The long-running television animation The Simpsons has featured a number of fictional products, sometimes spoofs of real-life products, that have subsequently been recreated by real world companies attempting to exploit the popularity of The Simpsons. In 2007, as part of a "reverse product placement" marketing campaign for The Simpsons Movie, real life versions of a number of Simpsons products were sold in 7-Eleven stores. Real cans of Buzz Cola, boxes of Krusty-O's cereal, Squishees, and a special edition (#711) of the Radioactive Man Comic were all sold in stores alongside other The Simpsons merchandise.

Buzz Cola is a brand of cola, and an officially licensed product of 20th Century Studios. Its slogan is "twice the sugar, twice the caffeine". The slogan is a parody of the former Jolt Cola slogan "all the sugar and twice the caffeine". A prior slogan used was "There's a little boogie in every bottle (can)".

Sometimes Buzz Cola is used for making a statement of the advertising industry. In "E-I-E-I-(Annoyed Grunt)" (season 11, 1999) the Simpson family is at the movies watching the ads. Here they watch an Allied Forces soldier storm the Normandy beaches and charge a German. The German falls to the ground dead and the Allied soldier reaches for a can of Buzz Cola in his belt pocket. A voice over then says "Buzz Cola: The taste you kill for!" and then the German comes alive again to say "Available in ze lobby". Jonathan Grey writes in his book Watching With The Simpsons that "the cola ad, for instance, scorns the proclivity of ads to use any gimmick to grasp attention, regardless of ethics".

Although a general parody of popular cola drinks, parallels can be observed between Buzz Cola and Pepsi. For example, many of the mock television commercials that appear for Buzz Cola on The Simpsons follow the same youth-oriented approach of real Pepsi commercials. In another example, Homer gets his arm stuck in a vending machine selling "Crystal Buzz Cola", a parody of Crystal Pepsi. In the episode "Dude, Where's My Ranch?," Maggie Simpson dances in her crib with her midriff exposed while a Britney Spears tune plays in the background and produces a can of Buzz Cola at the end of her small dance, parodying the Pepsi advertising done by Spears in the late 1990s and early 2000s. There is also a "Buzz Cola with Lemon" version of the product, with the slogan "damn, that's a lemony cola". In addition, in a later episode, there was an old ad for Buzz Cola, stating that it has the "rejuvenating power of cocaine" in it. In the video game The Simpsons: Hit & Run, aliens Kang and Kodos use a "new and improved" Buzz Cola formula to brainwash the citizens of Springfield into performing stupid stunts for their reality TV show, Foolish Earthlings. They also dump it into the town's water supply, which reanimates the dead and creates zombies.

In July 2007, 7-Eleven rebranded some stores to look like Kwik-E-Marts in select cities to promote The Simpsons Movie. Real cans of Buzz Cola were available at those locations, as well as most other 7-Elevens throughout the United States and Canada. The soda in these cans was produced by the Cott Corporation, which also makes RC Cola outside the United States.

Buzz Cola first appeared in the 1984 movie Surf II.

With its loud-mouthed corporate spokesperson Duffman, Duff Beer is a parody of stereotypical American beer: cheap, mass-produced, poor-quality and heavily advertised. It is Homer's favorite beer and sold in all the bars of Springfield. Its slogan is "Can't get enough of that wonderful Duff".

The chief competitor of Duff Beer is Fudd Beer, which is intentionally spelled with a parallel swapping of the consonants. ^{[citation needed]} Homer became aware of Fudd Beer while patronizing a "redneck bar" in nearby Spittle County. It was later revealed to be considered very popular in Springfield's rival town of Shelbyville. Moe said he thought it had been banned "after all those hillbillies went blind", suggesting methanol poisoning.