to correct perceived moral failings. This reflected broader ecclesiastical views that equated madness with divine punishment or Satanic possession, often treated through prayer and exorcism rather than medicine. The overlap intensified during the witch hunts of the 15th to 17th centuries, where symptoms of madness—such as melancholy or fits—were sometimes attributed to witchcraft, resulting in trials and executions; for instance, cases like that of Mary Glover in 1602 saw her convulsions diagnosed by some as bewitchment rather than hysteria, fueling accusations against supposed sorcerers. Historians estimate 40,000 to 60,000 executions in this "witch craze," with madness and possession serving as diagnostic markers of demonic alliance, though contemporaries distinguished witches from the inherently mad.

Renaissance to Enlightenment Views

During the Renaissance and into the Enlightenment, perceptions of madness began transitioning from predominantly supernatural and moral explanations toward more humanistic, observational, and proto-scientific frameworks, emphasizing internal psychological and physiological causes. This period marked a growing interest in classifying mental disturbances as conditions amenable to rational inquiry rather than divine punishment or demonic influence. A seminal work in this evolution was Robert Burton's The Anatomy of Melancholy (1621), which provided one of the earliest comprehensive classifications of madness. Burton divided mental disorders into categories such as diseases of the body, brain afflictions, mania (characterized by furious rage and irrationality), and melancholy (involving persistent sorrow and fear linked to black bile). His text, drawing on classical humoral theory while incorporating contemporary observations, portrayed madness as a spectrum of imbalances influenced by bodily humors, diet, environment, and even astrological factors, advocating remedies like music, exercise, and empathetic conversation. Building on this, 17th-century physician Thomas Sydenham advanced empirical approaches to madness through meticulous clinical observations, rejecting speculative theories in favor of linking mental disturbances to tangible physical disorders. Known as the "English Hippocrates," Sydenham treated hysteria and hypochondria as akin nervous affections originating from corporeal imbalances, such as convulsions or spasms in the nervous system, rather than wandering wombs or purely psychological whims. In his Medical Observations (1676), he described these conditions as spasmodic disorders treatable with purgatives, bleeding, and lifestyle adjustments, emphasizing the unity of mind and body in pathology. This observational method influenced later medical practice by prioritizing symptom description and natural history over metaphysical causes. Enlightenment philosophers further refined these ideas, conceptualizing madness as a disruption in rational thought processes. John Locke, in An Essay Concerning Human Understanding (1690), posited that madness stemmed from faulty associations of ideas—unrelated concepts unnaturally linked by habit, chance, or education, overriding natural reason and leading to persistent irrationality. Locke argued this "degree of madness" was universal to some extent, treatable through vigilant education and breaking habitual mental patterns, as ideas once conjoined become inseparable without deliberate intervention. These views contributed to the establishment of early institutions for the mad, such as France's Bicêtre Hospital, incorporated into the Hôpital Général de Paris in 1656, which confined the insane alongside the poor and vagrants, marking a shift toward segregated management under emerging humanitarian ideals. Such developments laid foundational principles for modern psychiatry by promoting observation, classification, and institutional care over exorcism or punishment.

