Enrico Fermi (Italian: [enˈriːko ˈfermi]; 29 September 1901 – 28 November 1954) was an Italian and naturalized American physicist, renowned for being the creator of the world's first artificial nuclear reactor, the Chicago Pile-1, and a member of the Manhattan Project. He has been called the "architect of the nuclear age" and the "architect of the atomic bomb". He was one of very few physicists to excel in both theoretical and experimental physics. Fermi was awarded the 1938 Nobel Prize in Physics for his work on induced radioactivity by neutron bombardment and for the discovery of transuranium elements. With his colleagues, Fermi filed several patents related to the use of nuclear power, all of which were taken over by the US government. He made significant contributions to the development of statistical mechanics, quantum theory, and nuclear and particle physics.

Fermi's first major contribution involved the field of statistical mechanics. After Wolfgang Pauli formulated his exclusion principle in 1925, Fermi followed with a paper in which he applied the principle to an ideal gas, employing a statistical formulation now known as Fermi–Dirac statistics. Today, particles that obey the exclusion principle are called "fermions". Pauli later postulated the existence of an uncharged invisible particle emitted along with an electron during beta decay, to satisfy the law of conservation of energy. Fermi took up this idea, developing a model that incorporated the postulated particle, which he named the "neutrino". His theory, later referred to as Fermi's interaction and now called weak interaction, described one of the four fundamental interactions in nature. Through experiments inducing radioactivity with the recently discovered neutron, Fermi discovered that slow neutrons were more easily captured by atomic nuclei than fast ones, and he developed the Fermi age equation to describe this. After bombarding thorium and uranium with slow neutrons, he concluded that he had created new elements. Although he was awarded the Nobel Prize for this discovery, the new elements were later revealed to be nuclear fission products.

Fermi left Italy in 1938 to escape new Italian racial laws that affected his Jewish wife, Laura Capon. He emigrated to the United States, where he worked on the Manhattan Project during World War II. Fermi led the team at the University of Chicago that designed and built Chicago Pile-1, which went critical on 2 December 1942, demonstrating the first human-created, self-sustaining nuclear chain reaction. He was on hand when the X-10 Graphite Reactor at Oak Ridge, Tennessee, went critical in 1943, and when the B Reactor at the Hanford Site did so the next year. At Los Alamos, he headed F Division, part of which worked on Edward Teller's thermonuclear "Super" bomb. He was present at the Trinity test on 16 July 1945, the first test of a full nuclear bomb explosion, where he used his Fermi method to estimate the bomb's yield.

After the war, he helped establish the Institute for Nuclear Studies in Chicago, and served on the General Advisory Committee, chaired by J. Robert Oppenheimer, which advised the Atomic Energy Commission on nuclear matters. After the detonation of the first Soviet fission bomb in August 1949, he strongly opposed the development of a hydrogen bomb on both moral and technical grounds. He was among the scientists who testified on Oppenheimer's behalf at the 1954 hearing that resulted in the denial of Oppenheimer's security clearance.

Fermi did important work in particle physics, especially related to pions and muons, and he speculated that cosmic rays arose when the material was accelerated by magnetic fields in interstellar space. Many awards, concepts, and institutions are named after Fermi, including the Fermi 1 (breeder reactor), the Enrico Fermi Nuclear Generating Station, the Enrico Fermi Award, the Enrico Fermi Institute, the Fermi National Accelerator Laboratory (Fermilab), the Fermi Gamma-ray Space Telescope, the Fermi paradox, and the synthetic element fermium, making him one of 16 scientists who have elements named after them.

Enrico Fermi was born in Rome, Italy, on 29 September 1901. He was the third child of Alberto Fermi, a division head in the Ministry of Railways, and Ida de Gattis, an elementary school teacher. His sister, Maria, was two years older, his brother Giulio a year older. After the two boys were sent to a rural community to be wet nursed, Enrico rejoined his family in Rome when he was two and a half. Although he was baptized a Catholic in accordance with his grandparents' wishes, his family was not particularly religious; Enrico was an agnostic throughout his adult life. As a young boy, he shared the same interests as his brother Giulio, building electric motors and playing with electrical and mechanical toys. Giulio died during an operation on a throat abscess in 1915 and Maria died in an airplane crash near Milan in 1959.

At a local market in Campo de' Fiori, Fermi found a physics book, the 900-page Elementorum physicae mathematicae. Written in Latin by Jesuit Father Andrea Caraffa [it], a professor at the Collegio Romano, it presented mathematics, classical mechanics, astronomy, optics, and acoustics as they were understood at the time of its 1840 publication. With a scientifically inclined friend, Enrico Persico, Fermi pursued projects such as building gyroscopes and measuring the acceleration of Earth's gravity.

Enrico would often meet his father Alberto in front of his office after work, and in 1914 he met his father’s colleague Adolfo Amidei, who was accustomed to walking part of the way home with Alberto.