Hubbry Logo
PHACE syndromePHACE syndromeMain
Open search
PHACE syndrome
Community hub
PHACE syndrome
logo
7 pages, 0 posts
0 subscribers
Be the first to start a discussion here.
Be the first to start a discussion here.
PHACE syndrome
PHACE syndrome
PHACE syndrome
View on Wikipedia
from Wikipedia
PHACE Syndrome
Other namesPascual–Castroviejo type II syndrome, P-CIIS, Pascual–Castroviejo syndrome type 2[1]
SpecialtyMedical genetics Edit this on Wikidata

PHACE syndrome is a medical condition characterized by uncommon associations between birth defects of the brain, skin (large facial infantile hemangiomas), arteries, heart and eyes. "PHACE" is an acronym for the parts of the body the syndrome usually impacts:

Sometimes an "S" is added to PHACE making the acronym PHACES; with the "S" standing for "Sternal defects" and/or "Supraumbilical raphe." PHACE syndrome may affect infants with large plaque-type facial hemangiomas.[3] Children who present this skin condition should receive careful ophthalmologic, cardiac, and neurologic assessment. According to one study of infants with large hemangiomas, one-third have symptoms consistent with the diagnosis of PHACE syndrome. The most common are cerebrovascular and cardiovascular anomalies.[4]

Signs and symptoms

[edit]

Hemangiomas associated with PHACE syndrome are generally small or not visible at birth, but often escalate after days or weeks, gradually becoming easier to see. They also tend to cover a large area of the face, head, or neck, either as one lesion or as many individual lesions.

Patients with PHACE syndrome may also experience symptoms such as:

Cause and complications

[edit]

Cause

[edit]

The cause of PHACE syndrome is currently unknown. Researchers believe that it is caused by a postzygotic somatic mosaic mutation, or a mutation that can occur on any autosomal chromosome. Research is complicated due to the mosaic nature of the disease.[5] The disorder may be caused by genetic factors, environmental factors, or a combination of the two.[6]

Complications

[edit]

As it grows, the hemangioma can break down the skin, distort facial features, or get in the way of other vital functions, such as breathing, vision, and hearing. Further complications will depend on what other structures are involved. These could include developmental delay, seizures, headaches, and abnormal muscle tone if the brain is affected.

Diagnosis

[edit]

Since the initial sign of PHACE syndrome is usually a large facial hemangioma, infants born with this condition should be further evaluated to diagnose or rule out PHACE syndrome through a series of radiologic tests such as magnetic resonance images (MRI) or magnetic resonance angiograms (MRA) of the head, neck, and chest. Following the imaging tests, the physician should perform an echocardiogram on the infant to observe any abnormalities. If abnormalities are detected on these scans, the infant may have PHACE syndrome.[7]

Treatment

[edit]

Due to the disorder's rarity, there are no standardized treatment protocols or guidelines and no medical treatment trials for affected individuals as of 2022. Various treatments have been reported in the medical literature as part of single case reports or small series of patients.[8]

Physicians treat specific complications and effects of the disorder in order to improve the lives of patients. Treatment usually involves collaboration between many medical professionals. These medical professionals include, but are not limited to, dermatologists; ophthalmologists; cardiologists; endocrinologists; neurologists and or neurosurgeons; otolaryngologists; dentists; speech pathologists; psychiatrists; and many others.[9]

Management

[edit]

PHACE syndrome needs to be managed by a multidisciplinary team of experts. Additional specialties such as cardiology, ophthalmology, neurology, and neurosurgery may need to be involved. The experts pay close attention to how these children develop throughout school-age.[10][11]

Since the establishment of the PHACE syndrome community non-profit in 2013, it has been raising awareness about the condition, supporting patients and families of those with the disease, and raising money for research into causes and treatment.

History

[edit]

In 1993, a correlation between large facial hemangiomas and brain defects among 9 subjects was reported.[12] 3 years later, a larger case study was published showing a wider spectrum of grouped malformations.[13] The association of anomalies and the PHACES acronym was first coined by Dr. Vail Reese and Dr. Ilona Frieden in 1996, making it a newly described syndrome. A diagnosis is generally made from the physical examination, along with imaging of the head and chest, and an eye examination. PHACE is most commonly diagnosed among female infants. Long-term quality of life varies.

