| Reticular pigmented anomaly of the flexures | |
|---|---|
| Other names | Kitamura reticulate acropigmentation[1] |
| Specialty | Dermatology |
Reticular pigmented anomaly of the flexures (also known as dark dot disease and Dowling–Degos disease) is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal areas.[2]: 856 It is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.[3]
Dark dot disease is associated with KRT5.[4]
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