Earth system science (ESS) is the application of systems science to the Earth. In particular, it considers interactions and 'feedbacks', through material and energy fluxes, between the Earth's sub-systems' cycles, processes and "spheres"—atmosphere, hydrosphere, cryosphere, geosphere, pedosphere, lithosphere, biosphere, and even the magnetosphere—as well as the impact of human societies on these components. At its broadest scale, Earth system science brings together researchers across both the natural and social sciences, from fields including ecology, economics, geography, geology, glaciology, meteorology, oceanography, climatology, paleontology, sociology, and space science. Like the broader subject of systems science, Earth system science assumes a holistic view of the dynamic interaction between the Earth's spheres and their many constituent subsystems fluxes and processes, the resulting spatial organization and time evolution of these systems, and their variability, stability and instability. Subsets of Earth System science include systems geology and systems ecology, and many aspects of Earth System science are fundamental to the subjects of physical geography and climate science.

The Science Education Resource Center, Carleton College, offers the following description: "Earth System science embraces chemistry, physics, biology, mathematics and applied sciences in transcending disciplinary boundaries to treat the Earth as an integrated system. It seeks a deeper understanding of the physical, chemical, biological and human interactions that determine the past, current and future states of the Earth. Earth System science provides a physical basis for understanding the world in which we live and upon which humankind seeks to achieve sustainability".

Earth System science has articulated four overarching, definitive and critically important features of the Earth System, which include:

For millennia, humans have speculated how the physical and living elements on the surface of the Earth combine, with gods and goddesses frequently posited to embody specific elements. The notion that the Earth, itself, is alive was a regular theme of Greek philosophy and religion.

Early scientific interpretations of the Earth system began in the field of geology, initially in the Middle East and China, and largely focused on aspects such as the age of the Earth and the large-scale processes involved in mountain and ocean formation. As geology developed as a science, understanding of the interplay of different facets of the Earth system increased, leading to the inclusion of factors such as the Earth's interior, planetary geology, living systems and Earth-like worlds.

In many respects, the foundational concepts of Earth System science can be seen in the natural philosophy 19th century geographer Alexander von Humboldt. In the 20th century, Vladimir Vernadsky (1863–1945) saw the functioning of the biosphere as a geological force generating a dynamic disequilibrium, which in turn promoted the diversity of life.

In parallel, the field of systems science was developing across numerous other scientific fields, driven in part by the increasing availability and power of computers, and leading to the development of climate models that began to allow the detailed and interacting simulations of the Earth's weather and climate. Subsequent extension of these models has led to the development of "Earth system models" (ESMs) that include facets such as the cryosphere and the biosphere.

In 1983 a NASA committee called the Earth System Science Committee was formed. The earliest reports of NASA's ESSC, Earth System Science: Overview (1986), and the book-length Earth System Science: A Closer View (1988), constitute a major landmark in the formal development of Earth system science. Early works discussing Earth system science, like these NASA reports, generally emphasized the increasing human impacts on the Earth system as a primary driver for the need of greater integration among the life and geo-sciences, making the origins of Earth system science parallel to the beginnings of global change studies and programs.