The hemangioma growth phase can last anywhere from 6 to 18 months. Then involution, or healing, of the hemangioma begins. Laser and other surgeries can usually make a substantial positive impact on appearance. Long after the hemangioma recedes, any damage it or the other defects caused may remain. Migraines are common, as are developmental delays.

See also

[edit]

References

[edit]
[edit]
Revisions and contributorsEdit on WikipediaRead on Wikipedia

PHACE syndrome

View on Grokipedia
from Grokipedia
PHACE syndrome is a rare neurocutaneous disorder characterized by the presence of a large segmental , typically greater than 5 cm in diameter on the face or , in association with one or more congenital anomalies involving the posterior fossa brain malformations, arterial anomalies (particularly cerebrovascular), cardiac defects (such as ), ocular abnormalities, and ventral or midline defects (including sternal clefting or supraumbilical raphe). The PHACE derives from these core features—Posterior fossa malformations, Hemangiomas, Arterial anomalies, Cardiac defects, and Eye abnormalities—while the variant PHACES incorporates the S for sternal or supraumbilical anomalies. This condition arises sporadically, without a known hereditary pattern, and is believed to stem from developmental errors in cells during early embryogenesis, around 6 to 8 weeks of . The syndrome predominantly affects females in a 9:1 ratio compared to males and is more frequently reported among and populations, though its exact prevalence remains undetermined due to underdiagnosis. Approximately 25% of infants with large segmental facial hemangiomas meet criteria for PHACE syndrome, highlighting the importance of screening in such cases. Clinical manifestations vary widely in severity but commonly include cerebrovascular anomalies like dysplastic or absent arteries, which can lead to ischemic strokes, and structural brain issues such as Dandy-Walker malformations. Cardiac involvement often features or other outflow tract obstructions, while ocular anomalies may encompass colobomas, cataracts, or optic nerve hypoplasia, potentially resulting in vision impairment. Additional features can involve endocrine dysfunction, , or musculoskeletal anomalies, underscoring the multisystem nature of the disorder. Diagnosis relies on established consensus criteria: a definite diagnosis requires the characteristic hemangioma plus at least one major criterion (e.g., arterial dysplasia or aortic coarctation) or two minor criteria (e.g., or ), with updates refined in 2016 to include ventral midline anomalies as a major category. Evaluation typically involves multidisciplinary imaging, including MRI/MRA for brain and vascular assessment, for cardiac screening, and ophthalmologic examination. Management is supportive and tailored to specific anomalies, often featuring beta-blockers like for regression, antiplatelet therapy to prevent cerebrovascular events, and surgical interventions for structural defects, with long-term follow-up by specialists in , , , and . Genetic counseling is recommended, though no specific is routinely available due to the non-hereditary .

Introduction

Definition and acronym

PHACE syndrome is a rare, sporadic neurocutaneous disorder characterized by the association of a large segmental of the face with one or more congenital anomalies involving the , arterial, cardiac, and ocular systems. The condition is defined by the presence of this hallmark cutaneous feature alongside structural malformations that occur more frequently together than expected by chance. The acronym PHACE stands for Posterior fossa brain malformations, Hemangiomas (large segmental infantile, typically facial), Arterial anomalies, Cardiac defects (such as and ventricular septal defects), and Eye abnormalities. An expanded form, PHACES, incorporates S for Sternal defects or Supraumbilical raphe, accounting for additional ventral developmental anomalies observed in some cases. Synonyms for the disorder include PHACE association, PHACES syndrome, and Pascual-Castroviejo type II syndrome.

Epidemiology

PHACE syndrome is a rare neurocutaneous disorder, with its overall prevalence remaining incompletely characterized due to underdiagnosis and reliance on associated clinical features for identification. Among infants presenting with large segmental infantile hemangiomas (>5 cm) on the face or scalp, the incidence of PHACE syndrome is estimated at 20% to 31%, reflecting the strong association with these cutaneous markers. Regional estimates suggest a prevalence of approximately 6.5 per million live births in some European populations, underscoring its rarity on a population level. The condition demonstrates a marked female predominance, with a female-to-male ratio of approximately 9:1, which has prompted investigations into potential X-linked or hormonal influences, though no definitive genetic basis has been established. This sex disparity is consistent across reported cohorts. PHACE syndrome has been reported across all ethnic groups, with studies suggesting higher risk among individuals of non-White race and ethnicity, though reporting biases may influence observed distributions in understudied regions. Diagnosis typically occurs in early infancy, as the characteristic segmental hemangiomas become evident within the first few weeks of life, often prompting evaluation for associated anomalies. The syndrome's underdiagnosis stems from the need for multidisciplinary assessment to uncover systemic involvement, with many cases identified only after proliferation or complication onset.

