Skylab was the United States' first space station, launched by NASA, occupied for about 24 weeks between May 1973 and February 1974. It was operated by three trios of astronaut crews: Skylab 2, Skylab 3, and Skylab 4. Skylab was constructed from a repurposed Saturn V third stage (the S-IVB), and took the place of the stage during launch. Operations included an orbital workshop, a solar observatory, Earth observation and hundreds of experiments. Skylab's orbit eventually decayed and it disintegrated in the atmosphere on July 11, 1979, scattering debris across the Indian Ocean and Western Australia.

As of 2025,^[update] Skylab has been the only space station operated exclusively by the United States. A permanent station was planned starting in 1988, but its funding was canceled and U.S. participation shifted to the International Space Station in 1993.

Skylab had a mass of 199,750 pounds (90,610 kg) with a 31,000-pound (14,000 kg) Apollo command and service module (CSM) attached and included a workshop, a solar observatory, and several hundred life science and physical science experiments. It was launched uncrewed into low Earth orbit by a Saturn V rocket modified to be similar to the Saturn INT-21, with the S-IVB, with Skylab itself being the repurposed third stage. This was the final flight for the rocket more commonly known for carrying the crewed Apollo Moon landing missions. Three subsequent missions delivered three-astronaut crews in the Apollo CSM launched by the smaller Saturn IB rocket.

Skylab included the Apollo Telescope Mount (a multi-spectral solar observatory), a multiple docking adapter with two docking ports, an airlock module with extravehicular activity (EVA) hatches, and the orbital workshop, the main habitable space inside Skylab. Electrical power came from solar arrays and fuel cells in the docked Apollo CSM. The rear of the station included a large waste tank, propellant tanks for maneuvering jets, and a heat radiator. Astronauts conducted numerous experiments aboard Skylab during its operational life.

For the final two crewed missions to Skylab, NASA assembled a backup Apollo CSM/Saturn IB in case an in-orbit rescue mission was needed, but this vehicle was never flown. The station was damaged during launch when the micrometeoroid shield tore away from the workshop, taking one of the main solar panel arrays with it and jamming the other main array. This deprived Skylab of most of its electrical power and also removed protection from intense solar heating, threatening to make it unusable. The first crew deployed a replacement heat shade and freed the jammed solar panels to save Skylab. This was the first time that a repair of this magnitude was performed in space.

The Apollo Telescope significantly advanced solar science, and observation of the Sun was unprecedented. Astronauts took thousands of photographs of Earth, and the Earth Resources Experiment Package (EREP) viewed Earth with sensors that recorded data in the visible, infrared, and microwave spectral regions. The record for human time spent in orbit was extended beyond the 23 days set by the Soyuz 11 crew aboard Salyut 1 to 84 days by the Skylab 4 crew.

Later plans to reuse Skylab were stymied by delays in the development of the Space Shuttle, and Skylab's decaying orbit could not be stopped. Skylab's atmospheric reentry began on July 11, 1979, amid worldwide media attention. Before re-entry, NASA ground controllers tried to adjust Skylab's orbit to minimize the risk of debris landing in populated areas, targeting the south Indian Ocean, which was partially successful. Debris showered Western Australia, and recovered pieces indicated that the station had disintegrated lower than expected. As the Skylab program drew to a close, NASA's focus had shifted to the development of the Space Shuttle. NASA space station and laboratory projects included Spacelab, Shuttle-Mir, and Space Station Freedom, which was merged into the International Space Station.

Rocket engineer Wernher von Braun, science fiction writer Arthur C. Clarke, and other early advocates of crewed space travel, expected until the 1960s that a space station would be an important early step in space exploration. Von Braun participated in the publishing of a series of influential articles in Collier's magazine from 1952 to 1954, titled "Man Will Conquer Space Soon!". He envisioned a large, circular station 250 feet (75 m) in diameter that would rotate to generate artificial gravity and require a fleet of 7,000 short tons (6,400 metric tons) space shuttles for construction in orbit. The 80 men aboard the station would include astronomers operating a telescope, meteorologists to forecast the weather, and soldiers to conduct surveillance. Von Braun expected that future expeditions to the Moon and Mars would leave from the station.