Mark 6 is the sixth chapter of the Gospel of Mark in the New Testament of the Christian Bible. In this chapter, Jesus goes to Nazareth and experiences rejection by his own family. He then sends his Apostles in pairs to various cities in the region, where they might also face rejection. Finally, Jesus goes back to the Sea of Galilee and performs some of his most famous miracles, including the feeding of the 5,000 and walking on water. This chapter also gives an account of the murder of John the Baptist.

The original text was written in Koine Greek. This chapter is divided into 56 verses.

Some early manuscripts containing the text of this chapter are:

In 1972, Spanish papyrologist Jose O'Callaghan proposed in his work ¿Papiros neotestamentarios en la cueva 7 de Qumrân? ("New Testament Papyri in Cave 7 at Qumran?") that among the Dead Sea Scrolls, 7Q5, a small Greek papyrus fragment discovered in Qumran Cave 7 (dated between 50 B.C. and 50 A.D), actually contains the text from Mark 6:52–53, and this was later reasserted and expanded by German scholar Carsten Peter Thiede in his work The Earliest Gospel Manuscript? in 1982. Carlo Maria Martini, S.J., Archbishop of Milan and part of the five member team which edited the definitive modern edition of the Greek New Testament for the United Bible Societies, agreed with O'Callaghan's identification and assertions, but the majority of scholars have not been convinced by O'Callaghan's and Thiede's arguments.

Jesus leaves "from there" (i.e. Capernaum), and goes to his "home town" (Greek: τὴν πατρίδα αὐτοῦ, tēn patrida autou). Heinrich Meyer argues that "there" refers to Jairus' house, the last location mentioned in chapter 5, and John McEvilly concurs that this was likely to have been the case.

Nazareth is not named here explicitly, but Mark 1:9 states that "Jesus came from Nazareth of Galilee". It lies about 42 kilometres (26 mi) from Capernaum on modern roads.

Mark relates the story of Jesus' initial acclaim and later rejection at Nazareth, "his own country". The account is also found in Matthew 13:53–58 and it is related at an earlier point in Jesus' ministry in Luke 4:14–30. Verse 2 notes that "many who heard him" were impressed by the wisdom which had been given to him (or, "to such a man": manuscripts differ in the wording of this verse), and the "mighty works" performed by his hands. Since in verse 5, Mark goes on to note that Jesus performed a minimal amount of healing in Nazareth, it is generally supposed that they had heard of the miracles which Jesus had performed in Capernaum and elsewhere. His neighbours question his authority and do not seem to think much of the Jesus they remember or his family. "Isn't this the carpenter (τέκτων, tektōn)? Isn't this Mary's son and the brother of James, Joseph, Judas and Simon? Aren't his sisters here with us?"

Jesus replies with a proverb, Only in his hometown, among his relatives and in his own house is a prophet without honor. John 4:44 records the same sentiment: Jesus Himself testified that a prophet has no honor in his own country, but in John's account the Galileans received Him, having seen all the things He did in Jerusalem at the feast.