Clinical manifestations

Cutaneous features

The cutaneous hallmark of PHACE syndrome is the presence of large segmental infantile hemangiomas, typically exceeding 5 cm in diameter, located on the face, , or . These hemangiomas often appear as plaque-like lesions or confluent erythematous patches that follow dermatomal distributions, such as the segments (V1, V2, or V3), and may present unilaterally or bilaterally. At birth, they can be subtle, manifesting as telangiectatic macules or pale patches, before becoming more prominent. These hemangiomas exhibit a characteristic triphasic growth pattern: rapid proliferation during the first 5 months of life, followed by a plateau phase, and eventual spontaneous involution by ages 5 to 10 years in most cases. Involution often leads to residual skin changes, including telangiectasias, , fibrofatty tissue, or textural irregularities, even after apparent regression. The extent of these changes varies based on the hemangioma's size and depth. The specific location and segmental distribution of the hemangioma correlate with the risk and type of associated extracutaneous anomalies, serving as a primary diagnostic clue. For instance, frontotemporal or frontonasal s are linked to cerebrovascular and ocular issues, while mandibular involvement may indicate cardiovascular defects. In rare cases, PHACE syndrome may occur without a prominent or with only subtle cutaneous findings, complicating initial recognition.

Systemic anomalies

PHACE syndrome is characterized by a spectrum of congenital structural anomalies affecting multiple organ systems, often occurring in association with large segmental infantile hemangiomas of the face and scalp. These systemic features, represented by the acronym components (excluding hemangiomas), include posterior fossa brain malformations, cerebrovascular and cardiovascular anomalies, and ocular abnormalities, with additional ventral midline defects in the expanded PHACES variant. The presence of at least one major anomaly is required for diagnosis, though not all components manifest in every case, and the severity varies widely. Posterior fossa malformations are among the most common structural brain anomalies in PHACE syndrome, occurring in 30% to 81% of cases depending on the cohort studied. Specific types include Dandy-Walker malformation or complex (encompassing vermian hypoplasia and cystic dilatation of the ), or dysplasia, and other midline brain anomalies such as arachnoid cysts or enlarged posterior fossa. These defects arise during early embryogenesis and may contribute to neurological symptoms like developmental delays or seizures, though many are asymptomatic. Arterial anomalies represent the highest-risk and most prevalent systemic feature, affecting 64% to 91% of patients, with cerebrovascular involvement noted in up to 91% in retrospective series. Common manifestations involve the cerebral and cervical arteries, including , , occlusion, , aberrant origin or course (e.g., primitive trigeminal or hypoglossal arteries), and progressive arteriopathy resembling . These vascular irregularities, particularly in the carotid or vertebrobasilar systems, stem from disrupted arterial development and confer significant morbidity risk. Cardiac and aortic defects occur in 41% to 67% of individuals with PHACE syndrome, with being the most frequent, reported in 19% to 30% of cases. Other notable anomalies include right-sided or double , , ventricular septal defects, and systemic venous malformations such as interrupted . These cardiovascular issues often correlate with hemangiomas in specific facial segments (e.g., mandibular) and require early screening due to their potential for life-threatening complications. Ocular abnormalities are identified in 6% to 26% of patients, primarily affecting the posterior segment but occasionally involving anterior structures. Key features encompass (of the iris, , or ), morning glory disc anomaly, , , , retinal vascular anomalies, and less commonly, cataracts or . These eye defects result from aberrant ocular embryogenesis and can lead to vision impairment if untreated. In the PHACES variant, additional ventral and midline defects such as sternal clefting (complete or partial), sternal pits, or supraumbilical raphe are present in 7% to 26% of cases, often linked to hemangiomas in the frontonasal or mandibular segments. These superficial anomalies reflect underlying mesodermal developmental disruptions but are typically less severe than the neurovascular features. Overall, the constellation of anomalies in PHACE syndrome highlights its multisystem nature, necessitating multidisciplinary evaluation.