Medical and Psychological Frameworks

Classification and Diagnosis

In contemporary psychiatry, the term "madness" is not used as a formal diagnostic category but is often colloquially associated with severe psychotic experiences involving profound distortions of reality, such as persistent delusions and hallucinations that impair insight and functioning. Diagnostic frameworks like the DSM-5 and ICD-11 provide structured classifications to identify and differentiate these conditions, emphasizing observable symptoms and their impact on daily life. These systems distinguish primary psychotic disorders, where reality distortion is the core feature, from secondary psychotic symptoms that may occur in other conditions like mood disorders. The DSM-5 organizes psychotic conditions under the "Schizophrenia Spectrum and Other Psychotic Disorders" chapter, encompassing disorders such as schizophrenia, schizoaffective disorder, delusional disorder, brief psychotic disorder, and schizophreniform disorder. Schizophrenia, for instance, requires at least two characteristic symptoms (e.g., delusions, hallucinations, disorganized speech) for a significant duration, with at least one being delusions, hallucinations, or disorganized speech, alongside functional impairment and exclusion of substance-induced or medical causes. This contrasts with mood disorders like bipolar I disorder with manic episodes, where psychotic features (e.g., grandiose delusions) are typically mood-congruent and resolve with mood stabilization, rather than persisting independently as in primary psychotic disorders. Similarly, the ICD-11 classifies these under "Schizophrenia or other primary psychotic disorders," including schizophrenia, schizotypal disorder, acute and transient psychotic disorders, and induced delusional disorders, defined by the presence of delusions, hallucinations, or other reality-distorting experiences not better explained by mood or other conditions. Diagnostic criteria prioritize the primacy and persistence of psychotic symptoms, with mood episodes (as in bipolar mania) considered separately under "Mood disorders" unless psychosis dominates the clinical picture. Historically, the classification of madness evolved from Emil Kraepelin's late 19th-century concept of dementia praecox, which grouped early-onset psychotic illnesses with a presumed deteriorating course, distinguishing them from the cyclical manic-depressive insanity. This binary approach influenced early 20th-century psychiatry but shifted toward spectrum models in the mid-20th century, recognizing continuums of symptoms and outcomes, as seen in Eugen Bleuler's broadening to "schizophrenia group" and later dimensional assessments in DSM-5 and ICD-11 that incorporate severity gradients and comorbidities. Diagnosis relies on standardized tools to ensure reliability, such as the Structured Clinical Interview for DSM-5 (SCID-5), a semi-structured interview that systematically probes symptoms against DSM criteria to confirm psychotic disorders through detailed questioning on delusions, hallucinations, and disorganized thinking. For "madness" interpreted as severe reality distortion, criteria across both systems require evidence of grossly disorganized or catatonic behavior, negative symptoms, or marked impairment in reality testing, often assessed via clinical observation and patient reports to rule out cultural or situational factors.

Causes and Biological Mechanisms

Madness, encompassing severe mental disorders such as schizophrenia and bipolar disorder, arises from a complex interplay of genetic, neurobiological, environmental, and psychological factors. Genetic predispositions play a central role, with twin studies indicating heritability estimates of around 80% for schizophrenia, derived from higher concordance rates of approximately 40-50% in monozygotic twins compared to dizygotic pairs. This heritability is supported by genome-wide association studies (GWAS) identifying multiple risk loci, such as those in the MHC region, which collectively explain a significant portion of variance in susceptibility. Family-based research further reinforces this, showing that first-degree relatives of affected individuals have a 10-fold increased risk. Psychological frameworks complement biological models; for example, the diathesis-stress model posits that genetic vulnerabilities interact with psychosocial stressors to trigger psychotic episodes, emphasizing the role of cognitive and environmental factors in symptom onset and maintenance. Neurobiological mechanisms involve dysregulation in key brain systems. The dopamine hypothesis posits that excessive dopaminergic activity in mesolimbic pathways contributes to psychotic symptoms in disorders like schizophrenia, evidenced by the efficacy of antipsychotic medications that block D2 receptors. Complementary findings from neuroimaging, including MRI scans, reveal structural abnormalities such as enlarged lateral ventricles and reduced gray matter volume in prefrontal and temporal regions among affected individuals. Functional imaging like PET further demonstrates hypofunction in the prefrontal cortex during cognitive tasks, linking these changes to impaired executive function. Environmental factors often interact with genetic vulnerabilities to trigger onset. Prenatal infections, for instance, have been associated with elevated schizophrenia risk; for example, data from the 1957 Asian influenza pandemic showed increased cases among offspring exposed in utero during the second trimester, with relative risks of about 1.7. Childhood trauma and adversity, including abuse or neglect, increase odds by 2-3 fold through mechanisms like altered stress response via the HPA axis. Substance abuse, particularly cannabis in adolescence, exacerbates risk in genetically susceptible individuals, with meta-analyses reporting odds ratios of 2.1 for heavy users developing psychosis.

