Street Signs was a television business program that originally aired on CNBC, and later aired on CNBC Asia and on CNBC Europe. Before the Asian version debuted on March 31, 2014, it was broadcast on CNBC at 2:00pm ET. The CNBC United States version's final episode aired on February 6, 2015, due to Power Lunch returning to a two-hour format. The European version of Street Signs, which aired in a one-hour format on CNBC Europe, debuted January 4, 2016.

This program focused on the day's market action. In addition, prominent analysts, investors and executives regularly appeared on the program to offer their perspective.

Street Signs was originally a two-hour programme that aired on CNBC from 1996 to February 1, 2002. It was cancelled effective February 4, 2002, and Power Lunch occupied its vacated slot as a result of CNBC's revamped programming line-up. On December 8, 2003, former Business Center co-anchor and original host Ron Insana revived Street Signs. And in March 2006, Squawk on the Street co-anchor Erin Burnett replaced Insana as the programme's new host. Burnett left CNBC on May 6, 2011. After Erin Burnett's departure Amanda Drury (late of CNBC Asia) and Brian Sullivan (late of the Fox Business Network) became this program's new anchor team and were to be the show's final anchors.

On October 13, 2014, Street Signs was launched in full 1080i high-definition as part of CNBC's network-wide switch to a full 16:9 letterbox presentation.

One notable segment of the programme, which aired at 2:40pm ET, the "Stop Trading!" segment, was presented by Jim Cramer (host of another CNBC program, Mad Money). In this segment, which formerly aired on Closing Bell prior to September 11, 2006, the co-anchors asked Cramer about the stocks making news, and also asked him for his take on the day's markets. After the segment, a full-screen disclaimer was shown as Street Signs go to a commercial break. Cramer's "Stop Trading!" segment was moved to the end of the first hour of Squawk on the Street on February 9, 2015. Jim Cramer's on-air tirade about the weakening economy, which was seen during the "Stop Trading!" segment of this program on August 3, 2007, garnered widespread attention and helped galvanise the Federal Reserve Board to cut interest rates.

From its January 4, 2016, debut through September 30, 2020, on Mondays from October 12, 2020, to October 24, 2022, and again on weekdays since November 7, 2022, the European version of Street Signs is the only CNBC Europe program that is aired on CNBC's United States channel. Coincidentally (as previously mentioned), CNBC's own version of Street Signs aired its last show 11 months earlier, on February 6, 2015.

CNBC Asia's version of Street Signs debuted March 31, 2014, with Martin Soong and Oriel Morrison as co-anchors. Soong was previously a longtime co-anchor of Asia Squawk Box (he has since returned to that show in the same role) and Morrison was anchor of the now-cancelled Cash Flow. Beginning December 2, 2019, the anchor team consisted of Tanvir Gill and Nancy Hungerford, both of whom replaced Morrison and Soong as co-anchors on that date. Hungerford departed from CNBC on July 2, 2021, and since July 5 of that same year until early 2022, Gill has been working with other fill-in presenters, such as Amanda Drury (former co-anchor of the defunct US version) and Christine Tan. As of July 2024, Street Signs Asia is anchored by Gill and Samantha Vadas (the later of whom replaced Will Koulouris, who before that, replaced the then-returning Teymoor Nabili). The background music for the Asian and European versions were the same as CNBC Asia's The Rundown and CNBC United States' Squawk Alley (the latter two shows no longer air as of July 2021). This version of Street Signs changed its theme music, graphics and adopted US-based titles on July 22, 2024.

This programme originally aired in a two-hour format until October 29, 2018, when it was expanded to three hours (9:00 a.m. – 12:00 p.m. SIN/HK) due to the cancellation of The Rundown.