Blanche Ames became actively involved in the women's suffrage movement, recognizing the need for women to have the right to vote. She joined the Massachusetts Woman Suffrage Association and other suffrage organizations.

Ames employed her artistic talents to create powerful posters, illustrations, and cartoons advocating for women's suffrage. Her artwork helped to raise awareness of the cause and to persuade public opinion.

Ames served as president of the Massachusetts Woman Suffrage Association, providing leadership and direction to the organization's efforts to secure voting rights for women in the state.

With the ratification of the 19th Amendment to the U.S. Constitution, granting women the right to vote, Ames celebrated the culmination of years of hard work and dedication to the suffrage cause. She continued to advocate for women's rights in other areas.