Pathogenesis

Etiology

PHACE syndrome is a sporadic condition with no documented familial inheritance patterns or family history in reported cases. It occurs without a clear hereditary basis, distinguishing it from inherited neurocutaneous disorders. The etiology is hypothesized to involve somatic mosaic mutations arising during early embryogenesis, particularly affecting cell migration and vascular development. These mutations are thought to occur in a mosaic pattern, impacting specific cell lineages rather than being , which aligns with the non-hereditary presentation. No single causative gene has been confirmed, though potential candidates include the X-linked BCOR gene, RNF213, and TMEM260, with copy number variants (CNVs) identified in regions such as 1q32.1, 3p11.1, and 18p11.31 involving pathways like HIF-1α, VEGF, and . The syndrome's marked female predominance, with a female-to-male ratio of approximately 9:1, remains unexplained by current genetic studies. Environmental factors, such as prenatal exposure to hypoxia or teratogens, have been proposed as possible contributors but remain unproven and unsupported by definitive evidence; potential associations include and previa. Unlike Sturge-Weber syndrome, which is primarily driven by somatic mutations in the GNAQ gene, PHACE syndrome does not feature GNAQ alterations as a primary cause, highlighting its distinct genetic profile.

Pathophysiological mechanisms

PHACE syndrome arises from disruptions in early embryonic development, particularly affecting the formation and patterning of vascular and neural structures between weeks 3 and 12 of , coinciding with key phases of vasculogenesis. This defective embryogenesis leads to a spectrum of anomalies that share a common origin in aberrant cellular processes, often linked to somatic mutations occurring in neural crest-derived cells, which migrate along metameric segments under the influence of . cells, critical for contributing to the tunica media of great arteries and endothelial components of vessels, exhibit impaired migration and differentiation in PHACE syndrome, resulting in abnormal vasculogenesis and broader defects across craniofacial and cardiovascular systems. These cells populate the cephalic region, giving rise to vascular and ; their dysfunction propagates irregularities in vessel wall integrity and branching patterns during embryogenesis. The formation of segmental infantile hemangiomas in PHACE syndrome stems from dysregulated , characterized by excessive endothelial and disorganized vascular assembly. This process involves an imbalance in endothelial progenitor cell trafficking and differentiation, leading to ill-timed vascular growth that mimics but exceeds normal developmental . Regional hypoxia, potentially triggered by initial vascular malformations, further drives this proliferation through stabilization of hypoxia-inducible factors, which upregulate pro-angiogenic pathways and exacerbate vascular instability. Such factors, including HIF-1α, bind to regulatory regions of genes involved in endothelial function, promoting a feedback loop of hypoxic stress and aberrant vessel formation observed in affected tissues. Arterial anomalies in PHACE syndrome, such as dysgenesis, aberrant origins, and narrowing of cerebral and cervical vessels, result from failed remodeling of primitive aortic arches and embryonic arterial networks. During normal embryogenesis, the primitive internal carotid artery develops around day 22–23, with subsequent remodeling by neural crest-derived cells to form mature aorticopulmonary septation and branching; in PHACE, this process is disrupted, leading to persistence of embryonic connections and hypoplasia of major arteries like the internal carotid (affected in 76% of cases). These alterations reflect early interruptions in blood flow dynamics and cellular contributions to vessel walls, often unilateral and ipsilateral to the hemangioma. Brain and eye defects in PHACE syndrome arise from impaired midline signaling pathways during embryogenesis, particularly around weeks 6–8 when craniofacial and structures form. Disruptions in these pathways, influenced by migration failures, lead to posterior fossa malformations and posterior segment eye anomalies, such as optic nerve hypoplasia, by altering the spatial organization of midline facial and neural tissues. This results in structural asymmetries and developmental field defects that parallel the vascular irregularities.

