Manosque (French pronunciation: [manɔsk]; Provençal Occitan: Manòsca in classical norm or Manosco in Mistralian norm) is the largest town and commune in the Alpes-de-Haute-Provence department in southeastern France. However, it is not the préfecture (capital) of the department, which is the smaller town of Digne-les-Bains. Manosque is located at the far eastern end of the Luberon near the Durance river.

Manosque has existed since before 966 when it is first mentioned historically.^{[citation needed]} Commerce thrived in the town in the 13th century leading the population to increase to 10,000 inhabitants.^{[citation needed]} It was at this time that the city walls were constructed. They have been completely destroyed apart from a few remaining gates. The population suffered greatly starting in the 18th century due to plagues in 1720 and 1834.^{[citation needed]} Between 1950 and 1970, the town had a huge increase in population along with other areas south of the Luberon. A threefold increase in inhabitants occurred.

Manosque is twinned with: