Blanche had a close relationship with her parents, Adelbert and Blanche Butler Ames. Her mother fostered her artistic interests and encouraged her independence, while her father provided her with a strong sense of social justice.

Blanche's marriage to Oakes Ames was a significant part of her life. Their marriage was a partnership of intellectual engagement and mutual support, despite the challenges of balancing family and professional pursuits. He died in 1955. Their relationship was based on mutual respect for one another's individual pursuits and passions.

Blanche was a devoted mother to her four children: Pauline, Evelyn, Oliver, and Amyas. She instilled in them a love of learning, a commitment to social justice, and a strong sense of independence.

In her later years, Blanche enjoyed spending time with her grandchildren, sharing her stories and experiences with them. She remained a source of inspiration and support for her family.