Haplogroup O-M122
Haplogroup O-M122
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Haplogroup O-M122

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Haplogroup O-M122

Haplogroup O-M122 (also known as Haplogroup O2 (formerly Haplogroup O3)) is an Eastern Eurasian Y-chromosome haplogroup. The lineage ranges across Southeast Asia and East Asia, where it dominates the paternal lineages with extremely high frequencies. Certain subclades also have a significant presence in Central Asia, South Asia (e.g. Nepal, Northeast India), and Oceania.

This lineage is a descendant haplogroup of haplogroup O-M175.

Researchers believe that O-M122 first appeared in Southeast Asia approximately 25,000-30,000 years ago, or roughly between 30,000 and 35,000 years ago according to more recent studies. In a systematic sampling and genetic screening of an East Asian–specific Y-chromosome haplogroup (O-M122) in 2,332 individuals from diverse East Asian populations, results indicate that the O-M122 lineage is dominant in East Asian populations, with an average frequency of 44.3%. Microsatellite data show that the O-M122 haplotypes are more diverse in Southeast Asia than those in northern East Asia. This suggests a southern origin of the O-M122 mutation to be likely.

It was part of the settlement of East Asia. However, the prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations and the place of the O-M122 lineage in these migrations is ambivalent.[citation needed]

Haplogroup O-M122 is found in approximately 53.35% of all modern Chinese males (with frequency ranging from 30/101=29.7% among Pinghua-speaking Hans in Guangxi to 110/148=74.3% among Hans in Changting, Fujian ), about 40% of Manchu, Chinese Mongolian, Korean, and about 33.3% of Filipino males, Vietnamese males, about 10.5% to 55.6% of Malaysian males, about 10% (4/39 Guide County, Qinghai) to 45% (22/49 Zhongdian County, Yunnan) of Tibetan males, about 20% (10/50 Shuangbai, northern Yunnan) to 44% (8/18 Xishuangbanna, southern Yunnan) of Yi males, about 25% of Zhuang and Indonesian males, and about 16% to 20% of Japanese males. The distribution of Haplogroup O-M122 stretches far into Asia (approx. 40% of Dungans, 30% of Salars, 28% of Bonan, 24% of Dongxiang, 18% to 22.8% of Mongolian citizens in Ulaanbaatar, 11%-15.4% of Khalkha Mongolians, but also as high as 31.1%, 12% of Uyghurs, 9% of Kazakhs, but in the Naiman of Kazakhs 65.81%, 6.8% of Kalmyks (17.1% of Khoshuud, 6.1% of Dörwöd, 3.3% of Torguud, 0% of Buzawa), 6.2% of Altaians, 5.3% of Kyrgyz, about 5.2% of Uzbeks (2.4% of Uzbeks in Afghanistan, 4.1% of Uzbeks in Uzbekistan, 4.3% of Uzbeks in Xinjiang, 5.1% of Uzbeks in Xorazm Region of Uzbekistan, 5.8% of Uzbeks in the Tashkent area of Uzbekistan, 11.9% of Uzbeks in Fergana Region of Uzbekistan, 20% of Uzbeks in Turkistan Region of Kazakhstan) and 4.0% of Buryats.

Modern northern Han Chinese Y haplogroups and mtdna match those of ancient northern Han Chinese ancestors 3,000 years ago from the Hengbei archeological site. 89 ancient samples were taken. Y haplogroups O3a, O3a3, M, O2a, Q1a1, and O* were all found in Hengbei samples. Three men who lived in the Neolithic era are the ancestors of 40% of Han Chinese, with their Y haplogroups being subclades of O3a-M324 and they are estimated to have lived 6,800 years ago, 6,500 years ago and 5,400 years ago.

The East Asian O3-M122 Y chromosome Haplogroup is found in large quantities in other Muslims close to the Hui people like Dongxiang, Bo'an and Salar. The majority of Tibeto-Burmans, Han Chinese, and Ningxia and Liaoning Hui share paternal Y chromosomes of East Asian origin which are unrelated to Middle Easterners and Europeans. In contrast to distant Middle Eastern and Europeans whom the Muslims of China are not related to, East Asians, Han Chinese, and most of the Hui and Dongxiang of Linxia share more genes with each other. This indicates that native East Asian populations converted to Islam and were culturally assimilated to these ethnicities and that Chinese Muslim populations are mostly not descendants of foreigners as claimed by some accounts while only a small minority of them are.

Haplogroup O2-M122 is primarily found among the males of Tibeto-Burmese ancestry in the Himalayas and Northeast India. In Arunachal Pradesh, it is found at 89% among Adi, 82% among Apatani, and 94% among Nishi, while the Naga people show it at 100%. In Meghalaya, 59.2% (42/71) of a sample of Garos and 31.7% (112/353) of a sample of Khasis have been found to belong to O-M122. In Nepal, Tamang people present a very high frequency of O-M122 (39/45 = 86.7%), while much lower percentages of Newar (14/66 = 21.2%) and the general population of Kathmandu (16/77 = 20.8%) belong to this haplogroup. A study published in 2009 found O-M122 in 52.6% (30/57, including 28 members of O-M117 and two members of O-M134(xM117)) of a sample of Tharus from a village in Chitwan District of south-central Nepal, 28.6% (22/77, all O-M117) of a sample of Tharus from another village in Chitwan District, and 18.9% (7/37, all O-M117) of a sample of Tharus from a village in Morang District of southeastern Nepal. In contrast, the same study found O-M122 in only one individual in a sample of non-Tharu Hindus collected in Chitwan District (1/26 = 3.8% O-M134(xM117)), one tribal individual from Andhra Pradesh, India (1/29 = 3.4% O-M117), and one individual in a sample of Hindus from New Delhi, India (1/49 = 2.0% O-M122(xM134)).

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