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Tributyl phosphate
Tributyl phosphate
Tributyl phosphate
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Tributyl phosphate
Spacefill model of Tributyl phosphate
Spacefill model of Tributyl phosphate
Ball and stick model of Tributyl phosphate
Ball and stick model of Tributyl phosphate
Names
Preferred IUPAC name
Tributyl phosphate
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.004.365 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C12H27O4P/c1-4-7-10-14-17(13,15-11-8-5-2)16-12-9-6-3/h4-12H2,1-3H3 checkY
    Key: STCOOQWBFONSKY-UHFFFAOYSA-N checkY
  • InChI=1/C12H27O4P/c1-4-7-10-14-17(13,15-11-8-5-2)16-12-9-6-3/h4-12H2,1-3H3
    Key: STCOOQWBFONSKY-UHFFFAOYAN
  • O=P(OCCCC)(OCCCC)OCCCC
Properties
C12H27O4P
Molar mass 266.318 g·mol−1
Appearance Colorless to pale-yellow liquid[1]
Density 0.9727 g/mL
Melting point −80 °C (−112 °F; 193 K)
Boiling point 289 °C (552 °F; 562 K)
0.4 g/L[2]
Vapor pressure 0.004 mmHg (25°C)[1]
1.4231 (at 20 °C) [3]
Hazards
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g. chloroformFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 1: Normally stable, but can become unstable at elevated temperatures and pressures. E.g. calciumSpecial hazards (white): no code
2
1
1
Flash point 146.1 °C (295.0 °F; 419.2 K)
Lethal dose or concentration (LD, LC):
1189 mg/kg (mouse, oral)
3000 mg/kg (rat, oral)[4]
227 ppm (cat, 4–5 h)
123 ppm (rat, 6 h)
117 ppm (rat)
2529 ppm (rat, 1 h)[4]
2214 ppm (cat, 5 h)[4]
NIOSH (US health exposure limits):
PEL (Permissible)
 TWA 5 mg/m3[1]
REL (Recommended)
 TWA 0.2 ppm (2.5 mg/m3)[1]
IDLH (Immediate danger)
 30 ppm[1]
Safety data sheet (SDS) External MSDS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Tributyl phosphate, known commonly as TBP, is an organophosphorus compound with the chemical formula (CH3CH2CH2CH2O)3PO. This colourless, odorless liquid finds some applications as an extractant and a plasticizer. It is an ester of phosphoric acid with n-butanol.

Production

[edit]

Tributyl phosphate is manufactured by reaction of phosphoryl chloride with n-butanol.[5]

POCl3 + 3 C4H9OH → PO(OC4H9)3 + 3 HCl

Production is estimated at 3,000–5,000 tonnes worldwide.[6]

Use

[edit]

TBP is a solvent and plasticizer for cellulose esters such as nitrocellulose and cellulose acetate, similarly to tricresyl phosphate. It is also used as a flame retardant for cellulose fabrics such as cotton.[7][8] It forms stable hydrophobic complexes with some metals; these complexes are soluble in organic solvents as well as supercritical CO2. The major uses of TBP in industry are as a component of aircraft hydraulic fluid, brake fluid, and as a solvent for extraction and purification of rare-earth metals from their ores.[6]

TBP finds its use as a solvent in inks, synthetic resins, gums, adhesives (namely for veneer plywood), and herbicide and fungicide concentrates.

As it has no odour, it is used as an anti-foaming agent in detergent solutions, and in various emulsions, paints, and adhesives. It is also found as a de-foamer in ethylene glycol-borax antifreeze solutions.[citation needed] In oil-based lubricants addition of TBP increases the oil film strength. It is used also in mercerizing liquids, where it improves their wetting properties. It can be used as a heat-exchange medium.[9] TBP is used in some consumer products such as herbicides and water-thinned paints and tinting bases.[10]

Nuclear chemistry

[edit]

Tributyl phosphate is used in combination with di(2-ethylhexyl)phosphoric acid for the solvent extraction of uranium, as part of the purification of natural ores.[11] It is also used in nuclear reprocessing as part of the PUREX process. A 15–40% (usually about 30%) solution of tributyl phosphate in kerosene or dodecane is used in the liquid–liquid extraction (solvent extraction) of uranium, plutonium, and thorium from spent uranium nuclear fuel rods dissolved in nitric acid. Liquid extraction can also be used for chemical uranium enrichment.[12]

Hazards

[edit]

In contact with concentrated nitric acid the TBP-kerosene solution forms hazardous and explosive red oil.

