Kenneth Dale Holtzman (November 3, 1945 – April 15, 2024) was an American professional baseball player and coach. He was a left-handed pitcher in Major League Baseball from 1965 through 1979 for the Chicago Cubs, Oakland Athletics, Baltimore Orioles, and New York Yankees.

With the Cubs, Holtzman pitched two no-hitters. He played for the Athletics' dynasty that won three consecutive World Series championships between 1972 and 1974. A two-time All-Star, Holtzman was a 20-game-winner for the Athletics in 1973. He is a member of the Chicago Cubs Hall of Fame.

Holtzman was born in St. Louis, Missouri, on November 3, 1945, to Henry and Jacqueline Holtzman. He was raised in an observant Jewish family and graduated from University City High School in St. Louis in 1963. He attended the University of Illinois Urbana-Champaign, where he played college baseball for the Illinois Fighting Illini. He graduated with a Bachelor of Arts in business administration and French.

The Chicago Cubs selected Holtzman in the fourth round of the 1965 Major League Baseball draft. At age 19, Holtzman pitched 12 games in the minor leagues in 1965, four with the Treasure Valley Cubs in the Pioneer League, and eight with the Wenatchee Chiefs in the Northwest League. He was 8–3 in the dozen starts, with a 1.99 earned run average and 114 strikeouts in 86 innings.

The Cubs promoted Holtzman to the major leagues in September 1965. After making three relief appearances in 1965, Holtzman joined the Cubs' starting rotation in 1966, and had an 11–16 rookie campaign as the team finished in last place.

As a promising Jewish left-hander, he was heralded as "the new Sandy Koufax." He pitched against Koufax in 1966 on September 25, and took the win by a 2–1 score, becoming the last pitcher to beat Koufax during the regular season. Koufax would make his last regular-season appearance a week later, on October 2. Holtzman served in the National Guard in 1967 and was only available to play on weekends. He appeared in 12 games and had a 9–0 record. After going 11–14 in 1968, he posted consecutive 17-win seasons. Holtzman was named NL Player of the Month in May 1969 with a 6–0 record, a 2.16 ERA, and 44 strikeouts.

That August 19, Holtzman pitched a no-hitter at Wrigley Field against the eventual Western Division champion Atlanta Braves, winning 3–0 on Ron Santo's three-run home run and outdueling the Braves' Phil Niekro. Holtzman had no strikeouts and three walks in the game. This was the first no-hitter by a Cub left-hander at Wrigley Field and the third no-hitter ever thrown without a strikeout (Earl Hamilton on August 30, 1912; Sad Sam Jones on September 4, 1923), a feat that has not been equaled since. In the seventh inning, Hank Aaron crushed a drive to left field that appeared to be a home run, but the wind held up the ball, enabling Billy Williams to catch the long fly ball in the recessed "well" at the wall in left field. Holtzman faced Aaron again in the ninth, and got him to ground out to second base to complete the no-hitter. The Cubs led the Eastern Division for much of the season before finishing in second place, eight games behind the eventual world champion New York Mets.

In 1970, had a 17–11 record and a 3.38 ERA, and finished third in the NL in starts (38), fifth in both strikeouts (202) and innings pitched (287+2⁄3), sixth in complete games (15) and ninth in wins. Baseball historian Bill James considers the Cubs' 1970 rotation of Holtzman, Ferguson Jenkins, Milt Pappas, and Bill Hands was the best of the 1970s.