Ames received formal artistic training at the School of the Museum of Fine Arts, Boston, and Smith College. She developed skills in painting, drawing, and illustration.

Ames produced a wide range of artwork, including portraits, landscapes, botanical illustrations, political cartoons, and illustrations for books and articles. She often used her art to promote her political and social beliefs.

Ames created numerous cartoons and posters advocating for women's suffrage. Her artwork helped to raise awareness of the cause and to persuade public opinion.

Ames continued to create art throughout her life, exploring a variety of subjects and styles. Her artistic legacy reflects her diverse interests and her commitment to social justice.