References

[edit]
Revisions and contributorsEdit on WikipediaRead on Wikipedia

Tributyl phosphate

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from Grokipedia
Tributyl phosphate (TBP), also known as tri-n-butyl phosphate, is an organophosphorus compound with the molecular formula C₁₂H₂₇O₄P. It is a colorless, odorless that serves primarily as a and extractant in industrial applications. TBP's most prominent use is in the process for reprocessing, where it selectively extracts (VI) and (IV) from solutions, facilitating the separation of fissile materials from . Beyond , it functions as a for esters and resins, a component in aircraft hydraulic fluids and brake fluids, and a in polymers. Its solvency properties also find application in extracting rare-earth metals and as a defoaming agent. The compound exhibits moderate toxicity, classified as harmful if swallowed (Acute Toxicity Category 4), a skin irritant, and suspected of carcinogenicity based on . Inhalation or can lead to effects, while environmental release poses risks to aquatic life due to its persistence and potential. Despite these hazards, TBP remains essential in specialized owing to its chemical stability and extraction efficiency under acidic conditions.

Physical and Chemical Properties

Molecular Structure and Characteristics

Tributyl phosphate (TBP), with the molecular formula C12H27O4P, is a trialkyl ester derived from , consisting of a central (V) atom bonded to one oxo group (P=O) and three n-butoxy groups via P-O-C linkages. This tetrahedral organophosphorus structure features ester bonds that link the polar phosphoryl moiety to the hydrophobic butyl chains (CH3(CH2)3-), conferring amphiphilic properties essential for its function as a neutral solvating . The polarity of TBP arises primarily from the electron-withdrawing P=O bond and the oxygen lone pairs in the P-O-C framework, enabling coordination to Lewis acidic metal cations such as (UO22+) through donor-acceptor interactions. These structural elements underpin its solvency for polar metal complexes, allowing selective extraction from aqueous phases into organic media while the alkyl chains promote solubility in nonpolar diluents like or . Relative to triethyl phosphate, which bears shorter ethyl chains and exhibits higher hydrophilicity, TBP displays increased that enhances organic-phase partitioning and extraction distribution ratios for actinides, though it may form third phases under high metal loading. In comparison, trioctyl phosphate with longer octyl chains offers even greater and potentially stronger extraction for certain metals but at the cost of higher , which can impede kinetics in . This intermediate chain length in TBP optimizes the balance between power and phase compatibility for extractant applications.

Physical Properties

Tributyl phosphate (TBP) is a colorless to pale yellow, odorless liquid at ambient temperatures, with a molecular weight of 266.32 g/mol. Its low volatility is indicated by a of approximately 0.15 Pa at 25 °C and a relative vapor density of 9.2. Key physical constants include a of −80 °C and a of 289 °C at standard pressure. Density ranges from 0.972 to 0.979 g/cm³ at 20 °C, while dynamic is approximately 3.4 mPa·s at 20 °C, influencing its flow characteristics in industrial handling and storage.
PropertyValueConditions
Density0.977 g/cm³20 °C
Viscosity3.5 mPa·s25 °C
Water solubility0.28–0.4 g/L25 °C
TBP shows low solubility in (0.28–0.4 g/L at 25 °C) but is miscible with many organic solvents, such as alcohols, ethers, , and hydrocarbons like or , facilitating its dilution in non-polar media for process applications. This solubility profile supports efficient in extraction systems.