Diagnosis

Clinical criteria

The diagnosis of PHACE syndrome is based on standardized clinical criteria that integrate the presence of a characteristic with specific extracutaneous anomalies, facilitating early identification and multidisciplinary evaluation. These criteria were first established in a consensus statement led by Frieden et al., which categorized anomalies into major and minor types across five organ systems: structural brain, cerebrovascular, cardiovascular, ocular, and ventral/midline. Under these guidelines, definite PHACE syndrome requires a segmental , , or greater than 5 cm in diameter plus at least one major criterion or two minor criteria; possible PHACE is diagnosed with the plus one minor criterion. Major criteria in the 2009 framework include anomalies such as posterior fossa malformations (e.g., Dandy-Walker malformation), arterial dysplasia or aberrant origins of major cerebral or cervical arteries, or other anomalies, posterior segment ocular abnormalities (e.g., hypoplasia), and ventral/midline defects (e.g., sternal cleft or supraumbilical raphe). Minor criteria encompass less severe findings, such as persistence of embryonic arteries, midline brain anomalies, ventricular septal defects, anterior segment ocular issues (e.g., ), and endocrine abnormalities like . This tiered system emphasizes the hemangioma's size and segmental distribution as a key predictor of associated risks, with larger lesions (>5 cm) warranting thorough screening for extracutaneous involvement. The criteria were refined in a 2016 multidisciplinary consensus by Garzon et al., which maintained the core structure but expanded applicability to hemangiomas on the , upper trunk, or proximal upper extremity and incorporated additional ventral developmental defects as explicit major criteria to improve diagnostic precision. Updated definitions include definite PHACE for head/ hemangiomas >5 cm plus one or two minor criteria, or /upper trunk hemangiomas plus two major criteria; possible PHACE extends to head/ hemangiomas plus one criterion, /upper trunk hemangiomas plus one or two minor criteria, or even the absence of a hemangioma with two major criteria in select high-risk cases. These refinements highlight the spectrum of ventral/midline anomalies, such as ectopic or midline hamartomas as criteria, and underscore the need for coordinated assessment by specialists in , , , and to confirm findings. A 2021 study by Endicott et al. further advanced clinical evaluation by revising the topographic mapping of segmental and partial segmental s on the face and , identifying updated borders for mandibular and maxillary segments (e.g., reclassifying preauricular skin to the mandibular segment) and a new C-shaped pattern as high-risk indicators for PHACE-associated anomalies. This mapping approach enhances predictive accuracy, allowing clinicians to stratify risk based on distribution even for smaller or indeterminate lesions that respect segmental boundaries, thereby supporting earlier intervention in multidisciplinary settings.

Diagnostic investigations

Diagnostic investigations for PHACE syndrome are essential to identify and characterize associated anomalies once clinical suspicion arises based on the presence of a segmental or greater than 5 cm in diameter meeting the diagnostic criteria. These investigations typically include and specialized examinations performed in early infancy to guide timely management. Magnetic resonance imaging (MRI) with gadolinium contrast and magnetic resonance angiography (MRA) of the brain, neck, and is the gold standard for detecting posterior fossa brain malformations, such as Dandy-Walker malformation, and cerebrovascular anomalies, including arterial stenoses, dysplasias, or absences. In infants, this procedure is often performed under to ensure safety and image quality due to the need for stillness during scanning. Echocardiography is recommended as an initial screening tool to evaluate for cardiovascular anomalies, particularly or other defects, which occur in up to 67% of cases. A comprehensive ophthalmologic examination, including slit-lamp evaluation and indirect ophthalmoscopy, is performed to identify ocular anomalies such as colobomas, cataracts, or optic nerve hypoplasia. Renal may be considered to screen for structural anomalies as part of assessing ventral or midline developmental defects, though it is not a routine test for all patients. for somatic ism is not routinely recommended due to low diagnostic yield, as no specific pathogenic gene has been consistently identified despite suspected mosaic mutations. These investigations are ideally completed before 3 months of age to facilitate early intervention, with prenatal or MRI emerging as potential tools for detecting posterior fossa anomalies in cases of high suspicion during .

Treatment and management

Hemangioma treatment

The primary treatment for cutaneous s in PHACE syndrome is oral , administered at a dose of 2-3 mg/kg/day in divided doses, which was approved by the FDA in 2014 specifically for proliferating infantile hemangiomas. This nonselective beta-blocker reduces hemangioma proliferation through mechanisms including , inhibition of , and induction of in endothelial cells. In patients with PHACE syndrome, is considered first-line for problematic segmental facial hemangiomas, with studies showing its efficacy in accelerating involution without severe adverse events in most cases when cardiac anomalies are screened. For smaller or superficial hemangiomas, topical timolol maleate (0.5% gel or solution applied twice daily) serves as an alternative beta-blocker therapy, particularly when systemic treatment is not preferred due to potential risks. This approach minimizes systemic absorption and has demonstrated rapid reduction in lesion size for thin, localized lesions in PHACE-associated hemangiomas. Prior to initiating , patients with PHACE syndrome require evaluation, including electrocardiogram (ECG) and monitoring, given the prevalence of structural cardiac and cerebrovascular anomalies that may exacerbate risks such as or . is contraindicated in cases of severe cerebrovascular anomalies or significant cardiac defects where reduction could compromise perfusion. Surgical excision is rarely performed due to the large, segmental nature of PHACE hemangiomas but may be reserved for complications such as persistent ulceration unresponsive to medical therapy. Clinical response to in infantile , including those in PHACE syndrome, typically shows 80-90% acceleration of involution, with randomized trials reporting a mean reduction in volume of approximately 88% after 6 months of treatment at 3 mg/kg/day, and improvement observed in 97% of cases by 12 weeks.

