Hydrodesulfurization (HDS), also called hydrotreatment or hydrotreating, is a catalytic chemical process widely used to remove sulfur (S) from natural gas and from refined petroleum products, such as gasoline or petrol, jet fuel, kerosene, diesel fuel, and fuel oils. The purpose of removing the sulfur, and creating products such as ultra-low-sulfur diesel, is to reduce the sulfur dioxide (SO₂) emissions that result from using those fuels in automotive vehicles, aircraft, railroad locomotives, ships, gas or oil burning power plants, residential and industrial furnaces, and other forms of fuel combustion.

Another important reason for removing sulfur from the naphtha streams within a petroleum refinery is that sulfur, even in extremely low concentrations, poisons the noble metal catalysts (platinum and rhenium) in the catalytic reforming units that are subsequently used to upgrade the octane rating of the naphtha streams.

The industrial hydrodesulfurization processes include facilities for the capture and removal of the resulting hydrogen sulfide (H₂S) gas. In petroleum refineries, the hydrogen sulfide gas is then subsequently converted into byproduct, sulfur (S) or sulfuric acid (H₂SO₄). In fact, the vast majority of the 64,000,000 metric tons of sulfur produced worldwide in 2005 was byproduct sulfur from refineries and other hydrocarbon processing plants.

An HDS unit in the petroleum refining industry is also often referred to as a hydrotreater and is the most common of the processing units found in a modern refinery. There are more than 1600 active hydrotreating units across more than 600 refineries globally with a combined capacity in excess of 400 million barrels per day (including all forms of hydrotreating but excluding hydrocracking and reforming processes).

Although some reactions involving catalytic hydrogenation of organic substances were already known, the property of finely divided nickel to catalyze the fixation of hydrogen on hydrocarbon (ethylene, benzene) double bonds was discovered by the French chemist Paul Sabatier in 1897. Through this work, he found that unsaturated hydrocarbons in the vapor phase could be converted into saturated hydrocarbons by using hydrogen and a catalytic metal, laying the foundation of the modern catalytic hydrogenation process.

Soon after Sabatier's work, a German chemist, Wilhelm Normann, found that catalytic hydrogenation could be used to convert unsaturated fatty acids or glycerides in the liquid phase into saturated ones. He was awarded a patent in Germany in 1902 and in Britain in 1903, which was the beginning of what is now a worldwide industry.

In the mid-1950s, the first noble metal catalytic reforming process (the Platformer process) was commercialized. At the same time, the catalytic hydrodesulfurization of the naphtha feed to such reformers was also commercialized. In the decades that followed, various proprietary catalytic hydrodesulfurization processes, such as the one depicted in the flow diagram below, have been commercialized. Currently, virtually all of the petroleum refineries worldwide have one or more HDS units.

By 2006, miniature microfluidic HDS units had been implemented for treating JP-8 jet fuel to produce clean feed stock for a fuel cell hydrogen reformer. By 2007, this had been integrated into an operating 5 kW fuel cell generation system.