Chemical Reactivity and Stability

Tributyl phosphate (TBP) exhibits moderate chemical stability under ambient conditions but is prone to degradation via , particularly in aqueous environments. Hydrolytic cleavage occurs stepwise, primarily cleaving the butyl ester bonds to yield and partially hydrolyzed products such as dibutyl phosphate (DBP) and monobutyl phosphate (MBP). This reaction is catalyzed by acids or bases, with alkaline conditions accelerating the process, though neutral hydrolysis proceeds more slowly. TBP demonstrates resistance to oxidation in the absence of strong oxidants, maintaining structural integrity in diluents without significant formation. In radiation-exposed settings, such as reprocessing, TBP undergoes , breaking C-O bonds and generating DBP and MBP as primary degradation products. These derivatives can coordinate with metal ions, potentially forming insoluble complexes or precipitates that alter solvent performance. Alpha and gamma enhance rates, with plutonium-induced alpha particles promoting both direct bond scission and indirect hydrolytic pathways. TBP interacts exothermically with concentrated , especially at elevated temperatures, leading to oxidation of TBP or its hydrolytic byproducts like . This pathway initiates the formation of "red oil," a viscous of nitro compounds and organic nitrates, through sequential and oxidation steps. Such reactions pose risks of runaway thermal events due to autocatalytic heat release, though TBP itself remains relatively inert below 100°C in dilute acids. Overall, while TBP's P-O bonds confer inherent stability against mild chemical attack, targeted degradation under hydrolytic, radiative, or oxidative stresses necessitates careful process controls in industrial applications.

History and Development

Early Synthesis and Discovery

Tributyl phosphate was synthesized through the esterification of oxychloride (POCl₃) with n-butanol, yielding the triester product while generating as a that requires removal to drive the reaction forward. This approach, a standard method for preparing trialkyl phosphates, emerged in the early amid advances in following the isolation of POCl₃ in the mid-19th century. Initial recognition of tributyl phosphate focused on its potential as a and , with patents in the 1930s and 1940s exploring esters for industrial applications unrelated to nuclear processing. These developments preceded widespread adoption, as early efforts emphasized mixed or aryl phosphates for lubricants and additives in machinery like aircraft engines. Prior to , academic interest in tributyl phosphate specifically was minimal, constrained by the limited commercial availability of precursors outside specialized . expansion of the industry provided abundant compounds, spurring greater investigation into alkyl phosphates like tributyl phosphate for diverse properties.

Adoption in Nuclear and Industrial Applications

Tributyl phosphate (TBP) emerged as a key extractant during the in the early 1940s, where its ability to selectively remove transuranic elements from aqueous solutions was first recognized by U.S. researchers developing separation methods. Initial trials focused on its solvent properties for metal ions, transitioning from earlier bismuth phosphate precipitation techniques to organic solvent extraction. This laid the groundwork for TBP's integration into production-scale processes by the mid-1950s, as facilities like Hanford's plant began operations in 1956 using TBP in diluents for and recovery from irradiated fuel. Similarly, the implemented large-scale runs in 1954, marking TBP's shift from experimental to standardized industrial extraction in nuclear programs. Parallel to nuclear advancements, TBP saw post-1950 adoption in non-nuclear sectors amid the and plastics expansions. In hydraulic fluids for , TBP served as a fire-resistant additive and anti-wear agent, aligning with the jet age's demand for high-performance lubricants capable of withstanding extreme pressures. Its role in flame retardants grew concurrently, incorporated into plastics and resins to enhance fire safety during the synthetic polymer boom following . By the 1960s, TBP's use proliferated in global , with facilities in the U.S., , , and other nations standardizing variants for efficient separation, replacing less selective earlier solvents like hexone. This era solidified TBP's dual-role prominence, balancing nuclear demands with industrial applications in extraction solvents for rare earths and purification aids.

Production Methods

Industrial Synthesis Processes

The primary industrial synthesis of tributyl phosphate (TBP) involves the stepwise esterification of (POCl₃) with excess n-butanol in batch or semi-batch reactors. The overall reaction is POCl₃ + 3 C₄H₉OH → (C₄H₉O)₃PO + 3 HCl, which proceeds exothermically and requires gradual addition of alcohol to POCl₃ under cooling to maintain temperatures around 40–60°C, preventing or side products like partially esterified phosphates. Following esterification, the HCl byproduct is neutralized with aqueous (e.g., NaOH) to form , or removed via with hydrocarbons like n-pentane to enhance conversion and avoid . Excess n-butanol is recovered by atmospheric , while the crude TBP undergoes fractional to separate impurities such as dibutyl phosphate (formed by inadvertent ) and achieve >99% purity. Overall yields typically range from 90% to 95%, optimized by conditions, precise 1:3–1:8 POCl₃-to-butanol ratios, and monitoring for acid content. Variations include continuous systems using T-junction mixers, which improve and safety for the exothermic process, attaining near-quantitative yields (up to 100%) at residence times of 44 minutes and 60°C. Alternative routes, such as esterification of orthophosphoric acid with n-butanol under dehydrating conditions or from lower alkyl phosphates (e.g., triethyl phosphate), are employed less frequently due to equilibrium limitations requiring catalysts or azeotropes, resulting in lower compared to the POCl₃ method.

