Alice Suki Waterhouse was born in Hammersmith, London, England, to Norman Waterhouse, a plastic surgeon, and Elizabeth, a cancer care nurse. Her upbringing in a creative environment in West London, with a surgeon father who also designed furniture as a side interest, provided a foundation for her later artistic pursuits.

At the age of 16, Waterhouse began her modeling career after being scouted while shopping in London. This marked the start of her professional journey into the world of fashion, paving the way for her appearances in major campaigns and runway shows.

Waterhouse achieved significant success in the high-fashion industry, working with prominent brands like Burberry, Redken, and Tommy Hilfiger. She also graced the covers of prestigious magazines such as Vogue, Elle, and Tatler. This period solidified her status as a sought-after model on the international stage.

Waterhouse transitioned into acting with a small role in the British crime thriller 'Pusher'. Although a minor part, this marked her first foray into the world of film and set the stage for future acting endeavors.

Waterhouse gained wider recognition for her role as Bethany Williams in the romantic comedy 'Love, Rosie'. This role helped to elevate her profile as an actress and exposed her talent to a broader audience.

Waterhouse took on more substantial acting roles in 2016, appearing in the comedic horror film 'Pride and Prejudice and Zombies' and Ana Lily Amirpour's dystopian thriller 'The Bad Batch'. These roles demonstrated her versatility as an actress and her willingness to explore different genres.

Waterhouse continued to build her acting resume with roles in films like 'Assassination Nation' (2018), 'Detective Pikachu' (2019) and 'Persuasion' (2022). These roles showcased her growing range and cemented her presence in the film industry. She also took on roles in television series, including 'Daisy Jones & The Six' (2023).

Suki Waterhouse starred in the critically acclaimed Amazon Prime Video series 'Daisy Jones & The Six', based on the novel by Taylor Jenkins Reid. Her role as Karen Sirko was well-received, further enhancing her profile as a versatile actress and musician as she also contributed to the show's soundtrack.