Cultural and Social Dimensions

Representations in Art and Literature

Madness has long served as a potent motif in art and literature, often symbolizing the fragility of the human mind and critiquing societal norms. In William Shakespeare's King Lear (1606), the protagonist's descent into madness is portrayed not merely as a symptom of grief and betrayal but as a vehicle for profound insight and social commentary, revealing the absurdities of power and family dynamics. Lear's raving speeches on the heath, where he questions justice and authority, underscore how madness strips away pretenses, exposing underlying truths about human vulnerability. This depiction draws from Elizabethan views of melancholy as both affliction and inspiration, influencing later interpretations of mental turmoil as a catalyst for revelation. In Gothic literature, madness frequently embodies themes of isolation and the monstrous consequences of unchecked ambition. Mary Shelley's Frankenstein (1818) exemplifies this through Victor Frankenstein's obsessive pursuit of knowledge, which spirals into hallucinations and guilt-induced derangement, mirroring the creature's own existential alienation. The novel uses madness to explore the blurred boundaries between creator and creation, portraying it as a consequence of defying natural and social orders, thereby critiquing Enlightenment rationalism. Shelley's narrative influenced subsequent Gothic works by framing madness as a metaphor for societal rejection and the horrors of individualism. Twentieth-century literature and art further evolved these representations, often linking madness to personal and cultural disintegration. Sylvia Plath's semi-autobiographical novel The Bell Jar (1963) vividly captures the suffocating experience of depressive madness, depicting protagonist Esther Greenwood's mental breakdown as a response to patriarchal pressures and identity loss, symbolized by the titular bell jar's stifling enclosure. Plath's work highlights the gendered dimensions of mental illness, portraying recovery as a tentative reclaiming of agency amid societal expectations. In visual art, Salvador Dalí's surrealist paintings, such as The Persistence of Memory (1931) with its melting clocks, evoke mental dissolution through distorted time and reality, symbolizing the subconscious chaos akin to Freudian interpretations of madness. These surrealist elements reflect broader modernist anxieties about rationality's collapse in the face of war and existential dread. These artistic portrayals occasionally intersect with broader societal stigma, reinforcing or challenging perceptions of the mad as outcasts, yet they primarily function as narrative tools to probe deeper psychological and ethical questions.

Societal Stigma and Marginalization

Throughout history, individuals labeled as "mad" have faced profound societal stigma, often resulting in exclusion, discrimination, and marginalization that extend beyond clinical settings into everyday social interactions. This stigma manifests as prejudice and stereotypes that portray those with mental illnesses as dangerous, unpredictable, or morally deficient, leading to barriers in employment, housing, and social relationships. For instance, in the United States, surveys indicate that over 60% of respondents hold negative attitudes toward people with schizophrenia, associating them with violence despite evidence showing no higher risk than the general population. The deinstitutionalization movement, which gained momentum from the 1950s to the 1980s, exemplifies how well-intentioned policy shifts can exacerbate community-level stigma and marginalization. Driven by advances in psychotropic medications and a push for civil rights, this effort closed large psychiatric asylums and transitioned patients to community-based care; however, inadequate funding for support services led to widespread homelessness among the mentally ill. In the U.S., approximately 25% of the homeless population suffers from severe mental illness, a direct consequence of this shift, with many facing rejection from families and communities unwilling to accommodate perceived "madness." Media portrayals have further entrenched these stereotypes, often depicting the "mad" as violent or irrational figures, reinforcing public fears and discriminatory attitudes. Iconic examples include the film Psycho (1960), where the protagonist's mental instability is sensationalized as a source of homicidal rage, contributing to the pervasive "madman" trope that influences real-world perceptions. Such representations correlate with increased stigma, as studies show that exposure to violent media depictions of mental illness heightens public endorsement of coercive treatment and social distance. Globally, stigma varies by cultural context, with collectivist societies often exhibiting higher levels due to emphasis on family honor and social harmony, leading to greater shame and avoidance of mental health treatment compared to individualistic Western cultures. According to World Health Organization (WHO) reports, in low- and middle-income countries—many with collectivist orientations—up to 85% of individuals with severe mental disorders receive no care, largely due to stigma-induced reluctance to seek help and community ostracism. For example, in parts of Asia and Africa, families may hide affected members to avoid reputational damage, perpetuating cycles of marginalization. These patterns highlight how cultural norms amplify the social costs of madness, distinct from but occasionally echoed in artistic depictions of isolation.