Key Raw Materials and Scale

Tributyl phosphate production depends on n-butanol and phosphorus oxychloride as primary raw materials, with n-butanol sourced mainly from petrochemical routes involving propylene hydroformylation, though bio-based fermentation processes offer an alternative pathway using renewable feedstocks like sugars. Phosphorus oxychloride derives from phosphorus compounds ultimately extracted from phosphate rock via thermal or wet processes, with global phosphate mining concentrated in regions like Morocco and the United States. Global production capacity stands at an estimated 50,000 to 100,000 metric tons per year as of the early 2020s, inferred from market valuations of approximately USD 250–290 million and prevailing prices, with output dominated by facilities in , followed by the and European producers. This scale supports key applications in extraction and solvents, though exact capacities remain proprietary among major chemical firms. Commercial prices for tributyl phosphate range from USD 2 to 5 per , subject to fluctuations tied to crude oil costs via n-butanol's linkage, with recent initiatives exploring from and agricultural runoff to mitigate vulnerabilities from finite rock reserves.

Applications

Nuclear Fuel Reprocessing

Tributyl phosphate (TBP) functions as the key organic extractant in the (plutonium uranium redox extraction) process, the predominant method for reprocessing to recover and . Diluted to approximately 30% by volume in a diluent, TBP enables selective solvent extraction by forming stable nitrato complexes with hexavalent uranium (U(VI)) and tetravalent plutonium (Pu(IV)) from acidic aqueous solutions of dissolved fuel. This selectivity arises from TBP's ability to coordinate with nitrates while exhibiting low affinity for most fission products and structural materials, facilitating their separation into distinct streams. The operational sequence involves shearing and dissolving fuel assemblies in 7-10 M nitric acid, followed by feed adjustment to 3-4 M HNO3 for co-extraction in pulsed or mixer-settler columns across multiple stages: typically 20-30 stages for initial actinide removal, with subsequent partitioning cycles for U/Pu separation via reduction of Pu to Pu(III) and selective stripping using dilute nitric acid or aqueous reductants like hydroxylamine or ferrous sulfamate. The high nitric acid concentration promotes "salting out" of actinides into the organic phase, while phase disengagement is optimized by the kerosene diluent's low viscosity and density. Solvent streams are scrubbed with water or carbonate solutions to remove entrained impurities before recycling. TBP's advantages in include its chemical stability under radiolytic and oxidative conditions, allowing solvent recycling with recovery efficiencies often exceeding 90% per cycle after purification to remove degradation products like dibutyl phosphoric acid. This recyclability, combined with high distribution coefficients for actinides (e.g., D_U > 10 in 3 M HNO3), supports efficient , reducing the volume of by isolating recyclable and —comprising over 95% of the original fuel mass—while concentrating fission products into a smaller vitrifiable . Deployed at scale in facilities such as the Hanford PUREX plant (operational from 1956) in the United States, which processed over 30,000 metric tons of fuel, and the La Hague complex in (processing capacity ~1,700 tons/year as of recent operations), the process has proven effective for closing the fuel cycle and minimizing long-term repository burdens.

Industrial and Commercial Uses

Tributyl phosphate (TBP) serves as a in the production of (PVC), , synthetic rubbers, lacquers, and vinyl resins, enhancing flexibility and processability in these materials. It is also incorporated as a in coatings, adhesives, and plastics, where it contributes to improved fire resistance without halogenated compounds. In polyurethane foams and textiles, TBP functions as a agent and auxiliary , aiding in material dispersion and surface treatment during manufacturing. As an antifoam agent, it is applied in paints, inks, paper processing, and emulsions to control formation and improve product stability. TBP is a key component in fire-resistant hydraulic fluids, where it provides low-temperature fluidity with pour points as low as -80°F, ensuring operational reliability in extreme conditions. In extraction , it acts as a for separating rare earth elements from ores via solvent extraction processes, often in systems for selective recovery. Minor applications include its use in adhesives as a and additive.

