Blanche Ames married Oakes Ames, a Harvard University professor of botany and orchid expert. Their marriage connected her to the world of scientific research and intellectual pursuits.

Blanche and Oakes Ames established their home in North Easton, Massachusetts. Blanche took on the responsibilities of managing the household and raising their children, while also pursuing her artistic interests when possible.

Blanche and Oakes Ames had four children: Pauline, Evelyn, Oliver, and Amyas. Balancing motherhood with her artistic and intellectual pursuits presented considerable challenges.

During World War I, Blanche Ames contributed to the war effort through various activities, including volunteer work and fundraising. She also used her artistic skills to create posters and illustrations promoting patriotism and support for the troops.