Management of anomalies

Management of anomalies in PHACE syndrome requires a multidisciplinary team approach involving specialists such as dermatologists, cardiologists, neurologists, neurosurgeons, ophthalmologists, and geneticists to address the diverse structural abnormalities on a case-by-case basis, as no unified protocol exists. This tailored strategy focuses on mitigating risks and improving outcomes for each affected system, often integrating monitoring, pharmacological prophylaxis, and surgical interventions. For arterial anomalies, which include dysplastic vessels prone to narrowing, occlusion, or aneurysms, low-dose aspirin prophylaxis (typically 4-5 mg/kg/day, up to 81 mg) is recommended in high-risk patients to reduce the incidence of ischemic stroke, particularly when collateral circulation is insufficient. Endovascular interventions, such as or stenting, may be employed for progressive stenoses or aneurysms, guided by serial imaging with MRI/MRA to assess vessel progression. Cardiac anomalies, most commonly coarctation of the aorta or ventricular septal defects, often necessitate surgical repair in approximately 37% of cases involving abnormalities, with extensive reconstruction sometimes required due to associated vascular dysplasia. Preoperative evaluation with , cardiac MRI, and neurophysiological monitoring is standard to plan interventions and minimize complications. Neurological management emphasizes vigilant monitoring for posterior fossa malformations, such as Dandy-Walker complex, which can lead to ; neurosurgical consultation is advised, with ventriculoperitoneal shunting performed if progressive develops. High-risk patients undergo MRI/MRA at 6 months and 1 year of age, alongside neurological follow-up to detect seizures or developmental delays early. Ophthalmic anomalies, including coloboma or cataracts, are managed conservatively when vision is unaffected, but surgical correction—such as lens extraction for cataracts or repair for —is indicated if occurs. Comprehensive ophthalmic examination, including dilated funduscopy, is essential for timely intervention. Supportive care for sternal defects or clefts often includes feeding therapy, with speech-language pathology evaluation recommended by 24 months to address and nutritional challenges, particularly in infants with associated airway or cardiac issues.

Prognosis and complications

Prognosis

The prognosis of PHACE syndrome is highly variable and largely determined by the extent and severity of associated structural anomalies, particularly those involving the cerebrovascular, cardiovascular, and central nervous systems. With multidisciplinary early intervention, including prompt and targeted of anomalies, overall outcomes are generally favorable, though severe cases carry risks of significant morbidity and occasional mortality from cardiac defects or cerebrovascular complications such as ischemic stroke. In a multicenter cohort of 104 individuals followed beyond age 10, ischemic stroke occurred in only 1.9%, underscoring a relatively low but persistent risk of life-threatening vascular events. assessments in this 2024 multicenter study showed global health scores comparable to population norms, despite common long-term morbidities. Long-term sequelae are common, with neurodevelopmental delays affecting 20-45% of affected individuals, especially those with brain anomalies; these may manifest as language impairments (observed in 44% of a studied cohort), gross motor delays (36%), or learning differences requiring educational support (45%). Ocular abnormalities occur in approximately 20% of cases and are a concern for , potentially leading to or other vision deficits if untreated. Lifelong multidisciplinary follow-up is essential, as cerebrovascular arteriopathy progresses in about 30% of cases into adulthood, necessitating periodic to monitor for , moyamoya-like vasculopathy, or other complications. Factors that improve long-term outlook include early and accurate to facilitate timely interventions, as well as the use of for management, which has been shown to enhance functional and cosmetic outcomes when initiated promptly in appropriately screened patients.