Emerging and Specialized Uses

In , tributyl phosphate (TBP) serves as a agent that disrupts cellular proteins and lipids while preserving the structure and avoiding DNA fragmentation, enabling scaffold production for regenerative applications. A 2010 study demonstrated that treatment with 1% TBP effectively eliminated cell nuclei from porcine tendons, maintaining fibril alignment and biomechanical properties comparable to native tissue, outperforming harsher detergents like SDS in preserving glycosaminoglycans. Subsequent research has validated TBP's efficacy in decellularizing diverse tissues, such as rat tail and , where it minimizes residual cellular debris and supports recellularization without eliciting strong immune responses in implantation models. This approach, gaining traction since the early , addresses limitations of traditional ionic detergents by offering a milder, solvent-based protocol suitable for load-bearing tissues like tendons and ligaments. For medical isotope production, TBP features in modified solvent extraction processes to isolate molybdenum-99 (Mo-99), the precursor to technetium-99m used in diagnostic imaging. In accelerator-based or non-uranium pathways, 30-50% TBP diluted in diluents like 1-octanol or tetrachloroethylene extracts Mo-99 from irradiated targets, achieving high separation factors from impurities such as molybdenum carriers or fission byproducts. This adaptation of PUREX-like chemistry, explored in studies from 2015 onward, supports domestic Mo-99 supply chains independent of highly enriched uranium reactors, with extraction efficiencies exceeding 90% under optimized pH and phase contact conditions. Such methods enhance scalability for clinical demands, projected to rise with global nuclear medicine procedures increasing by 5-10% annually through the 2020s. The global TBP market, valued at $290 million in 2023, is forecasted to expand to $440 million by 2033 at a of about 4.3%, propelled by rising demand for phosphorus-based flame retardants in components and efficient solvents amid stricter environmental regulations. Innovations in halogen-free formulations leverage TBP's content for char formation in battery casings and wiring insulation, aligning with EV production surges—global sales exceeding 14 million units in 2023—and mandates like the EU's REACH framework favoring low-volatility extractants over volatile organics. These trends underscore TBP's shift toward high-value niches, contrasting stagnant legacy solvent uses, with regions capturing over 40% due to and automotive growth.

Safety, Hazards, and Risks

Human Health Effects

Tributyl phosphate (TBP) causes acute to and eyes upon direct contact, with symptoms including redness and discomfort. of vapors at occupational levels, such as 15 mg/m³ (1.4 ppm), has been associated with human reports of and . High acute exposures via may lead to respiratory distress, drowsiness, tremors, convulsions, or coma. Oral administration in rodents yields an LD50 of approximately 1.5–3 g/kg body weight, indicating moderate . Chronic exposure studies in animals demonstrate TBP as a non-genotoxic , primarily through mechanisms of and regenerative rather than DNA damage. In rats, dietary levels exceeding 200 ppm (about 9 mg/kg/day) induced urinary bladder tumors, with no-observed-effect levels (NOEL) at 200 ppm for ; higher doses (700–3000 ppm) showed increased incidence in males. Similar oncogenicity occurred in mice above 150 ppm (24 mg/kg/day), alongside effects like increased liver, , and testis weights. Limited human epidemiological data exist, but regulatory classifications label TBP as a suspected carcinogen (Category 2) based on these animal findings. Primary human exposure routes are occupational, via dermal absorption (the dominant pathway due to TBP's in ) or of vapors during handling. General population risks remain low, as TBP lacks significant environmental persistence leading to broad exposure, per U.S. EPA assessments emphasizing controlled industrial use.

