The Bernie Mac Show (often shortened to Bernie Mac in syndication and promos) is an American sitcom television series created by Larry Wilmore, that aired on Fox for five seasons from November 14, 2001, to April 14, 2006. The series featured Bernie Mac and his wife Wanda raising his sister's three kids: Jordan, Vanessa, and Bryana.

The series was loosely based on Mac's stand-up comedy acts. In real life, Bernie "Mac" McCullough was married with one daughter; Mac's character on the show (a stand-up comedian) was married with no children of his own. The pilot episode, aired on November 14, 2001, set up the basic premise for the series: the character Bernie Mac takes in his sister's children after she enters rehab (a fictional premise taken from one of Mac's stand-up routines which was eventually featured in the 2000 film, The Original Kings of Comedy). "In reality, the story is a blend of two real incidents: Mac briefly took in his niece Toya who was an at risk youth and her daughter Monique; a friend of his had to raise her sister's children long-term."

Much of the humor in the show was derived from Mac's continual adjustment to and his unique take on parenthood. A frequent motif of the show was the juxtaposition of Mac's acerbic comments, such as his threats to "bust the (children's) heads 'til the white meat shows," and the parental affection he felt toward the trio, which often brought him to the verge of tears. Toward the end of the series, Bryana's long-lost father (Anthony Anderson) returns and drops by occasionally to help Bernie and Wanda with the kids.

Many of his most emotional scenes occurred in segments in which Mac, while still in character, broke the 'fourth wall' and talked to the television audience, which he referred to as "America". This technique was notably used before an episode during the 2005–2006 season, when Bernie, as himself and wearing a Chicago White Sox cap and jacket, delivered a heartfelt congratulatory message to the baseball organization and its staff on their recent World Series Championship. Mac, who grew up on Chicago's south-side, was a die-hard fan of the White Sox and was seen at Game 1 of the World Series, in a front row seat.

The show also features yellow captions pointing things out that aren't explicitly mentioned.

Mac's character's celebrity worked as a plot device allowing other celebrities to appear on the show as themselves, including Halle Berry, Serena Williams, Chris Rock, Ashton Kutcher, Billy Crystal, Carl Reiner, Don Rickles, Angela Bassett, Ellen DeGeneres, Ice Cube, Isaac Hayes, Flavor Flav, Lucy Lawless, Stone Cold Steve Austin, Triple H, Matt Damon, Charles Barkley, Jon Garland, Jules Sylvester, Sugar Ray Leonard, India Arie, Shaquille O'Neal, Sugar Shane Mosley, Hugh Hefner, Phil McGraw, Jay Leno, and Marcus Allen.

The series debuted in its time slot on November 14, 2001, with solid ratings in spite of a weak lead-in, Grounded for Life. The show had a very successful first season and in the process won a handful of honors including an Emmy Award for "Outstanding Writing for a Comedy Series" and the prestigious Peabody Award. Bernie Mac also received Emmy and Golden Globe nominations for Best Actor in a Comedy Series.

In fall 2002, the series aired against the Damon Wayans comedy My Wife and Kids which may have hurt the show's momentum in the ratings during the first half of its second season run. Larry Wilmore, the show's creator and executive producer, was fired at this time. In interviews, Wilmore said he was fed up with the network's creative interference with the show, in addition to Fox constantly shuffling it around the schedule. Fox contended that it wasn't happy with the show's direction under Wilmore in the second season, claiming the show "wasn't delivering enough laughs". With The Bernie Mac Show's inability to topple My Wife and Kids in the Wednesday 8 p.m. timeslot, Fox eventually aired the show after American Idol, after which it received its highest ratings ever.