The canton of Lucerne (German: Kanton Luzern [ˈkantɔn luˈtsɛrn]; Romansh: Chantun Lucerna; French: Canton de Lucerne; Italian: Cantone Lucerna) is a canton of Switzerland. It is located in the country's central, German-speaking part. The population of the canton (as of 31 December 2020) is 416,347. As of 2007^[update], the population included 57,268 foreigners, or about 15.8% of the total population. The cantonal capital is the city of Lucerne.

The canton of Lucerne comprises territories acquired by its capital Lucerne, either by treaty, armed occupation or purchase. The first town acquired was Weggis (in 1380), Rothenburg, Kriens, Horw, Sempach and Hochdorf (all in 1394), Wolhusen and Entlebuch (1405), the so-called "Habsburger region" to the northeast of the town of Lucerne (1406), Willisau (1407), Sursee and Beromünster (1415), Malters (1477) and Littau (1481), while in 1803, in exchange for Hitzkirch, Merenschwand (held since 1397) was given up.

The oldest traces of humans in the Lucerne area are stone artifacts and cave bear bones found in the Steigelfadbalm cave on Mt. Rigi from the Middle Paleolithic or about 30,000 BC. Other animal bones including mammoth, reindeer and giant deer from the local glacial maximum have also been found in the canton. Around 17,000 BC the glaciers disappeared from the Swiss plateau and recolonization is likely at that time.

The first Paleolithic and Mesolithic settlement discovered in the canton is in the Wauwilermoos, which is now a Swiss heritage site of national significance. A number of other settlements have since been found, mainly on sandy, dry elevations in the immediate vicinity of water. The settlements of Egolzwil 3 in Wauwilermoos in Egolzwil, Seematte at Hitzkirch and Halbinsel in Sursee are part of the Prehistoric Pile dwellings around the Alps a UNESCO World Heritage Site.

The Wauwilermoos houses had wooden or bark floors and hearths of clay. The villages had ceramic vessels and wood, bone, antler, stone and flint tools as well as textiles. Copper ax blades and knives provide the first evidence of metal use in Switzerland. Imported mollusks show that there were trade connections to the Mediterranean. The bones at Egolzwil 3 are over two thirds from domestic animals with the remainder from wild animals. The main domesticated animals were sheep, goats and pigs with only a few domestic cattle. The animals hunted included deer, roe deer, wild boar and elk.

During the Bronze Age the canton was quite settled. There were a number of settlements on the shores of Lake Sempach and Lake Baldegg along with hilltop settlements, graves and scattered items throughout the area. At Hochdorf-Baldegg a fenced village from the early Bronze Age (2200–1500 BC) was uncovered. The single-story houses all had clay or stone hearths. During the Middle Bronze Age (1550–1350 BC) most of the villages were not located directly on the lake shores. The Late Bronze Age settlement at Sursee-Zellmoos on Lake Sempach featured houses arranged in rows with mortared stone. The walls were timber lined with clay. Another Late Bronze Age settlement near the village of Schötz was densely populated between 1350 and 800 BC.

While numerous individual Iron Age items have been found, almost no settlements have been discovered. From the Hallstatt period (800–480 BC) mainly graves have been discovered. Very little is known about the La Tène period (480–30 BC) in Lucerne. Some iron tools, gold coins, ceramic vessels and a glass bangle as well as a burial ground with at least four graves have been found.

During the Roman era, the canton was once again thickly settled. A number of farms were built in the north–south running valleys (Wigger, Suhre, Wyna and See valleys). During the 1st century AD, the farms provided food for the Legion camp in Vindonissa and for the larger settlements located in the Swiss plateau.