"Coma White" is a song by American rock band Marilyn Manson and the last track on the album Mechanical Animals. It is a hard rock ballad written by Manson, Twiggy Ramirez, Madonna Wayne Gacy, Zim Zum and produced by Manson and Michael Beinhorn. It was inspired by Manson's relationship with Rose McGowan and the numbness that his drug use caused him to feel. The track features a snare drum, cymbals, guitar, piano and keyboard bass in its instrumentation. Critics offered varied interpretations of its meaning, ranging from a song about a drug-addicted woman to a critique of celebrity culture. The song garnered a mostly positive response from music critics, with some critics deeming it one of the greatest songs of the band's career.

The song's music video was directed by Samuel Bayer. It recreates the assassination of John F. Kennedy with Manson as President Kennedy, McGowan as Jacqueline Kennedy, and the other members of the band as Secret Service agents; it also features Manson on a cross. Manson explained that it was intended as a tribute to men like Kennedy and Jesus who "died at the hands of mankind's unquenchable thirst for violence." It garnered significant controversy, and its premiere on MTV was delayed due to both the Columbine High School massacre and the death of John F. Kennedy Jr. Critical response to the clip was mixed; some critics found it touching while others felt it was unsuited to the song.

After the release of Antichrist Superstar (1996), an album which sparked controversy among Christian fundamentalists, Marilyn Manson didn't want to resume playing the role of a bogeyman. He feared that this would cause him to be "consigned to the one-note rock theatricality" of Kiss and Alice Cooper. He desired to convince casual rock and pop fans who had previously dismissed him that he was "more than a cartoon". For his next album, Mechanical Animals (1998), he took inspiration from the glam rock music that David Bowie made in the 1970s, and adopted a wardrobe and hairstyle similar to Bowie's.

Discussing Mechanical Animals with Lorraine Ali, Manson said: "There is a bit of a love story that exists on this record. The name I gave to the thing I was in love with was Coma White. It starts as the name of a girl I'm in love with, then ends up to really be a drug I've been taking. So I'm not really sure what I'm in love with." In 1999, Manson said that the song "Coma White" was inspired by his relationship with Rose McGowan, elaborating: "A lot of the pain she's gone through, I started to feel, and the record kind of documents me coming to terms with emotions and caring about somebody for the first time. And I guess I still express the fear of doing that as well."

Manson was asked about the use of the word "white" in the song's title in a 2017 interview with Consequence of Sound. He replied: "A lot of people thought that it was a race thing, and it was more of the idea that white is the composition of all colors." Manson has also said that "The color white comes up a lot. It kind of represents to me the numbness that I had. The numbness is manifested in drugs...in all the people who want to suck the life out of you when you become a rock star."

"Coma White" is a hard rock ballad that features elements of heavy metal music. It was written by Madonna Wayne Gacy, Marilyn Manson, Twiggy Ramirez and Zim Zum, and produced by Manson and Michael Beinhorn. Its instrumentation features a snare drum, cymbals, guitar, piano, mellotron and keyboard bass. It serves as the final song on Mechanical Animals. Chad Childers of Noisecreep described the song as one of the album's "more stripped back efforts". Manson does not scream in "Coma White" and other songs from Mechanical Animals as he did in some of his earlier work. Rather, according to Entertainment Weekly's David Browne, he apes the vocal stylings of Marc Bolan and David Bowie.

Ramirez plays the song's guitar solos. Stereogum's Joseph Schafer found the lead guitar riff of "Coma White" "cruel, frigid, and glitchy" and similar to Adrian Belew's work for Trent Reznor. Schafer felt that the drums in the song sound like the collaborations between Robert John "Mutt" Lange and Def Leppard on the album Hysteria (1987). He also wrote that the tracks' "snare and cymbals seem a bit damp, ringing and warbling just intermittently enough to suggest the laws of audio physics fraying at the edges." The song has the chorus "A pill to make you numb/ A pill to make you dumb/ A pill to make you anybody else/ But all the drugs in this world/ won't save her from herself." Manson puts pauses before the words "numb" and "dumb" in the chorus which are reminiscent of Pinter pauses. The track has a "sibling" song from Holy Wood (In the Shadow of the Valley of Death) (2000) entitled "Coma Black", which is also a ballad.

Critics offered different interpretations of the song's meaning. The Globe and Mail's Robert Everett-Green called it a "song about a druggy doomed woman". According to Ann Powers of Rolling Stone, the song, like several tracks on Mechanical Animals, focuses on a person's final moments before death and suggests themes of betrayal. Bob Waliszewski of PluggedIn deemed "Coma White" anti-drug and contrasted it with other songs on the album like "I Don't Like the Drugs (But the Drugs Like Me)" and "The Dope Show" which he felt glamorized drug use. Schafer wrote that "Coma White" displays "all of Manson's favorite themes — the seductive evil of prescription medication, lost love, [and] the paralyzing effect of celebrity culture". Craig Hlavaty wrote in the Houston Press that the song is about the assassination of John F. Kennedy.