Blanche Ames engaged in writing projects throughout her life. Early on, this included journaling, poetry and short story work.

Blanche dedicated a significant part of her life to writing the biography of her father, Adelbert Ames, entitled "Adelbert Ames, 1835-1933". She wanted to defend his life against the false accusations.

After years of research and writing, Blanche Ames' biography of her father, Adelbert Ames, was published in 1964. The book provided a detailed account of his life and career and defended him against false accusations.

Ames' literary contributions, including her biography of her father, have helped to preserve his legacy and to provide insights into the political and social issues of his time. Her works continue to be studied by historians and scholars.