Environmental Persistence and Impact

Tributyl phosphate (TBP) exhibits moderate environmental persistence, primarily undergoing through microbial in and environments. In aerobic conditions, TBP degrades stepwise via enzymatic processes to orthophosphate and n-butanol, with ready biodegradation tests demonstrating 89–90.8% removal in 28 days under standardized conditions. However, field persistence is slower, influenced by availability, with adsorption to sediments reducing mobility and . Abiotic occurs via base-catalyzed mechanisms but proceeds slowly in neutral waters, showing no significant degradation after 30 days in sterile conditions at pH 7. Bioaccumulation potential is low despite a log Kow of approximately 4.0, as evidenced by of 6–49 in species such as and , with rapid depuration ( of 1.25 hours). This limited uptake stems from metabolic transformation rather than hydrophobicity alone, and TBP does not meet regulatory criteria for under persistence and frameworks. TBP has been detected in effluents from industrial sources, including plastics processing and nuclear facilities, at concentrations typically ranging from 0.6 to 1,422 ng/L, well below 1 mg/L thresholds that might pose acute risks. Degradation products, particularly orthophosphate, pose a potential risk if released in volume, as loading can promote algal blooms in nutrient-limited waters, though empirical instances tied directly to TBP remain undocumented at scale. monitoring reveals sporadic low-level detections (<1 μg/L), often associated with legacy sites but without widespread contamination plumes, as TBP's adsorption and biodegradation limit long-range transport. In nuclear fuel reprocessing contexts, TBP's use facilitates uranium and plutonium recovery, reducing high-level waste volumes by up to 95% compared to direct disposal and thereby decreasing the environmental footprint of new uranium mining, which involves extensive land disturbance and tailings generation. This recycling offsets some localized impacts from TBP effluents, though solvent management remains critical to prevent additive phosphorus inputs.

Nuclear-Specific Safety Concerns

In nuclear fuel reprocessing, tributyl phosphate (TBP) diluted in hydrocarbons participates in processes like , where it extracts uranium and plutonium from nitric acid solutions derived from spent fuel. A primary concern is the formation of "red oil," a viscous, organo-nitrate mixture resulting from the thermal or hydrolytic degradation of TBP in contact with concentrated nitric acid, which can lead to exothermic runaway reactions and explosions when heated above 130–150 °C due to nitration of butyl fragments and subsequent autocatalytic decomposition. These reactions release gases like nitrogen oxides and hydrocarbons, potentially rupturing vessels or igniting if oxygen is present. Historical incidents include explosions at the in 1953, and at the in 1953 (semiworks evaporator) and 1975 (during uranyl nitrate conversion to UO₃), where inadvertent TBP carryover into heated nitric acid streams triggered deflagrations, though no off-site releases occurred due to containment. Radiolysis of TBP under high-radiation conditions in reprocessing streams generates acidic degradation products such as dibutyl phosphoric acid (HDBP) and monobutyl phosphoric acid (HMBP), which accumulate and form insoluble precipitates with metals like zirconium or technetium, fouling extraction columns, reducing phase separation efficiency, and necessitating frequent solvent cleanup. These products also increase organic acidity, promoting further corrosion or emulsion formation that complicates plutonium separation. Rates of degradation escalate with absorbed dose; for instance, at doses typical of initial PUREX cycles (∼10–20 kGy), TBP loss can reach 1–5% per cycle, impairing overall process yield. Reprocessing with TBP enables plutonium separation, posing proliferation risks as purified Pu-239 can be diverted for weapons, with pathways including undetected pilfering from hot cells or scaling up commercial facilities for clandestine production. However, these are mitigated by international safeguards, such as IAEA verification of material balances, real-time monitoring of fissile streams, and process designs incorporating co-extraction of uranium to complicate pure Pu isolation, alongside national controls under treaties like the NPT. Mitigations for TBP-specific hazards include selecting diluents like n-dodecane, which raise the red-oil ignition threshold by 10–20 °C compared to kerosene, strict temperature limits below 130 °C in evaporators and extractors with interlocks, and continuous monitoring of solvent composition via spectroscopy to detect degradation early. Facilities also employ segregated processing to prevent TBP ingress into acid concentrators and enhanced venting systems for runaway scenarios. Overall, operational experience from facilities like and demonstrates a safety record for reprocessing comparable to other chemical industries, with low collective dose rates (∼1–2 man-Sv per tonne processed) and rare severe incidents, as analyzed in OECD-NEA assessments of fuel cycle facilities.