Complications

PHACE syndrome is associated with several potential short- and long-term complications stemming from its multisystem anomalies, particularly those involving the cerebrovascular, cardiac, ophthalmic, and hemangiomatous features. Cerebrovascular anomalies, present in approximately 83% to 91% of cases, confer a significant risk of , with 22 documented instances reported in the literature, most occurring in infancy and linked to progressive arterial stenoses or occlusions. Moyamoya-like vasculopathy, observed in approximately 9% of patients with arterial involvement and follow-up imaging, can lead to further progression of occlusive disease, heightening the potential for ischemic events, though the overall incidence remains low but warrants vigilant monitoring in the first year of life. Cardiac defects, affecting 41% to 67% of individuals, include (19% to 30%) and other anomalies, which, if left unrepaired, can result in due to increased and ventricular strain. Ophthalmic complications arise from associated anomalies such as , cataracts, or , potentially causing permanent vision loss if not addressed promptly through targeted interventions. Hemangiomas in PHACE syndrome may ulcerate, leading to secondary , , or scarring, while those involving critical areas like the airway (e.g., subglottic or oropharyngeal locations) can cause obstruction, resulting in respiratory distress or feeding difficulties. Additional complications include endocrine disturbances from pituitary anomalies, such as or , which may manifest as growth delays or hormonal deficiencies. These risks can often be mitigated through multidisciplinary management strategies, including early surgical or medical interventions.

History and research

Discovery and evolution

PHACE syndrome, a neurocutaneous disorder characterized by the association of large segmental infantile hemangiomas of the face with structural anomalies in multiple organ systems, was initially recognized through scattered case reports prior to its formal description. As early as 1978, Pascual-Castroviejo et al. documented seven female infants with facial and scalp capillary hemangiomas accompanied by vascular and nonvascular intracranial malformations, including cerebral hypoplasia and arterial anomalies, highlighting an early link between cutaneous hemangiomas and cerebrovascular abnormalities. Subsequent reports in the and early 1990s described similar associations, such as cerebrovascular anomalies in infants with extensive facial hemangiomas, but these remained anecdotal and lacked a unifying framework. The syndrome was systematically defined in 1996 by Frieden et al., who coined the acronym PHACE—standing for posterior fossa brain malformations, hemangiomas, arterial anomalies, cardiac defects (including ), and eye abnormalities—based on a review of nine infants with large segmental facial hemangiomas and associated extracutaneous anomalies. This seminal publication synthesized prior isolated observations into a recognizable clinical entity, emphasizing the need for multidisciplinary evaluation to identify and manage the diverse anomalies. Over the following decade, increased awareness led to more reported cases, prompting efforts to standardize diagnosis. In 2009, the PHACE Syndrome Study Group, led by collaborators including Frieden, established formal diagnostic criteria through a consensus process, defining definite PHACE as a or greater than 5 cm in plus at least one major criterion (e.g., arterial anomalies or posterior fossa malformations) or two minor criteria (e.g., eye anomalies or ventral developmental defects). These criteria facilitated earlier identification and screening, marking a shift from anecdotal recognition to evidence-based clinical practice. By 2016, Garzon et al. updated these guidelines, expanding the acronym to PHACES to include sternal clefting or supraumbilical raphe as an additional major criterion, and refining minor criteria to incorporate emerging findings like airway anomalies, thereby enhancing diagnostic precision and care recommendations. This evolution reflects a progression from isolated case descriptions to a multidisciplinary approach involving , , , and , which has improved outcomes through proactive screening and management. These foundational developments continue to inform ongoing into the syndrome's and .

Current research

Recent genetic research on PHACE syndrome has identified potential roles for BCOR mutations in subsets of affected individuals, particularly those exhibiting phenotypic overlap with oculofaciocardiodental (OFCD) syndrome, where BCOR variants disrupt embryogenesis and vascular development. Ongoing somatic sequencing efforts have revealed dysregulation in vascular-related pathways, including RAS/MAPK and PI3K/AKT signaling, with variants in genes such as PIK3CA, RASA3, and THBS2 implicated in abnormal among cohorts of patients. In diagnostics, a study refined segmental mapping of facial and infantile hemangiomas, revising boundaries between segments S2 and S3 and introducing a C-shaped pattern to better predict PHACE association risks, aiding in early identification. Feasibility studies on prenatal imaging have demonstrated the utility of fetal and MRI for detecting posterior fossa anomalies and arterial abnormalities, with case reports confirming diagnoses as early as the second trimester through characteristic features. Therapeutic investigations include trials of as an alternative to for management, with a 2024 case report showing successful regression of a large segmental in a PHACES patient treated orally for several months. For refractory cases, has emerged as a promising option, with reports of its efficacy in reducing size and associated vascular anomalies in patients unresponsive to standard beta-blockers, often administered at low doses with monitoring for side effects like . The PHACE Syndrome International Clinical Registry and Genetic Repository, established at Children's Wisconsin, continues to track long-term outcomes in over 400 participants, facilitating studies on disease progression, , and genotype-phenotype correlations since its in 2007. Key gaps persist in understanding the true incidence of PHACE syndrome, particularly in underrepresented populations from and , as well as its manifestations in adulthood, including cerebrovascular risks. A 2025 review underscores the multifactorial , involving somatic mosaicism and environmental factors, while highlighting the need for targeted therapies addressing specific genetic pathways to improve outcomes beyond symptomatic management.

