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| Infralimbic cortex | |
|---|---|
| Details | |
| Identifiers | |
| Latin | Cortex infralimbicus |
| Anatomical terms of neuroanatomy | |
The infralimbic cortex (IL) is a cortical region in the ventromedial prefrontal cortex which is important in tonic inhibition of subcortical structures and emotional responses, such as fear.[1]
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GABAergic neurons within the amygdala, known as intercalated (ITC) cells, receive a strong projection from the IL medial prefrontal cortex (mPFC) in primates.[2] ITC cells are thought to play a role as the 'off switch' for the amygdala, inhibiting the amygdala's central nucleus output neurons and its basolateral nucleus neurons.[3] Further, it has been shown that electrical stimulation of IL reduces conditioned fear and strengthens extinction memory[clarification needed], explaining cortical control over extinction processes,[clarification needed] one of the simplest forms of emotional regulation.[3]
Amygdala ITC cells receive strong projection from the IL mPFC in rodents as well.[4]