Insanity in Law

The insanity defense in criminal law allows a defendant to avoid conviction for a crime by demonstrating that a mental disorder rendered them incapable of forming the requisite criminal intent or understanding the wrongfulness of their actions. This affirmative defense shifts the focus from the act itself to the perpetrator's mental state at the time of the offense, requiring the prosecution to prove sanity beyond a reasonable doubt in some jurisdictions. Originating in English common law, it balances public safety with recognition of mental illness as a mitigating factor, though successful pleas remain rare, succeeding in less than 1% of cases. The foundational standard for the insanity defense is the M'Naghten Rule, established by the House of Lords in 1843 following the trial of Daniel M'Naghten, who assassinated Prime Minister Robert Peel's secretary under the delusion that he was being persecuted by the Tory party. The rule requires proof that, due to a "disease of the mind," the defendant either did not know the nature and quality of their act or did not know that the act was wrong. This cognitive test emphasizes the defendant's awareness rather than control over their impulses, and it remains the basis for insanity pleas in England, Wales, and many U.S. states, including California and New York. Critics argue it overlooks volitional impairments, such as inability to resist urges, leading to its evolution in various jurisdictions. In the United States, a prominent variation is the American Law Institute (ALI) test, formulated in Section 4.01 of the Model Penal Code in 1962, which broadens the M'Naghten criteria to include both cognitive and volitional elements. Under the ALI standard, a defendant is not responsible if, as a result of mental disease or defect, they lacked substantial capacity either to appreciate the criminality of their conduct or to conform their conduct to the law. This "irresistible impulse" component addresses cases where defendants understand right from wrong but cannot control their actions, and it has been adopted by about half of U.S. states, including federal courts until modifications post-1980s. The test aims for a more comprehensive assessment of mental impairment, drawing on psychiatric insights to evaluate both knowledge and self-control. A notable application occurred in the case of Andrea Yates, who drowned her five children in 2001 while suffering from severe postpartum psychosis. In her 2006 retrial—after an initial 2002 conviction was overturned due to prosecutorial misconduct—Yates was acquitted by reason of insanity under Texas law, which incorporates elements of the ALI test. Expert testimony established that her delusions, including beliefs that she was saving her children from Satan, rendered her unable to understand the wrongfulness of her acts or conform to legal standards. The verdict highlighted the defense's role in addressing extreme mental illnesses like postpartum psychosis, though it sparked debates on maternal mental health and criminal accountability.

Rights and Institutionalization

The rights of individuals experiencing madness have evolved significantly, emphasizing protections against arbitrary institutionalization and promoting community-based living. A landmark international framework is the United Nations Convention on the Rights of Persons with Disabilities (CRPD), adopted in 2006, which mandates that states prioritize community integration for persons with disabilities, including those with psychosocial disabilities related to madness, over institutionalization. Article 19 of the CRPD specifically requires governments to ensure that persons with disabilities have the opportunity to choose their place of residence and access community-based services, prohibiting forced institutionalization and fostering independent living with appropriate supports. This convention, ratified by 182 countries as of 2023, underscores the ethical imperative to treat madness not as grounds for isolation but as a condition warranting inclusion and autonomy. Historical abuses in institutions highlight the urgent need for such protections. In the United States, exposés of conditions in psychiatric facilities during the mid-20th century, such as those documented in reports on state mental hospitals, revealed widespread overcrowding, abuse, and neglect of individuals with mental illnesses. These revelations, including congressional investigations and media reports from the 1960s and 1970s, exposed systemic failures and accelerated the deinstitutionalization movement, influencing reforms that prioritized human rights over custodial confinement. Modern legal reforms in the U.S. have enshrined principles of the least restrictive environment, prohibiting indefinite institutionalization of non-dangerous individuals. The 1975 Supreme Court decision in O'Connor v. Donaldson ruled that a state cannot constitutionally confine a person with mental illness who is capable of surviving safely in the community, even if they reject treatment, affirming that freedom from unnecessary restraint is a fundamental right. This precedent, building on earlier civil rights advocacy, requires that any involuntary commitment be justified by imminent danger to self or others and limited in duration, with courts mandating alternatives like outpatient care. These protections extend briefly to intersect with criminal law defenses, ensuring that institutionalization does not override due process in legal proceedings. Ongoing enforcement through oversight bodies continues to challenge coercive practices, promoting ethical standards that view individuals with madness as rights-holders rather than wards of the state.