References

  1. https://www.ncbi.nlm.nih.gov/books/NBK539722/
  2. https://rarediseases.org/rare-diseases/phace-syndrome/
  3. https://publications.aap.org/pediatrics/article/124/5/1447/72152/Consensus-Statement-on-Diagnostic-Criteria-for
  4. https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/1108132
  5. https://eyewiki.org/PHACES_Syndrome
  6. https://accesspediatrics.mhmedical.com/content.aspx?bookid=2674&sectionid=220541273
  7. https://ojrd.biomedcentral.com/articles/10.1186/s13023-025-03899-7
  8. https://pubmed.ncbi.nlm.nih.gov/32610335/
  9. https://jamanetwork.com/journals/jamadermatology/fullarticle/2781293
  10. https://pmc.ncbi.nlm.nih.gov/articles/PMC6001075/
  11. https://pmc.ncbi.nlm.nih.gov/articles/PMC6599593/
  12. https://pmc.ncbi.nlm.nih.gov/articles/PMC4936909/
  13. https://pmc.ncbi.nlm.nih.gov/articles/PMC12232788/
  14. https://birthmark.org/publication/sturge-weber-syndrome-and-port-wine-stains-caused-by-somatic-mutation-in-gnaq/
  15. https://pubmed.ncbi.nlm.nih.gov/30580483/
  16. https://pmc.ncbi.nlm.nih.gov/articles/PMC5967888/
  17. https://pmc.ncbi.nlm.nih.gov/articles/PMC2810616/
  18. https://pmc.ncbi.nlm.nih.gov/articles/PMC3971866/
  19. https://pubmed.ncbi.nlm.nih.gov/19858157/
  20. https://pmc.ncbi.nlm.nih.gov/articles/PMC8459308/
  21. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/205410s000lbl.pdf
  22. https://pmc.ncbi.nlm.nih.gov/articles/PMC4580045/
  23. https://pmc.ncbi.nlm.nih.gov/articles/PMC10457131/
  24. https://publications.aap.org/pediatrics/article/143/1/e20183475/37268/Clinical-Practice-Guideline-for-the-Management-of
  25. https://pubmed.ncbi.nlm.nih.gov/21158749/
  26. https://publications.aap.org/pediatrics/article/131/1/128/30793/Initiation-and-Use-of-Propranolol-for-InfantIle
  27. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/205410s006lbl.pdf
  28. https://childrenswi.org/find-care/birthmarks-and-vascular-anomalies/conditions/phace-syndrome/phace-syndrome-handbook/infantile-hemangiomas-and-phace-syndrome
  29. https://www.nejm.org/doi/full/10.1056/NEJMoa1404710
  30. https://www.ahajournals.org/doi/10.1161/STROKEAHA.112.650952
  31. https://pubmed.ncbi.nlm.nih.gov/38218370/
  32. https://pubmed.ncbi.nlm.nih.gov/27291925/
  33. https://publications.aap.org/pediatrics/article/136/4/e1060/73846/Diagnosis-and-Management-of-Infantile-Hemangioma
  34. https://pmc.ncbi.nlm.nih.gov/articles/PMC10173064/
  35. https://pubmed.ncbi.nlm.nih.gov/740218/
  36. https://pubmed.ncbi.nlm.nih.gov/8607636/
  37. https://pubmed.ncbi.nlm.nih.gov/27659028/
  38. https://jamanetwork.com/journals/jamadermatology/fullarticle/2784296
  39. https://pubmed.ncbi.nlm.nih.gov/32723018/
  40. https://pubmed.ncbi.nlm.nih.gov/39123276/
  41. https://pubmed.ncbi.nlm.nih.gov/23316753/
Add your contribution
Related Hubs
User Avatar
No comments yet.