Waste Management and Regulations

Degradation and Treatment Methods

Alkaline hydrolysis serves as a primary chemical method for degrading (TBP) in spent solvents, reacting TBP with sodium hydroxide to yield water-soluble sodium dibutyl phosphate, monobutyl phosphate, and butanol, facilitating phase separation and diluent recovery. Optimized conditions, including temperatures of 100–120°C and excess NaOH, achieve hydrolysis rates exceeding 99.5%, with reaction kinetics dominated by temperature as the key factor. This process is particularly applied to nuclear reprocessing wastes, where it destroys the organophosphorus structure without requiring extreme pressures, though it produces intermediate phosphates rather than full mineralization. Advanced oxidation techniques enable more complete mineralization of TBP to inorganic phosphate, carbon dioxide, and water. Wet air oxidation and Fenton processes oxidize TBP via hydroxyl radicals, attaining degradation efficiencies of 90–99% in lab settings, with total organic carbon (TOC) removal up to 95% under acidic conditions and hydrogen peroxide catalysis. Supercritical water oxidation (SCWO), operating at 400–600°C and 23–30 MPa, rapidly decomposes TBP with near-complete TOC conversion (>99%) in seconds, often enhanced by catalysts like metal oxides to mitigate from byproducts; however, material durability remains a challenge in handling radioactive variants. UV/H₂O₂ photolysis similarly promotes radical-mediated breakdown, confirmed effective for TBP removal in aqueous simulants. Biological degradation employs organophosphate-utilizing bacteria, such as Pseudomonas pseudoalcaligenes, which cleave TBP via enzymatic as a source, achieving 70–90% mineralization in batch cultures over 1–3 days at concentrations up to 5 mM. Immobilized cells in continuous reactors extend this to steady-state removal rates of 80–95%, though scalability is limited by at higher loads; alternative strains like Sphingobium sp. demonstrate 70% degradation in 200-L pilots over 15 days. In nuclear waste contexts, precedes these treatments to recover undegraded TBP (up to 90% purity), with residues directed to or SCWO for fixation into stable forms, necessitating shielded operations for radiolabeled intermediates. Lab-scale conversions routinely exceed 95%, but field applications contend with matrix interferences and byproduct volatility.

Regulatory Frameworks and Controls

In the United States, tributyl phosphate (TBP) is listed on the TSCA Chemical Substance Inventory and subject to testing requirements under Section 4 of the Toxic Substances Control Act, with the Environmental Protection Agency issuing rules in 1985 and updates mandating manufacturers and processors to generate data on its environmental and effects, including carcinogenicity and . TBP is also reportable under Section 8(d) of TSCA for and safety data submission, though it lacks a specific CERCLA reportable quantity designation, reflecting its classification as a non-acutely hazardous substance in certain contexts. Within the , TBP is registered under (EC) No 1907/2006 as a substance of potential concern for uses in flame retardants and extraction solvents, requiring safety data sheets and risk assessments for industrial handling, but it is not currently listed for authorization or restriction under Annex XIV or Annex XVII. Occupational exposure is controlled through derived no-effect levels (DNELs) informed by REACH dossiers, with recommended workplace airborne limits around 5 mg/m³ as a time-weighted average per ACGIH guidelines adopted in EU member states, emphasizing ventilation and to mitigate risks during manufacturing. For nuclear applications, the (IAEA) provides guidelines on TBP solvent management in fuel reprocessing, recommending purification of degraded TBP-kerosene mixtures to prevent explosive reactions with nitrates and acids, as outlined in technical reports on safe handling practices developed since the 1980s to standardize , monitoring, and segregation in licensed facilities. These protocols support compliance with national nuclear regulators, enabling scaled operations in reprocessing plants while minimizing release risks through like inert atmospheres and regular solvent analysis. Canada's Environmental Protection Act assessments, completed in 2011 and updated through screening reports, classify TBP as posing low ecological risk due to its failure to meet persistence or thresholds under the Persistence and Bioaccumulation Regulations, permitting continued use with restrictions on high-volume industrial discharges to surface waters. Similarly, risk assessments under REACH echo low potential at typical exposure levels, prioritizing containment over outright bans to balance industrial utility in solvent extraction against monitored releases. These frameworks have facilitated post-1980s enhancements in , such as improved and monitoring technologies, reducing operational incidents in nuclear relative to unregulated alternatives like once-through fuel cycles.

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