Treatment and Contemporary Approaches

Historical Therapies

In ancient humoral medicine, pioneered by the Greek physician Galen (c. 129–200 CE), madness was attributed to imbalances among the four bodily humors—blood, phlegm, yellow bile, and black bile—which could generate toxic vapors affecting the brain and leading to mental disturbances like melancholy or frenzy. Treatments focused on restoring equilibrium through evacuation methods, including bloodletting (phlebotomy), which involved drawing blood from veins near the affected area, such as the jugular for brain-related issues, to remove excess hot or corrupted blood believed to cause inflammation and irrationality. Purging, using emetics or laxatives, complemented this by expelling surplus humors, particularly black bile associated with despondency or mania, as Galen prescribed these interventions to cool overheated blood and prevent vapors from ascending to impair reason. These practices, dominant through the medieval and Renaissance periods, were applied broadly to mental illnesses without empirical validation, often exacerbating patient suffering through repeated procedures. Prehistoric evidence suggests even earlier invasive approaches, with trephining—drilling or scraping holes into the skull—serving as a precursor to later surgical interventions for mental disorders. Archaeological findings, including over 40 trepanned skulls from 6500 BCE in France and similar specimens across Europe, Peru, and the Near East, indicate this procedure was performed on living individuals, likely to release evil spirits thought to cause insanity or to relieve intracranial pressure from perceived supernatural afflictions. Survival rates, evidenced by bone regrowth around the holes in up to 90% of cases, imply a ritualistic or therapeutic intent rather than mere postmortem modification, though interpretations remain speculative based on the absence of written records. This method persisted into historical eras, influencing later ideas of physical intervention for madness, but carried high risks of infection and death. A shift toward humane alternatives emerged in the late 18th century with the moral treatment pioneered at the York Retreat, founded in 1796 by Quaker reformer William Tuke in response to the abusive conditions in traditional asylums. Unlike coercive methods, this approach emphasized kindness, respect for patients' innate rationality, and a structured environment fostering routine, occupation, and social interaction to restore mental order without physical restraints or isolation. Key principles, rooted in Enlightenment ideals and Quaker beliefs in the "inner light" of humanity, treated madness as a temporary disorder of reason amenable to gentle persuasion rather than punishment, achieving notable success in patient recovery through domestic-like settings and minimal medical intervention. The Retreat's model influenced global asylum reforms, prioritizing psychological comfort over bodily manipulation. By the Victorian era (1837–1901), hydrotherapy became a staple in asylums, employing water manipulations to soothe agitation and purportedly decongest the "overheated" brain underlying madness. Methods included prolonged warm baths lasting hours or days to calm violent patients, cold douches directing icy streams onto the head to shock the system into rationality, and wet-sheet wrappings that induced sweating to eliminate toxins. Devices like Alexander Morison's 19th-century douche apparatus restrained patients under cascading water, blending therapeutic intent with control, as physicians monitored vital signs to claim physiological benefits. Though non-invasive compared to trephining, these often punitive practices reflected persistent humoral influences but declined by the early 20th century in favor of emerging evidence-based therapies.

Non-Western Historical Approaches

In non-Western traditions, treatments for madness also emphasized balance and spiritual elements. In ancient Chinese medicine, as described in texts like the Huangdi Neijing (c. 200 BCE), mental disturbances were linked to imbalances in qi and the "heart-mind" (xin), treated through acupuncture, herbal remedies (e.g., ginseng for calming agitation), and dietary adjustments to harmonize yin-yang forces, influencing practices persisting into modern integrative care. Similarly, in Islamic medicine, physician Avicenna (Ibn Sina, 980–1037 CE) in his Canon of Medicine advocated pharmacological interventions like sedatives and purgatives derived from Greco-Arabic humoral theory, alongside music therapy and environmental changes to soothe the soul, reflecting a blend of rational and holistic methods applied across medieval caliphates.

Modern Interventions and Recovery

Modern interventions for madness, particularly in the context of psychotic disorders, have shifted toward evidence-based pharmacological, psychotherapeutic, and community-based approaches that prioritize symptom management, functional improvement, and personal empowerment. These methods emerged prominently after the mid-20th century, building on earlier pharmacological breakthroughs to offer more humane and effective recovery pathways. Antipsychotic medications represent a cornerstone of treatment, with chlorpromazine, synthesized in 1951 and introduced clinically in 1952 by researchers at Rhône-Poulenc including Paul Charpentier, marking the first major antipsychotic. This phenothiazine derivative revolutionized care by effectively controlling agitation and psychotic symptoms, leading to its widespread adoption globally by the mid-1950s. Its primary mechanism involves blockade of dopamine D2 receptors in the brain, which reduces positive symptoms such as hallucinations and delusions by modulating dopaminergic hyperactivity in mesolimbic pathways, as confirmed through receptor binding studies in the 1970s. Subsequent typical antipsychotics like haloperidol followed similar mechanisms, while atypical agents such as clozapine introduced additional serotonin receptor modulation for broader efficacy with fewer extrapyramidal side effects. These medications achieve symptom reduction in a majority of patients, with response rates varying by subtype (e.g., over 80% in some forms of schizophrenia) and overall efficacy supported by clinical trials, though long-term adherence remains a challenge due to side effects like weight gain and sedation. Psychotherapeutic interventions complement pharmacotherapy by addressing cognitive and emotional aspects of psychosis. Cognitive Behavioral Therapy for psychosis (CBTp), developed in the 1990s and supported by over 30 years of research, is a structured, time-limited approach that helps individuals manage distress from hallucinations and delusions through techniques like belief reevaluation, behavioral experiments, and relapse prevention. Meta-analyses of randomized controlled trials demonstrate that CBTp, when added to standard care, significantly reduces positive and negative symptoms, with effect sizes ranging from moderate to large, and improves quality of life measures such as emotional well-being and social functioning. For instance, in clozapine-resistant schizophrenia, CBTp outperforms treatment as usual at 9- and 21-month follow-ups, yielding net gains in quality-adjusted life years. Recovery-oriented models further emphasize a strengths-based perspective, shifting focus from symptom deficits to personal capabilities and aspirations. Recovery-Oriented Cognitive Therapy (CT-R), an extension of CBTp rooted in Aaron Beck's cognitive model, activates adaptive modes—positive beliefs and behaviors associated with an individual's best self—to foster motivation, social engagement, and goal pursuit in the face of psychosis. Unlike traditional CBTp's symptom-centric approach, CT-R prioritizes empowerment and resiliency, helping individuals with persistent negative symptoms or treatment resistance to overcome defeatist beliefs (e.g., "I am incapable") through shared activities and aspiration-building, as evidenced by randomized trials showing sustained improvements in community participation and positive symptoms at 6 months. These models align with broader mental health recovery principles, promoting hope and self-determination regardless of illness chronicity. Community support systems enhance recovery by integrating individuals into society through practical and relational aids. Supported employment programs, such as Individual Placement and Support (IPS), provide rapid job placement and ongoing coaching tailored to severe mental illness, achieving competitive employment rates of up to 82% among young adults with psychosis, compared to 42% in standard vocational services, with participants working an average of 25 weeks over 18 months. Peer support groups, facilitated by individuals with lived experience, offer mutual encouragement and stigma reduction, with systematic reviews indicating modest improvements in social functioning and hope, though effects on core symptoms vary. Early intervention programs incorporating these elements yield functional recovery rates of approximately 38-50% in first-episode psychosis cohorts, defined by sustained symptom remission, independent living, and occupational engagement, as reported in long-term meta-analyses and trials. Overall, these interventions promote holistic recovery, with integrated care models demonstrating reduced hospitalizations and enhanced quality of life.

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